Patient Rating:

No Rating Available?

Dean Y. Li, M.D., Ph.D.

Chief Scientific Officer for U of U Health Sciences

Associate VP for Research, University of Utah Health Sciences

Director, Molecular Medicine Program

Interim Co-Chair, Department of Physiology

Vice Dean for Research, School of Medicine

Patient Rating:

No Rating Available?

Specialties

Languages

  • English

Clinical Details

Schedule An Appointment Clinical Office Address
(801) 584-1235 Veterans Administration Medical Center
500 S Foothill Blvd
Salt Lake City, UT 84149

Specialties

Bio

Dr. Li is Associate Vice President for Research and Chief Scientific Officer for University of Utah Health Sciences, and Vice Dean for Research for the School of Medicine. Dr. Li is responsible for oversight of the research enterprise in the health sciences, including development and realization of a strategic plan for research. As Chief Scientific Officer, he is responsible for coordinating and maximizing the University’s health system investment in translational, clinical, and health care research leading to new treatments and health system innovations for patients.

Dr. Li is a distinguished scientist and internationally recognized for his groundbreaking research in vascular development and disease. In addition, Dr. Li practices general cardiology and ICU medicine, diagnosing and treating patients at the Veterans Hospital. He is the HA and Edna Benning Endowed Professor of Internal Medicine and Director of the Molecular Medicine Program and School of Medicine MD/PhD Program. He is also an Adjunct Professor of Human Genetics and Adjunct Professor of Oncological Sciences. Dr. Li received his bachelor’s degree from the University of Chicago and his graduate degrees from Washington University in St. Louis.

Board Certification and Academic Information

Academic Departments Internal Medicine - Professor
Human Genetics - Adjunct Professor
Oncological Sciences - Adjunct Professor
Academic Divisions Cardiovascular Medicine
Cancer Center Programs Cell Response & Regulation

Academic Profile

Research Interests

  • Vascular Diseases
  • Vascular Development

Board Certification and Academic Information

Academic Departments Internal Medicine - Professor
Human Genetics - Adjunct Professor
Oncological Sciences - Adjunct Professor
Academic Divisions Cardiovascular Medicine
Cancer Center Programs Cell Response & Regulation

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 587-8294 George and Dolores Eccles Institute of Human Genetics
Molecular Medicine
15 N 2030 E
Salt Lake City, UT 84112

Academic Bio

Dr. Li is Associate Vice President for Research and Chief Scientific Officer for University of Utah Health Sciences, and Vice Dean for Research for the School of Medicine. Dr. Li is responsible for oversight of the research enterprise in the health sciences, including development and realization of a strategic plan for research. As Chief Scientific Officer, he is responsible for coordinating and maximizing the University’s health system investment in translational, clinical, and health care research leading to new treatments and health system innovations for patients. Dr. Li is also Acting Chair of the Physiology Department.

Dr. Li is a distinguished scientist and internationally recognized for his groundbreaking research in vascular development and disease. His work includes studies of angiogenesis, a hallmark of most cancer, and characterization of a metastasis pathway in melanoma. In addition, Dr. Li practices general cardiology and ICU medicine, diagnosing and treating patients at the Veterans Hospital. He is the HA and Edna Benning Endowed Professor of Internal Medicine and Director of the Molecular Medicine Program and School of Medicine MD/PhD Program. He is also an Adjunct Professor of Human Genetics and Adjunct Professor of Oncological Sciences. Dr. Li is the recipient of multiple honors, including the Established Investigator Award from the American Heart Association and the Clinical Scientist Award in Translational Medicine from the Burroughs Wellcome Foundation. Dr. Li has served as a reviewer for the AHA and for several NIH study sections. He is a member of the American Society for Clinical Investigation and the Association of American Physicians. He is the author of multiple manuscripts published in peer-reviewed journals, including Science and Nature. Dr. Li is a current member of the AHA and NAVBO, co-founder of Hydra Biosciences, and founder of Navigen. Dr. Li’s broad experience and expertise in bench science, clinical medicine and biotechnology, combined with his success as a leader and mentor, enable him to have a major impact on the University’s health sciences mission to advance science and translate discoveries into clinical applications and better health care for patients. Dr. Li received his bachelor’s degree from the University of Chicago and his graduate degrees from Washington University in St. Louis.

