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Linda S. Book, M.D.

Chief, Division of Pediatric Gastroenterology

Clinical Details

Schedule An Appointment Clinical Office Address
(801) 662-2900 Primary Children's Hospital
Pediatric Gastroenterology
100 N Mario Capecchi Drive
Salt Lake City, UT 84113

Bio

Dr. Linda Book graduated from the University of Cincinnati College of Medicine, completed a pediatric residency at Cincinnati Children’s Medical Center and the University of Utah followed by fellowship training in Pediatric Gastroenterology at the University of Utah. She is Chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition, Professor of Pediatrics, and Program Director for the Pediatric Liver Transplant Program and Liver Center at Primary Children’s Medical Center.

She has an extensive clinical practice at Primary Children’s Medical Center where she cares for infants, children and adolescents with liver disease as well as those needing before and after liver transplant care. She is recognized by Best Doctors for her clinical excellence.

Her research interests have been celiac disease, gastroesophageal reflux in infants and children, and gastrointestinal problems of premature infants. Her current research focus is pediatric liver disease and transplantation.

Dr. Book has held numerous national leadership positions in pediatric gastroenterology, in the American Academy of Pediatrics, Study of Pediatric Liver Transplantation and North American Society for Pediatric Gastroenterology Hepatology and Nutrition. She has also received several national and regional awards for clinical, research, and education accomplishments.

Board Certification and Academic Information

Academic Departments Pediatrics - Professor
Academic Divisions Pediatric Gastroenterology
Board Certification American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Ped Gastroenterology)
National Board of Medical Examiners
Pediatric Transplant Hepatolgoy - Subspecialty

Academic Profile

Research Interests

  • Celiac Disease
  • Biliary Atresia
  • Pediatric Liver Disease

Board Certification and Academic Information

Academic Departments Pediatrics - Professor
Academic Divisions Pediatric Gastroenterology
Board Certification American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Ped Gastroenterology)
National Board of Medical Examiners
Pediatric Transplant Hepatolgoy - Subspecialty

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 662-2900 Primary Children's Hospital
Pediatric Gastroenterology
100 N Mario Capecchi Drive
Salt Lake City, UT 84113

Academic Bio

Dr. Linda Book graduated from the University of Cincinnati College of Medicine, completed a pediatric residency at Cincinnati Children’s Medical Center and the University of Utah followed by fellowship training in Pediatric Gastroenterology at the University of Utah. She is Chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition, Professor of Pediatrics, and Program Director for the Pediatric Liver Transplant Program and Liver Center at Primary Children’s Medical Center.

She has an extensive clinical practice at Primary Children’s Medical Center where she cares for infants, children and adolescents with liver disease as well as those needing before and after liver transplant care.

Research accomplishments include describing the endemic nature of necrotizing enterocolitis in premature infants and the utility of pH probe testing in pediatric gastroesophageal reflux, genetic and clinical associations in celiac disease. Current research interests are biliary liver disease and pediatric liver transplantation. She is serving on the NIH Data Safety Monitoring Boards for the study of cholestatic liver disease and study of liver disease in cystic fibrosis.

She received the American Academy of Pediatrics Utah Chapter Service to Children Award and the American Academy of Pediatrics Murray Davidson Award, which recognizes clinical, teaching and research excellence in pediatric gastroenterology. She was recently named to the Hall of Honor of the Cincinnati Children’s Hospital Medical Center. Dr. Book has held numerous national leadership positions in pediatric gastroenterology in the American Academy of Pediatrics, Study of Pediatric Liver Transplantation and North American Society for Pediatric Gastroenterology Hepatology and Nutrition.

