Rapid Cine MRI

Overview

Status: Recruiting
Keywords: Atrial fibrillation , A Fib , Heart Failure , Echo , Echocardiography , MRI
IRB Number: 00070041
Specialty: Cardiology, Radiology, Radiology
Sub Specialties: Cardiac Imaging, Magnetic Resonance Imaging – MRI

Brief Summary

The specific objectives of our proposal are to develop highly-accelerated ungated real-time cine MRI with CS, evaluate this real-time cine MRI approach for diagnostic confidence, intra-scan repeatability, and inter-reader variability, and develop real-time CS reconstruction methods for clinical translation.

Currently, transthoracic 2D echocardiography is the most widely used diagnostic test for real-time imaging of LV function, but it often yields poor diagnostic confidence and high reader variability in AF. In direct response to this unsolved clinical problem, our proposal seeks to develop and evaluate a rapid real-time cine MRI method that yields high diagnostic confidence, scan repeatability, and inter-reader agreement for reliable risk stratification of ICD candidates in AF.

Principal Investigator: Daniel Kim
Department: Radiology Research
Co Investigator: Chris McGann
Co Investigator: Brent Wilson

Contact Information

Name:Lisa Dubler
Phone: (801) 587-8190
Email: Lisa.Dubler@hsc.utah.edu

Inclusion Criteria

MRI Only Cohort:

Subjects 18 years of age or older with AF (Atrial fibrillation) that have been scheduled for a clinical MRI will be recruited from the EP clinic at the University of Utah. Subjects will be selected on the basis of their willingness and ability to participate, on their comprehension of the informed consent document, on their likelihood of completing the study. Signed informed consent will be required for all patients participating in this investigation.

Echocardiography with MRI Cohort:

Subjects with AF and HF (heart failure) that are scheduled for clinical echocardiography will be recruited from the cardiology inpatient clinic at the University of Utah. Following an echo exam, subjects will be selected on the basis of their willingness and ability to participate, on their comprehension of the informed consent document, on their likelihood of completing the study. Signed informed consent will be required for all patients participating in this clinical investigation.

Exclusion Criteria

MRI Only Cohort:

Exclusion criteria:

  1. Electrical implants such as cardiac pacemakers or perfusion pumps
  2. Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants
  3. Pre-existing medical conditions that might prevent the patient from undergoing MR imaging, including a likelihood of developing seizures or claustrophobic reactions, and any greater than normal potential for cardiac arrest.

Echocardiography with MRI Cohort:

 Exclusion criteria:

  1. Electrical implants such as cardiac pacemakers or perfusion pumps
  2. Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants
  3. Pre-existing medical conditions that might prevent the patient from undergoing MR imaging, including a likelihood of developing seizures or claustrophobic reactions, and any greater than normal potential for cardiac arrest.