Education

Education History

Type School Degree
Fellowship University of Utah School of Medicine
Cardiology
Fellow
Fellowship Barnes Hospital
Cardiology
Fellow
Residency Barnes Hospital
Resident
Professional Medical Washington University
M.D.
Doctoral Training Washington University
Ph.D.
Undergraduate University of Chicago
B.A.

Publications

Selected Provider Publications

Journal Article

  1. Wang H, Jiang Y, Shi D, Quilliam LA, Chrzanowska-Wodnicka M, Wittchen ES, Li DY, Hartnett ME (2014). Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization. FASEB J, 28(1), 265-74.
  2. Yu J, Zhang X, Kuzontkoski PM, Jiang S, Zhu W, Li DY, Groopman JE (2014). Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway. Cell Communication and Signaling, 12(1), 25.
  3. Donato AJ, Lesniewski LA, Stuart D, Walker AE, Henson G, Sorensen L, Li DY, Kohan DE (2014). Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure and vascular reactivity and affects vascular development. Life Sci, 14(00004-6), doi: 10.1016.
  4. Ranganathan P, Jayakumar C, Navankasattusas S, Li DY, Kim IM, Ramesh G (2014). UNC5B receptor deletion exacerbates tissue injury in response to AKI. J Am Soc Nephrol, 25(2), 223-49.
  5. Frech T De Domenico I, Murtaguh MA, Revelo MP, Li DY, Sawitzke AD, Drakos SG (2013). Autophagy is a key feature in the pathogenesis of systemic sclerosis. Rheumatol Int, 34(3), 435-9.
  6. Zhang B, Xiao W, Qiu H, Zhang F, Moniz HA, Jaworski A, Condac E, Gutierrez-Sanchez G, Heiss C, Clugston RD, Azadi P, Greer JJ, Bergmann C, Moremen KW, Li DY, Linhardt RJ, Esko JD, Wang L (2013). Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest, 124(1), 209-21.
  7. Mleynek TM, Li DY (2013). Maintaining the plexus: SYNJ2BP as a novel regulator of angiogenesis. Circ Res, 113(11), 1186-8.
  8. Wever-Pinzon O, Drakos SG, Kfoury AG, Nativi JN, Gilbert EM, Everitt M, Alharethi R, Brunisholz K, Bader FM, Li DY, Selzman CH, Stehlik J (2013). Morbidity and Mortality in Heart Transplant Candidates Supported with Mechanical Circulatory Support. Is Reappraisal of the Current UNOS Thoracic Organ Allocation Policy Justified? Circulation, 127(4), 452-62.
  9. Wever-Pinzon O, Selzman CH, Drakos SG, Saidi A, Stoddard GJ, Gilbert EM, Labedi M, Reid BB, Davis ES, Kfoury AG, Li DY, Stehlik J, Bader F (2013). Pulsatility and the Risk of Non-Surgical Bleeding in Patients Supported With the Continuous-Flow Left Ventricular Assist Device HeartMate II. Circ Heart Fail, 6(3), 517-26.
  10. Wever-Pinzon O, Kfoury AG, Selzman CH, Li DY, Stehlik J, Drakos SG (2013). Reply: left ventricular assist devices in chronic heart failure: more questions than answers? J Am Coll Cardiol, 62(23), 2257-8.
  11. Grossman, AH, Yoo, JH, Clancy, J, Sorensen, LK, Sedgewick, A, Tong, ZZ, Ostanin, K, Rogers, A, Grossman KF, Tripp, SR, Thomas, KR, DSouza-Schorey, C, Odelberg, SJ, Li DY (2013). The Small GTPase ARF6 Regulates ß-catenin Transactivation during WNT5A-Mediated Melanoma Invasion and Metastasis. Sci Signal, 6(265), doi: 10.1126.
  12. Wang L, He F, Bu J, Liu X, Du W, Dong J, Cooney JD, Dubey SK, Shi Y, Gong B, Li J, Mc Bride PF, Jia Y, Lu F, Soltis KA, Lin Y, Namburi P, Liang C, Sundaresan P, Paw BH, Li DY, Phillips JD, Yang Z (2012). ABCB6 mutations cause ocular coloboma. Am J Hum Genet, 90(1), 40-8.
