aPL in Women with Severe Preeclampsia and Placental Insufficiency
|Principal Investigator: DavidBranch|
|Keywords: Preeclampsia , anti-phospholipid antibodies , placental insufficiency , pre-term delivery||Department: Maternal-Fetal Medicine|
|IRB Number: 00068989||Co Investigator:|
|Specialty: Women and Children's Health|
The objective of this study is to determine the relationship between aPL (persistently positive) and severe preeclampsia or placental insufficiency using adequate case numbers and appropriately matched controls. To insure adequate numbers of cases can be obtained, other interested centers around the world will be invited to use an identical protocol and data collection system and their regional APS ACTION core laboratories.
All patients who seek or receive medical care at the University of Utah Health Sciences Center for severe preeclampsia or placental insufficiency with a singleton pregnancy will be invited to participate.
Control women without severe preeclampsia or placental insufficiency will be matched to cases by age (±5 years), parity and gestational age of delivery (±10 gestational days).
No subjects will be excluded on the basis of medical disease, though data regarding potentially confounding diagnoses, e.g., chronic hypertension, will be collected. Women without severe preeclampsia or placental insufficiency will be used as controls.
Women with intellectual disability and incarcerated individuals will not be included in this study.
Multiple gestation pregnancies.
Fetal anomalies known to be associated with abnormal growth and fetal heart tones. ie. gastroschisis, HLHS, etc.