Functional Connectivity on fMRI in Traumatic Cervical Spine Cord Injury

Overview

Status: Recruiting
Keywords: Spinal Cord Injury (SCI) , Magnetic Resonance Imaging , Diffusion Tensor Imaging
IRB Number: 00063552
Specialty: Radiology, Neurosurgery, Radiology, Radiology, Radiology
Sub Specialties: Head and Neck Imaging, Neuroradiology, Magnetic Resonance Imaging – MRI

Brief Summary

The aim of this project will be to determine the presence of reorganization in cortical motor neural networks following spinal cord injury (SCI) compared to healthy volunteers utilizing resting-state fMRI. Clinical correlations with ASIA impairment scale will also be performed. In addition, using diffusion tensor imaging (DTI) we hope to show that SCI will be associated with altered diffusion properties in the primary motor cortex, greatest in the region of primary motor cortex that innervates the paralyzed part of the body as well as in the descending corticospinal tract fibers, indicative of significant neural loss. Ultimately, these findings might be used to predict outcome in patients with traumatic spinal cord injury, identify neural substrates of complications such as phantom limb syndrome, and help to design more effective therapeutic strategies.

 

Principal Investigator: Lubdha Shah
Department: Radiology Clinical
Co Investigator: Jeffrey Anderson
Co Investigator: Erica Bisson
Co Investigator: Meic Schmidt

Contact Information

Name:Kristi Carlston
Phone: (801) 587-8190
Email: mjb27@utah.edu

Inclusion Criteria

The main inclusion criterion is patients referred to the University of Utah for acute cervical spinal cord injury. 

Exclusion Criteria

Exclusion criteria include patient’s chronological age less than 18 years or older than 41 years of age, a past medical history significant for (1) neurologic disease including cervical spondylotic myelopathy, or systemic disease affecting the central or peripheral nervous system or (2) traumatic brain injury. Prisoners and pregnant women will be excluded.