  13. Larrieu-Lahargue F, Welm AL, Bouchecareilh M, Alitalo K, Li DY, Bikfalvi A, August P (2012). Blocking Fibroblast Growth Factor Receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. PLoS ONE, 7(6), e39540.
  14. Zhu W, London NR, Gibson CC, Davis CT, Tong ZZ, Sorensen LK, Shi DS, Guo J, Smith MCP, Grossman AH, Thomas KR, Li DY (2012). Interleukin receptor activates a MyD88-ARNO-ARF6 cascade to disrupt vascular stability. Nature, 492(7428), 252-5.
  15. Zhang X, Yu J, Kuzontkoski PM, Zhu W, Li DY, Groopman JE (2012). Slit2/Robo4 signaling modulates HIV-1 gp120-Induced lymphatic hyperpermeability. PLoS Pathog, (1).
  16. Prasad A, Kuzontkoski PM, Shrivastava A, Zhu W, Li DY, Groopman JE (2012). Slit2N/Robo1 Inhibit HIV-gp120-Induced Migration and Podosome Formation in Immature Dendritic Cells by Sequestering LSP1 and WASp. PLoS ONE, 7(10), e48854..
  17. Sawada J, Urakami T, Li F, Urakami A, Zhu W, Fukuda M, Li DY, Ruoslahti E, Komatsu M (2012). Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels. Cancer Cell, 2(22), 235-49.
  18. Frech TM, Revelo MP, Drakos SG, Murtaugh MA, Markewitz BA, Sawitzke AD, Li DY (2012). Vascular Leak is a Central Feature in the Pathogenesis of Systemic Sclerosis. J Rheumatol, 39(7), 1385-91.
  19. Niebel B, Weiche B, Mueller AL, Li DY, Karnowski N, Famulok M (2011). A luminescent oxygen channeling biosensor that measures small GTPase activation. Chem Commun (Camb), 47(26), 7521-3.
  20. Jiang Z, Luttrell I, Li DY, Yang CC, Chitaley K (2011). Altered bladder function in elastin-deficient mice at baseline and in response to partial bladder outlet obstruction. BJU Int, 110(3), 413-9.
  21. Shi Y, Qu J, Zhang D, Zhao P, Zhang Q, Tam PO, Sun L, Zuo X, Zhou X, Xiao X, Hu J, Li Y, Cai L, Liu X, Lu F, Liao S, Chen B, He F, Gong B, Lin H, Ma S, Cheng J, Zhang J, Chen Y, Zhao F, Yang X, Chen Y, Yang C, Lam DS, Li X, Shi F, Wu Z, Lin Y, Yang J, Li S, Ren Y, Xue A, Fan Y, Li D, Pang CP, Zhang X, Yang Z (2011). Genetic Variants at 13q12.12 are associated with high myopia in the Han Chinese population. Am J Hum Genet, 88(6), 805-13.
  22. Wythe, JD, Jurynec, MJ, Urness, LD, Jones CA, Sabeh MK, Werdich AA, Sato M, Yose HJ, Grunwald DJ, MacRae CA, Li DY (2011). HADP1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Dis Model Mech, 4(5), 607-21.
  23. Alvira CM, Guignabert C, Kim YM, Chen C, Wang L, Duong TT, Yeung RS, Li DY, Rabinovitch M (2011). Inhibition of transforming growth factor β worsens elastin degradation in a murine model of Kawasaki disease. Am J Pathol, 178(3), 1210-20.
  24. Lim AH, Suli A, Yaniv K, Weinstein B, Li DY, Chien CB (2011). Motoneurons are essential for vascular pathfinding. Development, 138(17), 3847-57.
  25. Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY (2011). Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest, 121(5), 1871-81.
  26. Larrieu-Lahargue F, Welm AL, Thomas KR, Li DY (2011). Netrin-4 Activates Endothelial Integrin {alpha}6{beta}1. Circ Res, 109(7), 770-4.