Education

Education History

Type School Degree
Fellowship University of Utah School of Medicine
Cystic Fibrosis
Fellow
Fellowship University of Utah School of Medicine
Nutrition
Fellow
Fellowship University of Utah School of Medicine
Pediatric Gastroenterology
Fellow
Residency University of Utah School of Medicine
Pediatrics
Resident
Internship Children's Hospital of Cincinnati
Pediatrics
Intern
Professional Medical University of Cincinnati
Medicine
M.D.
Undergraduate Marietta College

Publications

Selected Provider Publications

Journal Article

  1. Rollins MD, Ward RM, Jackson WD, Mulroy CW, Sencer CP, Ying, J, Greene T, Book LS (2013). Effect of decreased parenteral soybean lipid emulsion on hepatic function in infants at risk for parenteral nutrition-associated liver disease: A pilot study. J Pediatr Surg, 48, 1348-1356.
  2. Deneau M, Jensen MK, Holmen J, Williams MS, Book LS, Guthery LS (2013). Primary Sclerosing Cholangitis, Autoimmune Hepatitis and Overlap in Utah Children: Epidemiology and natural History. Hepatology, 00(00).
  3. Moore JC, Thompson K, Lafleur B, Book LS, Jackson WD, OGorman MA, Black RE, Downey E Jr, Johnson DG, Matlak ME, Meyers RL, Scaife E, Guthery SL (2011). Clinical variables as prognostic tools in pediatric-onset ulcerative colitis: a retrospective cohort study. Inflamm Bowel Dis, 17(1), 15-21.
  4. Martin SR, Alvarez F, Anand R, Song C, Yin W, SPLIT Research Group (2011). Outcomes in children who underwent transplantation for autoimmune hepatitis. Liver Transpl, 17(4), 393-401.
  5. Kim RD, Book L, Haafiz A, Schwartz JJ, Sorensen JB, Gonzalez-Peralta RP (2011). Liver transplantation in a 7-month-old girl with Caroli's disease. J Pediatr Surg, 46(8), 1638-41.
  6. Rollins MD, Scaife ER, Jackson WD, Meyers RL, Mulroy CW, Book LS (2010). Elimination of soybean lipid emulsion in parenteral nutrition and supplementation with enteral fish oil improve cholestasis in infants with short bowel syndrome. Nutr Clin Pract, 25(2), 199-204.
  7. Jaskowski TD, Donaldson MR, Hull CM, Wilson AR, Hill HR, Zone JJ, Book LS (2010). Novel screening assay performance in pediatric celiac disease and adult dermatitis herpetiformis. J Pediatr Gastroenterol Nutr, 51(1), 19-23.
  8. Donaldson MR, Book LS, Leiferman KM, Zone JJ, Neuhausen SL (2008). Strongly positive tissue transglutaminase antibodies are associated with Marsh 3 histopathology in adult and pediatric celiac disease. J Clin Gastroenterol, 42(3), 256-60.
  9. Ng VL, Fecteau A, Shepherd R, Magee J, Bucuvalas J, Alonso E, McDiarmid S, Cohen G, Anand R, Studies of Pediatric Liver Transplantation Research Group (2008). Outcomes of 5-year survivors of pediatric liver transplantation: report on 461 children from a north american multicenter registry. Pediatrics, 122(6), e1128-35.
  10. Garner CP, Ding YC, Steele L, Book L, Leiferman K, Zone JJ, Neuhausen SL (2007). Genome-wide linkage analysis of 160 North American families with celiac disease. Genes Immun, 8(2), 108-14.
  11. Donaldson MR, Firth SD, Wimpee H, Leiferman KM, Zone JJ, Horsley W, OGorman MA, Jackson WD, Neuhausen SL, Hull CM, Book LS (2007). Correlation of duodenal histology with tissue transglutaminase and endomysial antibody levels in pediatric celiac disease. Clin Gastroenterol Hepatol, 5(5), 567-73.
  12. Tsou VM, Baker R, Book L, Hammo AH, Soffer EF, Wang W, Comer GM (2006). Multicenter, randomized, double-blind study comparing 20 and 40 mg of pantoprazole for symptom relief in adolescents (12 to 16 years of age) with gastroesophageal reflux disease (GERD). Clin Pediatr (Phila), 45(8), 741-9.
  13. Donaldson M, Book L, Zone J, Neuhausen S (2006). Strongly Positive Tissue Transglutaminase Antibodies Are Associated With Marsh 3 Histopathology in Adult and Pediatric Disease. Journal of Clinical Gastroenterology.
  14. Meyers RL, Book LS, OGorman MA, White KW, Jaffe RB, Feola PG, Hedlund GL (2004). Percutaneous cholecysto-cholangiography in the diagnosis of obstructive jaundice in infants. J Pediatr Surg, 39(1), 16-8.
  15. Book L, Zone JJ, Neuhausen SL (2003). Prevalence of celiac disease among relatives of sib pairs with celiac disease in U.S. families. Am J Gastroenterol, 98(2), 377-81.
  16. Lowichik A, Book L (2003). Pediatric Celiac Disease: Clinicopathologic and Genetic Aspects. Pediatr Dev Pathol.
  17. Meyers R, Book L, OGorman M, Jackson D, Black R, Downey E, Johnson D, Matlak M, Scaife E (2003). High dose Steroids, Ursodeoxycholic Acid, and Chronic IV Antibiotics Improve Bile Flow after Kasai Procedure in Infants with Biliary Atresia. Journal of Pediatric Surgery, 38(3), 406-411.
  18. Book L, Lowichik A (2003). Pediatric Celiac disease in the 21st century. MTA Pediatria, XXIV(9), 325-333.
  19. Neuhausen SL, Feolo M, Camp NJ, Farnham J, Book L, Zone JJ (2002). Genome-wide linkage analysis for celiac disease in North American families. Am J Med Genet, 111(1), 1-9.
  20. Book L, Hart A, Black J, Feolo M, Zone JJ, Neuhausen SL (2001). Prevalence and clinical characteristics of celiac disease in Downs syndrome in a US study. Am J Med Genet, 98(1), 70-4.
  21. Neuhausen SL, Feolo M, Farnham J, Book L, Zone JJ (2001). Linkage analysis of HLA and candidate genes for celiac disease in a North American family-based study. BMC Med Genet, 2(1), 12.
  22. Lewis C, Book L, Black J, Sawitzke A, Cannon-Albright L, Zone J, Neuhausen S (2000). Celiac disease and human leukocyte antigen genotype: accuracy of diagnosis in self-diagnosed individuals, dosage effect, and sibling risk. J Pediatr Gastroenterol Nutr, 31(1), 22-7.
  23. Bousvaros A, Leichtner AM, Book L, Shigeoka A, Bilodeau J, Semeao E, Ruchelli E, Mulberg AE (1996). Treatment of pediatric autoimmune enteropathy with tacrolimus (FK506). Gastroenterology, 111(1), 237-43.

