Urine Acid Excretion in Chronic Kidney Disease (CKD)
|Principal Investigator: KalaniRaphael|
|Keywords: chronic kidney disease , renal disease , kidney , observational , acid-base balance||Department: Nephrology|
|IRB Number: 00060458||Co Investigator:|
|Specialty: Nephrology and Hypertension|
Hypothesis: Urinary NH4+ excretion rate, as a measure of renal ammoniagenesis, is a risk factor for CKD progression and death.
Specific Aim: To determine if urinary NH4+ excretion rate is a risk factor for CKD progression in patients at the University of Utah with stages 3 and 4 CKD.
1. Age older than 18 years
2. Stage 3 or 4 CKD (eGFR 15 - 59 ml/min/1.73m2 using the MDRD equation)
*There is no difference in the inclusion criteria for participants recruited from the VA vs the University of Utah.
1. Presence of a urinary conduit, such as a neobladder or urostomy.
2. History of chronic urinary tract infections (for example > 3 per year, or requires chronic suppressive treatment).
*There is no difference in the exclusion criteria for participants recruited from the VA vs the University of Utah.