  27. Wilson BD, Gibson CC, Sorensen LK, Guilhermier MY, Clinger M, Kelley LL, Shiu YT, Li DY (2011). Novel approach for endothelializing vascular devices: Understanding and exploiting elastin-endothelial interactions. Ann Biomed Eng, 39(1), 337-46.
  28. Smith-Berdan S, Nguyen A, Hassanein D, Zimmer M, Ugarte F, Ciriza J, Li D, Garcia-Ojeda ME, Hinck L, Forsberg EC (2011). Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches. Cell Stem Cell, 8(1), 72-83.
  29. Yang Z, Tong Z, Chen Y, Zeng J, Lu F, Sun X, Zhao C, Wang K, Davey L, Chen H, London N, Muramatsu D, Salasar F, Carmona R, Kasuga D, Wang X, Bedell M, Dixie M, Zhao P, Yang R, Gibbs D, Liu X, Li Y, Li C, Li Y, Campochiaro B, Constantine R, Zack DJ, Campochiaro P, Fu Y, Li DY, Katsanis N, Zhang K (2010). Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet, 6(2), e1000836.
  30. Chen H, Zhang M, Tang S, London NR, Li DY, Zhang K (2010). Slit-Robo signaling in ocular angiogenesis. Adv Exp Med Biol, 664, 457-63.
  31. Drakos SG, Janicki L, Horne BD, Kfoury AG, Reid BB, Clayson S, Horton K, Haddad F, Li DY, Renlund DG, Fisher PW (2010). Risk factors predictive of right ventricular failure after left ventricular assist device implantation. Am J Cardiol, 105(7), 1030-5.
  32. London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY (2010). Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med, 2(23), 23ra19.
  33. Gowen BB, Julander JG, London NR, Wong MH, Larson D, Morrey JD, Li DY, Bray M (2010). Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever. Virol J, (7), 240.
  34. Hinton RB, Adelman-Brown J, Witt S, Krishnamurthy VK, Osinska H, Sakthivel B, James JF, Li DY, Narmoneva DA, Mecham RP, Benson DW (2010). Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model. Circ Res, 107(4), 549-57.
  35. De Domenico I, Zhang TY, Koening CL, Branch RW, London N, Lo E, Daynes RA, Kushner JP, Li D, Ward DM, Kaplan J (2010). Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest, 120(7), 2395-405.
  36. Drakos SG, Kfoury AG, Hammond EH, Reid BB, Revelo MP, Rasmusson BY, Whitehead KJ, Salama ME, Selzman CH, Stehlik J, Clayson SE, Bristow MR, Renlund DG, Li DY (2010). Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart. J Am Coll Cardiol, 56(5), 382-91.
  37. Laarrieu-Lahargue F, Welm AL, Thomas KR, Li DY (2010). Netrin-4 induces lymphangiogenesis in vivo. Blood, 115(26), 5418-26.
  38. Marlow R, Binnewies M, Sorensen LK, Monica SD, Strickland P, Forsberg EC, Li DY, Hinck L (2010). Vascular Robo-4 restricts proangiogenic VEGF signaling in breast. Proc Natl Acad Sci U S A, 107(23), 10520-5.
  39. Shibata F, Goto-Koshino Y, Morikawa Y, Komori T, Ito M, Fukuchi Y, Houchins JP, Tsang M, Li DY, Kitamura T, Nakajima H (2009). Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype. Stem Cells, 27(1), 183-90.
  40. Whitehead KJ, Chan AC, Navankasattusas S, Koh W, London NR, Ling J, Mayo AH, Drakos SG, Jones CA, Zhu W, Marchuk DA, Davis GE, Li DY (2009). The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med, 15(2), 177-84.
  41. London NR, Whitehead KJ, Li DY (2009). Endogenous endothelial cell signaling systems maintain vascular stability. Angiogenesis, 12(2), 149-58.
