Exercise Intervention to Improve Glucose Tolerance
|Principal Investigator: Jim Martin|
|Keywords: insulin , exercise , metabolilc syndrom||Department: Exercise And Sport Science|
|IRB Number: 00056766||Co Investigator: KyleWehmanen|
|Specialty: Endocrinology and Metabolism, Endocrinology and Metabolism, Endocrinology and Metabolism|
|Sub Specialties: Prediabetes, Diabetes, Type 2 Diabetes|
The objective of this study is to determine if single leg cycling training improves glucose tolerance and other health related variables to a greater extent than double leg cycling training in individuals with metabolic syndrome and insulin resistance.
A total of 24 participants, 18-60 years of age, who exhibit metabolic syndrome, will be recruited to participate in this study. Our recruitment strategy will involve inviting individuals with easily determined risk factors including waist circumferences of greater than 40 inches and 35 inches for males and females and BMI values greater than 28, to take part in screening. Participants will be recruited via flyers placed throughout the University of Utah Hospital and main campus. The first level of screening will include confirmation of waist circumference and BMI, blood pressure measurement, and a blood test to determine levels of fasting glucose and lipids low density lipoprotein (LDL) cholesterol and, high density lipoprotein (HDL) cholesterol. This blood test requires only a simple finger stick and will be performed by personnel at the PEAK Academy or the Utah Center for Clinical and Translational Science. The criteria for metabolic syndrome will include meeting the standard for waist circumference and at least two of the following standards: fasting glucose >100 mg/dL, lipids > 150 mg/dL, HDL cholesterol values of < 40 mg/dL in males or < 50 mg/dL in females, and blood pressure values of > 130 or diastolic BP >85 mm Hg. Those confirmed with metabolic syndrome will be further screened for insulin resistance with a test of fasting insulin and glucose. This will require a blood draw from the antecubital vein and will be performed by personnel at the Center for Clinical and Translational Science at the University of Utah Hospital. From those insulin and glucose data the Clamp Like Index of Insulin Resistance (CLIX-IR) will be performed and the criteria for insulin resistance will be CLIX-IR values of <5.3. Individuals confirmed with metabolic syndrome and insulin resistance will be invited to participate in the training intervention study. Those whose tests indicate frank type II diabetes (glucose ≥ 200 mg/dL) will be excluded from the study and will be referred for proper diabetes care. Volunteers will be excluded if they have symptoms of clinically relevant conditions which would preclude intense exercise or are on any clinically relevant medication within four weeks of the start of the study.
Individuals who do not meet the inclusion criteria will be excluded.
Individuals who are pregnant.
Individuals who, during the screening process are discovered to have frank Type II diabetes.
Individuals with a history of history of coronary artery disease (angina, heart attack, stent, bypass surgery), congestive heart failure, valvular heart disease, or significant arrhythmia (e.g. supraventricular tachycardia, atrial fibrillation, ventricular tachycardia, ventricular fibrillation).