Approximately 3.2 million persons in the U.S are estimated to have chronic Hepatitis C Virus (HCV) infection.1 Chronic HCV infection may result in chronic liver disease, cirrhosis of the liver or, more rarely, death due to the consequences of chronic liver infection.
It is known that almost all cases of pediatric HCV are the result of transmission of the HCV infection from mother to baby. Studies suggest that the prevalence of HCV infection in pregnancy ranges from 0.6% to 2.4%. Several European studies suggest that the rate of mother to child transmission of HCV is 5% to 10%. However, it is unclear what percentage of these children will spontaneously clear the infection and what percentage will have persistent HCV infection. While maternal co-infection of HIV has emerged as a significant risk factor, study results regarding other possible risk factors associated with mother to child transmission have been mixed.
The purpose of this study is to understand risk factors associated with mother to child transmission of HCV.
Principle Investigator: Michael Varner
Principle Department: Maternal-Fetal Medicine