Sodium Breast MRI

Overview

Status: Recruiting
Keywords: Magnetic Resonance Imaging , Sodium Breast Imaging , Breast Cancer Screening
IRB Number: 00056812
Specialty: Radiology, Radiology
Sub Specialties: Women's Imaging, Magnetic Resonance Imaging – MRI

Brief Summary

 Objectives

 1.Demonstrate the feasibility of breast sodium MRI as a component of breast MRI examination.

2.Test the hypothesis that tissue sodium quantification with MRI can be used to classify breast lesions as benign or malignant

Principal Investigator: Glen Morrell
Department: Radiology Clinical
Co Investigator:

Contact Information

Name:Kristi Carlston
Phone: (801) 587-8190
Email: mjb27@utah.edu

Inclusion Criteria

Patients will be enrolled who are scheduled to undergo breast biopsy based on abnormal x-ray mammogram or ultrasound.  Recruitment will be performed by Dr. Matthew Stein and Dr. Matthew Morgan, breast imagers in the Radiology Department at the University of Utah.  Subjects will be recruited in the Breast Cancer Center located in the Huntsman Cancer Hospital  at the University of Utah at the time of x-ray mammogram or breast ultrasound.  In past studies (e.g. (12)) this patient population has proven to be extremely altruistic in their willingness to participate in trials that they perceive may benefit future breast cancer patients.   In the one-year period from 7/1/2009 to 6/30/2010, 490 stereotactic and ultrasound guided breast biopsies were performed in our department. We believe recruitment of 40 patients in the study period is an acheivable goal.  To facilitate patient recruitment, MRI scan time slots may be reserved immediately before biopsy appointments so that patients may easily participate in the research MRI immediately before their breast biopsy procedure.

Control Group Cohort:

Healthy volunteers 18 years and older, able to give consent.

Exclusion Criteria

 Exclusion criteria include age under 18 years, history of diabetes or renal insufficiency with estimated glomerular filtration rate (GFR) less than 60 mL/min/1.73m2, and routine exclusion criteria for MRI outlined on the MRI safety screening form (i.e. metal in the orbits, cardiac pacemaker, cochlear implant, stents or other prosthetic devices which have not been tested for MRI compatibility).

Exclusion from receiving contrast will not be an exclusion from study participation. Participants can decline contrast injection and this will not be considered a protocol deviation.