Effect of Resistance Training on Muscle Quality


Status: Not yet recruiting
Keywords: Bariatric Surgery , Muscle quality
IRB Number: 00060448
Specialty: Surgery, General
Sub Specialties: Bariatric Surgery

Brief Summary

The purpose of this study is to determine the effects of a periodized resistance training program on  muscle cross sectional area, muscle quality, and its impact on daily activity in patients having undergone gastric by-pass surgery.

We hypothesize that resistance training will significantly improve muscle quality and attenuate loss of muscle. Also, resistance training will significantly increase strength. The aims of this study are to look at the effects a 12-week periodized RT program on: 1) muscle cross sectional area 2) absolute strength 3)  muscle quality 4)  spontaneous daily activity. A secondary aim of this study is to determine if RT impacts muscle density in this population.

Principal Investigator: Paul Daniels
Department: Exercise And Sport Science
Co Investigator: Kristen Ouellette

Contact Information

Name:Paul Daniels
Phone: 530-863-3032
Email: p.daniels@utah.edu

Inclusion Criteria

Severely obese adult females of all races that have a BMI >or= 35, but <60 kg/m2 who are scheduled for bariatric surgery at one of the surgical centers in the Salt Lake Valley. Total enrollment will be 28 subjects to allow for 4 participants to dropout.   

Exclusion Criteria

We will exclude from all groups during recruitment participants with the following conditions for potential confounding effects on the measurement of variables of interest:

1-Active cancer

2-History of myocardial infarction, coronary bypass surgery, angioplasty or stroke

3-Type 1 and 2 diabetes

4-Claustrophobia, cardiac pacemakers, or other established contraindications to MRI imaging

5-Post-surgical anemia

6-Current smokers or those having smoked in the past 6 months

7- Musculoskeltal defects which limit activity

Patients with a BMI<35 kg/m2 or >60 kg/m2 will be eliminated as extreme outliers. Patients that develop post-surgical complications which prevent them from further participation in the study will be replaced by a new participant. We estimate a maximum of 4 subjects enrolled will need to be replaced.