Review

  1. Book LS (2002). Diagnosing celiac disease in 2002: who, why, and how? [Review]. Pediatrics, 109(5), 952-4.

Book Chapter

  1. Book L (2002). Abdominal Distention in Children. In L Osborne & T Witte (Ed.), Pediatrics for the Clinician. New York: Harcourt Press.
  2. Book L (2002). Abdominal Pain in Children. In L Osborne & T Witte (Ed.), Pediatrics for the Clinician. New York : Harcourt Press.
  3. Book L (2002). Ascites and Peritonitis in Children. In L Osborne & T Witte (Ed.), Pediatrics for the Clinician. New York: Harcourt Press.
  4. Book L (2002). Viral Hepatitis and Cholecystitis in Children. In L Osborne & T Witte (Ed.), Pediatrics for the Clinician. New York : Harcourt Press.

Case Report

  1. Martin T, Schwartz J, Demetris A, Comstock J, Lowichik A, Book L (2011). Plasmapheresis treatment of antibody-mediated rejection in an A2 donor to O pediatric liver transplant recipient. Pediatr Transplant, 15(1), E15-8.

Abstract

  1. Neuhausen S, Book L, Black J, Feola G, Farnham J, Zone J (2000). Linkage Study of Eleven Candidate Genes with Association of 7P15-P14 in Celiac Disease in a U.S. Family-Based Study. Presented to the World Congress of Pediatric Gastroenterology and Nutrition: August 5th [Abstract]. Journal of Pediatric Gastroenterology and Nutrition, 31(2), 1079.
  2. Gunasekaran T, Pan W, Torres-Pinedo R, Book L, Gremse D, Steffen R, Czinn S, Chiu Y, Pilmer B, Fitzgerald J (2000). Pharmacokinetics of Lansoprazole in Adolescent Patients with Gastroesophageal Reflux Disease (GERD). Presented at the American Gastroenterology Association: May 10th [Abstract]. Gastroenterology, 118(4), 5683.

Clinical Trials

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