Clinical Trials

The Effect of Simvastatin Therapy on the Expression of Procoagulant and Inflammatory Markers in Heart Failure

Description

Status: Open to Enrollment

Start Date: Jan 01 2010

End Date: OPEN

This study targets patients without hyperlipidemia or traditional indications for statin therapy. Subjects will be randomized to simvastatin 40 mg or placebo. Response to simvastatin on inflammatory markers (tissue factor, IL-1, IL-6, IL-10, TNF-a) will be measured at baseline and at study termination (3 months).

Participant Eligibility

Inclusion Criteria:

  1. Age Range: 18-85
  2. LVEF class I to III, LVEF < 40%

Exclusion Criteria:

  1. Current Use of statin
  2. Heart failure due to active myocarditis, congenital heart disease, stenotic valvular disease
  3. LDL > 130 mg/dL in patients with evidence of ischemic disease (CAD, DVA, ACS, unstable angina, ischemic cardiomyopathy)
  4. Significant renal disease (SCr > 2.5 mg/dL) or hepatic disease (LFTs > 3 times upper limit of normal.)

Location(s) of the Clinical Trial

University of Utah Hospital Clinic #10

Principal Investigators

Mark Munger,

Contact Information

Name: Benjamin
Phone: 801-585-5317
Email: Benjamin.van tassel@hsc.utah.edu

Please Note:

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Although the studies described on this Web site may have potential benefits as described, the University of Utah and its physicians and affiliated hospitals cannot and do not guarantee or promise that you will receive any benefits from participating in a study.

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