Our study will seek to determine if there is correlation between the progression of glaucoma in specific glaucoma subset groups and vascular parameters in the eye, more specifically the choroid. To achieve this we will look at measurements relating to vascular parameters in the eye in three different subsets of subjects, primarily: normal tension glaucoma (NTG), primary open angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXF) subjects and healthy individuals. We will primarily examine intraocular pressure (IOP), choroidal thickness and ocular pulse amplitude (OPA) among the patient groups, along with blood pressure, ocular perfusion pressure (OPP), heart rate, contrast sensitivity and multifocal electroretinograms. Correlations will be assessed between variables as well as between the subset of glaucoma patient groups to assess trends. Our hypothesis is that the glaucomatous patients will have alterations in these vascular parameters and functional endpoints that either correlate with the type of glaucoma and or the severity of the optic neuropathy.
We will analyze this link by measuring choroidal thickness, calculated OPP and OPA, using some of the most advanced techniques and equipment available in the field of ophthalmology research. Correlations will be assessed between variables as well as between the subset of glaucoma patient groups to assess trends. The aim of this study is to help to further the understanding of ocular blood flow and vascular parameters in glaucoma.
Principal Investigator: Barbara Wirostko