Stroke Hyperglycemia insulin Network Efforts (SHINE)
Status: Open to Enrollment
Start Date: Apr 09 2012
End Date: OPEN
The SHINE trial is a multi-site investigation funded by the Neurological Emergencies Treatment Trials (NETT).
The purpose of this study is to determine the efficacy and safety of tight glucose control to a target range of 80-130 mg/dl with IV insulin infusion in hyperglycemic acute stroke patients treated for up to 72 hours. Hyperglycemia is seen in approximately 40% of acute ischemic stroke patients and has been associated with worse clinical outcomes. Intravenous insulin therapy with tight glucose control has been found to improve clinical outcomes in some non-stroke acute illness trials. A clear determination of the risk and benefit of glucose control with IV insulin would have a dramatic impact on acute ischemic stroke patient therapy.
- Age 18 or older
- Clinical diagnosis of ischemic stroke
- History of type 2 diabetes mellitus and glucose >110 mg/dl or admission glucose >150 mg/dl
- Stroke symptom onset within 12 hours and hospital arrival within 3 hours
Name: Suyi Niu, Research Coordinator
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