Sleep and Pain Project
|Principal Investigator: AkikoOkifuji|
|Keywords: Fibromyalgia , Fibromyalgia Syndrome , Myofacial pain syndrome , Fibromyositis , Fibrositis||Department: Anesthesiology|
|IRB Number: 00066529||Co Investigator: GaryDonaldson|
|Sub Specialties: Chronic Pain|
The primary goal of this project is to collect pilot data evaluating the relationship between sleep quantity/quality (measured both subjectively and objectively) and pain (both clinical and experimentally induced) in women with fibromyalgia syndrome (FMS) relative to healthy women. We hypothesize that poor sleep, defined either objectively or subjectively will be related to greater pain sensitivity and pain report in both FMS and healthy women, although in general, FMS patients hould exhibit greater pain sensitivity than healthy controls. We will also explore how telomere lenth, an indication of cellular aging (which is known to be shorter in FMS and sleep deprived people), is linked to the pain-sleep relationship.
We plan to recruit 40 women with FMS (Age 21-65) and 40 age matched healthy women from the community advertisement. All subjects will be sedentary (in order to match the fitness level) defined as not regularly engaging in exercise more than
30 120 minutes a week. For FMS patients, we will confirm the diagnosis based upon the 1990 American College of Rheumatology (ACR) classification criteria and 2010 ACR criteria.
The exclusion criteria for FMS patients include: Co-occurring progressive disease, pregnancy, having known cardiovascular, neurologic, or endocrine diseases, having known serious psychopathology (Clinician diagnoses of psychosis, organic mental disorder, or dissociative disorder, self-reported active suicidal intent, self-reported history of inpatient admission to psychiatric ward in the past year, evidence or self-report of self-injurious behaviors in the past year, reported current or recent history (2years) of non-IV substance abuse, any history of recreational IV drug use), having autoimmune disorder (e.g., rheumatoid arthritis) (self-report, physician diagnosed),having other pain disorders, having pain associated with terminal illness, acute pain, pain associated with specific organ damage (eg, stomach ulcer), requiring an interpreter to communicate. For healthy people, those exclusion criteria also apply and they should not have any chronic pain condition. For both groups, no person who takes hypnotics, OTC sleeping aids, opioids, and regular NSAIDs will be recruited.