Pamela B. Cassidy, Ph.D.
Adjunct Research Assistant Professor, Department of Dermatology
Research Assistant Professor, Department of Medicinal Chemistry, Huntsman Cancer Institute
- B.A., 1982, University of California, Berkeley (Chemistry)
- Ph.D., 1996, University of Utah (Chemistry)
- Postdoctoral Fellow, 1999-2002, Huntsman Cancer Institute
- Postdoctoral Fellow, 1995-1998, Department of Medicinal Chemistry, University of Utah
Clinical and Research Interests
I am interested in understanding the roles of oxidative stress in cancer etiology and prevention. My research is focused on the study of antioxidant selenium-containing proteins. Our intent is to use information about the function of these proteins to guide our efforts to treat and prevent melanoma. I also work with physicians in our department as we test new drugs for prevention of melanoma. This effort includes understanding the genetic basis of melanoma susceptibility with the goal of tailoring prevention strategies to fit individual risk.
Selected Publications
- Selenazolidines as Novel Organoselenium Delivery Agents. Xie, Y., Short, M.D., Cassidy, P.B., Roberts, J.C. Bioorgan. Med. Chem. Lett., 2001, 11:2911.
- A New and Versatile Method for Determination of Thiolamines of Biological Importance. Dominick, P.K., Cassidy, P.B., Roberts, J.C.J. Chromatography B 2001, 761:1.
- Thiazolidine Prodrugs as protective Agents against γ-Radiation-Induced Toxicity and Mutagenesis in V79 cells. Wilmore, B.H., Cassidy, P.B., Warters, R. L., Roberts, J.C. J. Med. Chem. 2001, 44:2661.
- Cyclooxygenase-2 Induction by Paclitaxel, Docetaxel and Taxane Analogs in Human Monocytes and Murine Macrophages: Structure-Activity Relationships and Their Implications. Cassidy, P.B., Moos, P.J., Kelly, R.C., Fitzpatrick, F.A. Clinical Cancer Research, 2002, 8:846.
- Electrophilic Prostaglandins and Lipid Aldehydes Repress Redox-sensitive Transcription Factors p53 and Hypoxia-inducible Factor by Impairing the Selenoprotein Thioredoxin Reductase. Moos, P.J., Edes, K., Cassidy, P.B., Massuda, E., Fitzpatrick, F.A. J Biol Chem. 2003, 278:745.
- Characteristics of Selenazolidine Prodrugs of Selenocysteine: Toxicity and Glutathione Peroxidase Induction in V79 Cells. Short, M.D., Xie, Y., Li, L., Cassidy, P.B., Roberts, P.B. J. Med. Chem. 2003, 46, 3308.
- Conditional Expression of 15-Lipoxygenase-1 Inhibits the Selenoenzyme Thioredoxin Reductase. Yu, M.K., Moos, P.J., Cassidy, P.B., Wade, M., Fitzpatrick, F.A. J Biol Chem. 2004, 279, 28028.
- Evaluation of a 7-Day Continuous Intravenous Infusion of Decitabine: Inhibition of Promoter-Specific and Global Genomic DNA Methylation. Samlowski, W.E., Leachman, S., Wade, M., Cassidy, P.B., Porter-Gill, P., Busby, L., Wheeler, R., Fitzpatrick, F.A., Jones, D.A., Karpf, A. J. Clin. Oncol. 2005, 23, 3897.
- Thioredoxin reductase partial inactivation is required for p53 inhibition by endogenous electrophiles. Cassidy, P.B., Edes, K., Nelson, C.C., Parsawar, K., Fitzpatrick, F.A., Moose, P.J. Carcinogenisis, 2006, 27, 2538-2549.
- N-Acetylcysteine Protects Melanocytes against Oxidative Stress-damage and Delays Onset of Ultraviolet-induced Melanoma in Mice. Cotter, M.A., Thomas, J., Cassidy, P.B., Robinette, K., Jenkins, N, Forell, S.R., Leachman, S., Samlowski, W.E., Grossman, D. Clin Cancer Res. 2007, 3, 5952-5958.
- The use of N-acetyl cysteine to protect melanocytic nevi against UV-induced oxidative stress: towards a novel paradigm for melanoma chemoprevention. Goodson, A.G., Cotter, M.A., Cassidy, P.B., Wade, M., Florell, S.R., Liu, T., Boucher, K., Grossman D. Clin Cancer Res. 2009 (accepted).
- Prodrugs and Conjugates of Thiol-and Selenol-containing Compounds and Methods of Use Thereof. Roberts, J.C., Wilmore, B.H., Cassidy, P.B., Dominick, P.K., Short, M.D. United States 6, 340,746, 2002.
