This (non-hypothesis driven) proposal is to develop a blood sample and tissue bank. The bank will be used to test numerous hypotheses with primarily cohort-control studies. Examples of such studies would be to determine whether there is a genetic predisposition towards endometriosis or if the endometrial lining of the uterus in women with endometriosis expresses a unique expression profile in women who have endometriosis. Development of the bank will greatly facilitate the rapid completion of such studies as hypotheses are developed. In addition, the creation of a “bank” including blood for DNA; as well as residual urine samples, endometrial tissue from the uterus, ectopic endometrial implants found in the peritoneum, peritoneal fluid, and peritoneal fat will be a resource for multiple investigators. The clinical data collected will greatly facilitate the coordination of similar studies that involve the same cohort of patients. It is much simpler and more efficient for patients and investigators to work with one set of data, samples and consents. This type of arrangement would not work for all types of studies, but seems appropriate when 1) similar data and samples are required from a unique cohort, 2) participation involves only blood and data collection regarding medical issues (minimal risk) 3) the collection includes the storing of residual samples from the ENDO or other studies that would otherwise be discarded. The samples will be stored indefinitely as stated in the consent form.
Banking tissue/blood will allow us to more rapidly test new hypotheses as information becomes available. It will also facilitate the development of tests that may help in the diagnosis and treatment of conditions such as endometriosis and other pelvic pain conditions.
As research questions are identified, separate IRB applications will be submitted to utilize samples from the bank.
Principle Investigator: Matthew Peterson
Principle Department: Reproductive Endrocrinology