Nearly all migraine sufferers report sensitivity to light during a headache and a significant proportion of sufferers report light sensitivity between attacks. Light is also a common trigger for migraine headaches. Preliminary evidence indicates that migraine patients may be more sensitive to a particular portion of the visible spectrum. We hypothesize that if we could selectively block this portion of the visible spectrum, we could reduce the frequency and severity of headaches in migraine patients. The objective of this proposal is to develop coatings that can be applied to spectacle lenses, contact lenses, and light sources that will block the target wavelengths. The filters will then be tested in a cohort of adult patients with migraines. If successful, these filters could be a novel, non-invasive adjuvant in the treatment of migraines.
The long-term goal of the project is to reduce the severity and frequency of migraines in patients who are sensitive to light. The goal of this protocol is to test an optical filter that blocks the wavelengths of light known to trigger migraines.
The PI is developing thin film coatings that will be applied to spectacle lenses. In this protocol, the investigators will determine the efficacy these prototype filters in a cohort of migraine patients.
Principle Investigator: Bradley Katz
Principle Department: Ophthalmology-Services