Keywords: Claudication , Peripheral Artery Disease , Magnetic Resonance Imaging , Healthy Volunteer , Gadolinium Contrast , Muscle Imaging , Lower Extremity Pain
IRB Number: 00050494
Specialty: Vascular Surgery, Radiology
Sub Specialties: Magnetic Resonance Imaging – MRI
To systematically develop, test, and refine peripheral vascular ECG-gated fast spin echo (FSE) MRI for the accurate diagnosis of PAD without Gd contrast.
To test prospectively the accuracy of FSE in 200 PAD patients, compared with bolus-chase and time-resolved Gd-MRA and, in a subset, intraoperative x-ray angiography as reference techniques. Additionally, as a substudy of this project, we will compare our FSE approach with alternative non-contrast-enhanced MRI methods such as time-of-flight and steady-state gradient echo imaging.
The overarching goals of our research are to develop and validate a peripheral MRA technique that accurately depicts anatomy and disease without exposing patients to exogenous contrast material and its associated risks.
To develop, test, and refine advanced muscle MR imaging techniques, including BOLD, ASL and both myoglobin and phosphorus spectroscopy.
Hypothesis: Using advanced MR techniques, we can examine the extent of oxygenation, energetics, and perfusion abnormality present in lower extremity musculature in patients with PAD.
To develop techniques to utilize these non-gadolinium techniques to evaluate extremity vascularity in patients with frostbite before and after treatment with tPA or other medications.
Principle Investigator: Vivian Lee
Principle Department: University of Utah
Phone: (801) 585-6142