Keywords: end stage renal disease , fistula maturation , hemodialysis access , hemodialysis , arteriovenous fistula , surgery
IRB Number: 00037892
Specialty: Vascular Surgery
This Hemodialysis Fistula Maturation (HFM) multi-center prospective cohort study will study approximately 600 patients undergoing an AVF creation surgery and follow their peri-operative and post-operative course until clinical maturation or abandonment. The cohort will include both current dialysis patients and patients with advanced chronic kidney disease (CKD) who are nearing end-stage renal disease (ESRD). The study will be conducted under a common protocol at the 6 HFMC clinical centers (Boston University, University of Cincinnati, University of Florida at Gainesville, University of Texas Southwestern, University of Utah, and University of Washington), with participation offered to all patients meeting broad enrollment criteria.
This protocol design uses an observational cohort study in order to determine the natural history of AVF maturation in a broadly representative population of HD patients.
Ancillary Vein Study:
The NIDDK-funded Hemodialysis Fistula Maturation (HFM) study collected 554 vein samples. About 1/3 of these vein samples (184 out of 554 samples) have incomplete circumferences. We propose to use the 370 full-circumference vein samples to develop an imputation model for estimating hyperplasia in partial-circumference vein samples and address the question of the usefulness of these partial samples. Our findings could potentially contribute to the fields regarding how to deal with incomplete cross-sections.