Neuroimaging to Elucidate the Mechanism of Tic Resolution in Tourette Syndrome
Status: Open to Enrollment
Start Date: Jan 01 2010
End Date: OPEN
The purpose of the study is to help us learn more about Tourette’s syndrome. This is a condition that can affect up to four percent of children. It causes tics (involuntary movements, gestures, and sounds) that can be embarrassing and interfere with school and social life. About half of children with Tourette’s have dramatic improvement by the time they reach young adulthood. Those who do not may continue to have problems with work or even their everyday lives. Our study is designed to understand the brain changes that are involved in resolution of Tourette’s symptoms. This information may be useful to doctors to help predict (or, someday, influence) whether a child will outgrow his or her Tourette’s.
There have been some relatively new developments in MRI science that allow us to get much more detailed pictures and information- not just about the appearance of the brain, but its individual parts and their activity. We plan to use four of these techniques to study the brains of individuals with Tourette’s as well as people without psychiatric illness for comparison. The first technique, called volumetric MRI, tells us about the size of individual brain areas. The second, called diffusion tensor MRI, tells about the actual connections across the brain (known as axons) differ. The third, called functional magnetic resonance imaging (fMRI), allows scientists to discover which areas of the brain work together to perform brain functions. The fourth, called MRI spectroscopy, tells about concentration of individual brain chemicals (which may be important in controlling tics). In this study we will look at specific areas of the brain that are thought to be related to control of tics.
Inclusion Criteria: You are eligilble to participate if you:
1. Are a male aged 18-35 diagnosed with Tourette syndrome
2. Experience some social, academic or work-related problems due to tics.
3. Are not currently taking tic suppressing medications.
4. Have not had brain injury, brain surgery, or tumors involving the brain .
5. Do not have a diagnosis of epilepsy, autistic spectrum disorder or pervasive developmental disorder.
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