aPL in Women with Severe Preeclampsia and Placental Insufficiency


Status: Recruiting
Keywords: Preeclampsia , anti-phospholipid antibodies , placental insufficiency , pre-term delivery
IRB Number: 00068989
Specialty: Women and Children's Health
Sub Specialties:

Brief Summary

The objective of this study is to determine the relationship between aPL (persistently positive) and severe preeclampsia or placental insufficiency using adequate case numbers and appropriately matched controls. To insure adequate numbers of cases can be obtained, other interested centers around the world will be invited to use an identical protocol and data collection system and their regional APS ACTION core laboratories. 

Principal Investigator: David Branch
Department: Maternal-Fetal Medicine
Co Investigator:

Contact Information

Name:Samantha Nielsen
Phone: 801-585-7617
Email: sam.nielsen@hsc.utah.edu

Inclusion Criteria

All patients who seek or receive medical care at the University of Utah Health Sciences Center for severe preeclampsia or placental insufficiency with a singleton pregnancy will be invited to participate.

Control women without severe preeclampsia or placental insufficiency will be matched to cases by age (±5 years), parity and gestational age of delivery (±10 gestational days). 



Exclusion Criteria

No subjects will be excluded on the basis of medical disease, though data regarding potentially confounding diagnoses, e.g., chronic hypertension, will be collected.  Women without severe preeclampsia or placental insufficiency will be used as controls. 

Women with intellectual disability and incarcerated individuals will not be included in this study.

Multiple gestation pregnancies. 

Fetal anomalies known to be associated with abnormal growth and fetal heart tones.  ie. gastroschisis, HLHS, etc.