Coatings for Migraine


Status: Completed
Keywords: Migraine , Eye glass coating
IRB Number: 00047263
Specialty: Ophthalmology, Neurology
Sub Specialties: Neuro-Ophthalmology, Headache

Brief Summary

Nearly all migraine sufferers report sensitivity to light during a headache and a significant proportion of sufferers report light sensitivity between attacks. Light is also a common trigger for migraine headaches. Preliminary evidence indicates that migraine patients may be more sensitive to a particular portion of the visible spectrum. We hypothesize that if we could selectively block this portion of the visible spectrum, we could reduce the frequency and severity of headaches in migraine patients. The objective of this proposal is to develop coatings that can be applied to spectacle lenses, contact lenses, and light sources that will block the target wavelengths. The filters will then be tested in a cohort of adult patients with migraines. If successful, these filters could be a novel, non-invasive adjuvant in the treatment of migraines.

The long-term goal of the project is to reduce the severity and frequency of migraines in patients who are sensitive to light.  The goal of this protocol is to test an optical filter that blocks the wavelengths of light known to trigger migraines.

The PI is developing thin film coatings that will be applied to spectacle lenses. In this protocol, the investigators will determine the efficacy these prototype filters in a cohort of migraine patients.

Principal Investigator: Bradley Katz
Department: Ophthalmology-Services
Co Investigator:

Contact Information

Name:Barbara Hart
Phone: 801-581-6459

Inclusion Criteria

All subjects must meet the International Headache Society (IHS) criteria for migraine and chronic daily headache (15 or more headache days per month).

All subjects will be 18 years or older. The frequency of migraine headache in females is roughly twice that in males, and it is expected that the study population will reflect this gender disparity.

Exclusion Criteria

Subjects with other light sensitive conditions, such as iritis and blepharospasm, will be excluded. We will exclude patients with degenerative diseases of the retina or optic nerve, patients taking medications known to affect retinal function, and diabetic patients. We will exclude any subjects already wearing prescripton tinted lenses.  Subjects with best-corrected visual acuity less than 20/40 will be excluded.