NMTRC 008

Overview

Status: Not yet recruiting
Keywords: Molecularly guided therapy , Refractory Childhood cancers , Neuroblastoma , Brain tumor , Rare tumor
IRB Number: 00061331
Specialty: Pediatric Hematology and Oncology
Sub Specialties:

Brief Summary

Primary Objectives: Determine feasibility of using tumor samples to assess genomic mRNA expression arrays and DNA mutation panels using predictive modeling to make real-time treatment decisions for children with relapsed/refractory cancers.

Secondary Objectives:

♦ To continue to determine the safety of allowing a molecular tumor board to determine individualized treatment plans

♦ To determine the activity of treatments chosen based on:

• Overall response rate (ORR)

• Progression free survival (PFS)

♦ To explore the relationship between tumor phenotype and response by permitting use of tumor tissue in a correlative biologic study

♦ To compare PFS interval to PFS intervals of previous chemotherapy regimens since relapse for each subject.

Detailed Description

This is an open label, multicenter prospective study to evaluate the ability of using genome-wide expression profiles and mutation panels of a child’s tumor to predict individualized therapies for patients.

Principal Investigator: Mark Fluchel
Department: Pediatric Administration
Co Investigator: Phillip Barnette

Contact Information

Name:Jason Clawson
Phone: 801-213-3765
Email: jason.clawson@hsc.utah.edu

Inclusion Criteria

 

1. Subjects must have histologically proven neuroblastoma, brain tumor, or rare tumor and confirmation of refractory or recurrent disease with histologic confirmation at diagnosis or at the time of recurrence/progression

2. Subjects must be age >12 months at enrollment

3. Subjects must be age ≤ 21 years at initial diagnosis

4. Subjects must have measurable disease as demonstrated by residual abnormal tissue at a primary or metastatic site measuring more than 1 cm in any dimension by standardized imaging (CT or MRI); tumor must be accessible for biopsy. Subjects with bone marrow only disease expected to be >75% tumor are eligible to enroll.

5. Current disease state must be one for which there is currently no known curative therapy

6. Lansky or Karnofsky Score must be more than 50

7. Subjects without bone marrow metastases must have an ANC > 750/μl.

8. Adequate liver function must be demonstrated, defined as:

a. Total bilirubin ≤ 1.5 x upper limit of normal (ULN) for age AND

b. ALT (SGPT) < 10 x upper limit of normal (ULN) for age

9. A negative serum pregnancy test is required for female participants of child bearing potential (≥13 years of age or after onset of menses)

10. Both male and female post-pubertal study subjects need to agree to use one of the more effective birth control methods during treatment and for six months after treatment is stopped. These methods include total abstinence (no sex), oral contraceptives ("the pill"), an intrauterine device (IUD), levonorgestrol implants (Norplant), or medroxyprogesterone acetate injections (Depo-provera shots). If one of these cannot be used, contraceptive foam with a condom is recommended.

11. Informed Consent: All subjects and/or legal guardians must sign informed written consent. Assent, when appropriate, will be obtained according to institutional guidelines

 

Exclusion Criteria

 

1. Subjects who have received any cytotoxic chemotherapy within the last 7 days prior to enrollment and 14 days prior to study treatment start date.

2. Subjects who have received any radiotherapy to the primary sample site within the last 14 days (radiation may be included in treatment decision after biopsy).

3. Subjects receiving anti-tumor therapy for their disease or any investigational drug concurrently.

 

4. Subjects with serious infection or a life-threatening illness (unrelated to tumor) that is > Grade 2 (NCI CTCAE V4.0), or active, serious infections requiring parenteral antibiotic therapy.

5. Subjects with any other medical condition, including malabsorption syndromes, mental illness or substance abuse, deemed by the Investigator to be likely to interfere with the interpretation of the results or which would interfere with a subject’s ability to sign or the legal guardian’s ability to sign the informed consent, and subject’s ability to cooperate and participate in the study