Study Design: This is a prospective observational study of 53 children recruited from MWPNC centers with incident nephrotic syndrome designed to assess 25-vitamin D status.
SYNOPSIS: The primary goal of this study is to define the prevalence of 25-vitamin D deficiency at presentation and the association of 25-vitamin D relative to response to steroid therapy response patterns in children with incident idiopathic nephrotic syndrome.
Specific Aim 1: Evaluate the prevalence of 25-vitamin D deficiency in children at the time of diagnosis with idiopathic nephrotic syndrome
Hypothesis: At presentation patients will have a greater incidence of 25-vitamin D deficiency than the general population.
Specific Aim 2: Evaluate the association between the patterns of nephrotic syndrome treatment response and 25-vitamin D levels in children with incident nephrotic syndrome.
Hypothesis: 25-vitamin D levels will be lowest in treatment resistant patients compared with treatment responsive patients.