Keywords:Infertility , Male Infertility , Obese Men and Infertility , Obesity
Specialty:Reproductive Endocrinology and Infertility
This project aim to study the role of aromatase inhibitors, in particular anastrozole, in the treatment of infertility in obese male. Obese male with sperm count between 5-15 million/ml will be randomized to receive anastrozole (1mg/day) or placebo. After 4 month of treatment, the final outcome will be improvement in sperm count.
1. Male partner of a couple presenting for infertility work up after one year of unprotected intercourse.
2. Moderate oligozoospermia (defined as sperm count ≤ 15 × 106/mL and ≥ than 5 × 106/mL) on at least two separate occasions spanning a minimum of two weeks.
3. Obese men BMI ≥ 30
4. FSH and LH levels < 10 mIU/mL
1. Severe Oligozoospermia: Sperm count < than 5 × 106/mL, including azoospermia.2. Age less than 18 or greater than 65 years3. Pyospermia or leukospermia: defined by white blood cells ≥1 million leukocytes per milliliter of semen. 4. Cryptorchidism5. Vasectomy reversal 6.Regular use of tobacco products7. BMI < 30 8. Use of anabolic steroids or testosterone replacement