Hip Dysplasia Study


Status: Enrolling by invitation
Keywords: Hip Dysplasia , Hip preservation , Labral Tear
IRB Number: 00010983
Specialty: Orthopaedic Surgery, Orthopaedic Surgery
Sub Specialties: Periacetabular Osteotomy, Hip Preservation

Brief Summary

This study will examine the biomechanics of the hip in normal and dysplastic patients, specifically focusing on patients with "traditional" dysplasia versus those with a dysplastic "retroverted" acetabulum. Patient-specific computer models will be used to predict contact areas, maximum cartilage stresses and maximum bone stresses and their locations for the three patient groups analyzed (normal, traditional dysplastic, retroverted dysplastic). These models will also be used to study the effects of simulated cartilage and labral damage on joint mechanics. CT athrography will be used to image each subject (contrast enhanced CT). If the subject agrees to the secondary study then motion analysis will be used to record the movements and kinematics during walking, stair climbing and descending stairs. These movements will be use to provide motion and loading data to the computational models on a patient-specific basis. Finally, an MRI scan, using a test protocol, will be obtained of all persons who consent to such. Models developed from the MR images will be compared to models developed from the CT images to determine if MRI could possibly be used in the future to replace CT for the purpose of generating finite element models of the hip joint. MRI is of interest to our group as it is non-invasive with regards to radiation exposure. Also, it is possible that the MRI protocol we seek to develop and test herein could replace existing clinical MR protocols for all patients with suspected hip dysplasia. Existing MR protocols are low resolution, do not afford good visualization of the two cartilage layers, and are not acquired using a 3D sequence.

Principal Investigator: Christopher Peters
Department: Orthopedic Surgery
Co Investigator: Chris Pelt

Contact Information

Name:Michael Anderson
Phone: 801-213-3442
Email: mike.anderson@hsc.utah.edu

Inclusion Criteria

It is expected that 119 subjects will be enrolled in this study during a period of up to five years. The distribution of subjects is as follows: 42 “normal” subjects, 49 “traditional dysplasia” subjects, and 28 “retroversion” subjects. We will recruit as many subjects as possible for the motion analysis study and MRI scan - with a total of up to 119 subjects: 42 “normal” subjects, 49 “traditional dysplasia” subjects, and 28 “retroversion” subjects.

Exclusion Criteria

Persons with a history of allergies to lidocaine or seafood. Children under the age of 18, persons incarcerated, on trial, or parole. Women who are pregnant. Subjects who have had prior hip surgeries that include peri-acetabular osteotomy or femoral debridement surgery.  Subjects with metal in their body that prevent them from obtaining an MRI scan will be excluded from the MRI portion of this study (they may still participate in the other aspects of the study).