Status: Enrolling by invitation
Keywords: DT-MRI , Spinal Cord injury , High resolusion
IRB Number: 00022962
Specialty: Orthopaedic Surgery, Orthopaedic Surgery
Sub Specialties: Orthopaedic Spine Surgery,

Brief Summary

To determine the efficacy of high-resolution diffusion weighted pulse sequence with spatial resolution of 2.0 mm3 to confirm directionality and intactness of cervical spinal cord tracts in vivo in the setting of spinal cord injury and disease-free subjects.
To determine if DT Imaging will provide measures that correlate with
•clinical symptom severity
•clinical course

Principal Investigator: Brandon Lawrence
Department: Orthopedic Surgery
Co Investigator: Darrel Brodke
Co Investigator: Brandon Lawrence

Contact Information

Name:Ashley Woodbury
Phone: 801-339-2710
Email: Ashley.Neese@hsc.utah.edu

Inclusion Criteria

For inclusion to the Cervical Spinal Cord (CSM):
-Clinical and radiographic evidence of cervical spondylotic myelopathy
-18 to 80 years of age
-Safe and stable clinical scenario to undergo imaging
-Awake, alert patient able to cooperate with physical examination
-Give written informed consent prior to any testing under this protocol

For includion to the Control Group, subjects must have:
-No diagnosis of cervical spinal cord disease
-30 to 80 years of age
-Ability of volunteers to tolerate 1 hr examination

For inclusion criteria to the Degenerative Disease Group, subject must have:
-Have signs or symptoms consistent with spinal cord injury
-Be diagnosed with cervical spondylosis (degenerative disease).

For inclusion to the Traumatic Group, subject must have:
-A spinal cord injury associated with a traumatic event

Exclusion Criteria

For exclusion to the Cervical Spinal Cord (CSM):
-Unsafe or unstable clinical scenario
-Prior cervical spine surgery
-History of neurological disease (stroke, multiple sclerosis, peripheral neuropathy, or other neurodegenerative conditions)
-Inability to comply with physical examination
-Contraindications to MRI imaging (metal debris, cardiac pacemaker, etc.)
-Pregnant women

For exclusion to the other groups:
-Inability to comply with physical examination
-Contraindications to MRI imaging (metal debris, cardiac pacemaker, etc.)
-Pregnant women