  42. Drakos SG, Kfoury AG, Kotter JR, Reid BB, Clayson SE, Selzman CH, Stehlik J, Fisher PW, Merida M 3rd, Eckels DD, Brunisholz K, Horne BD, Stoker S, Li DY, Renlund DG (2009). Prior human leukocyte antigen-allosensitization and left ventricular assist device type affect degree of post-implantation human leukocyte antigen-allosensitization. J Heart Lung Transplant, 28(8), 838-42.
  43. Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, Li DY (2009). Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol, 11(11), 1325-31.
  44. Pezet M, Jacob MP, Escoubet B, Gheduzzi D, Tillet E, Perret P, Huber P, Quaglino D, Vranckx R, Li DY, Starcher B, Boyle WA, Mecham RP, Faury G (2008). Elastin haploinsufficiency induces alternative aging processes in the aorta. Rejuvenation Res, 11(1), 97-112.
  45. Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama YS, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, Li DY (2008). Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med, 14(4), 448-53.
  46. Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K (2008). Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A, 105(19), 6998-7003.
  47. Shaut CAE, Keen DR, Sorensen LK, Li DY (2008). HOXA13 is essential for placental vascular patterning and labyrinth endothelial specification. PLoS Genet, 4(5), e1000073.
  48. Yockman JW, Kastenmeier A, Erickson HM, Brumbach JG, Whitten MG, Albanil A, Li DY, Kim SW and Bull DA (2008). Novel polymer carriers and gene constructs for treatment of myocardial ischemia and infarction. J Control Release, 132(3), 260-6.
  49. Navankasattusas S, Whitehead K, Suli A, Sorensen LK, Lim A, Zhao J, Thomas KR, Chien C, Li DY (2008). The netrin receptor, Unc5b, promote angiogenesis in specific vascular beds. Development, 153(4), 659-667.
  50. Wagenseil JE, Knutsen RH, Li DY, Mecham RP (2007). Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture. Am J Physiol Heart Circ Physiol, 293(1), H574-82.
  51. Jones C, London N, Park K, Chen H, Stockton R, Nishiya N, Ginsberg M, Zhang K, Li DY (2007). Robo4 signaling inhibits pathologic retinal vascular leak and neovascularization. Curr Opin Genet Dev, 135, 659-667.
  52. Wachi H, Sato F, Hakazawa J, Nonaka R, Szabo Z, Urban Z, Tasubaga T, Maeda, I, Okamoto K, Starcher, B, Li DY, Mecham R, Seyama Y (2006). Domains 16 and 17 of tropoelastin in elastic fiber formation. Biochemistry, 402(1), 63-70.
  53. Wagenseil JE, Nerurkar NL, Knutsen RH, Okamoto RJ, Li DY, Mecham RP (2005). Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries. Am J Physiol Heart Circ Physiol, 289(3), H1209-17.
  54. Park KW, Urness LD, Senchuk MM, Colvin CJ, Wythe JD, Chien CB, Li DY (2005). Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4. Dev Dyn, 234(3), 726-31.
  55. Wilson, B, Park, KW, Li, M, Suli, A, Koch, GA, Sorensen, L, Urness, L, Chien, CB, Losordo D, Li DY (2005). Netrins promote developmental and therapeutic angiogenesis. Science, 313, 640-4.
  56. Bedell V, Yeo, SY, Park, KW, Chung, J, Seth P, Shivalingappa V, Zhao, J, Obara, T, Sukhatme V, Drummond I, Chitnis A, Li DY, Ramchandran R (2005). Robo4 is essential for angiogenesis in vivo. Proc Natl Acad Sci U S A, 102(18), 6373-6378.
  57. Whitehead K, Plummer N, Adams J, Marchuk D, Li DY (2004). Ccm1 is required for arterial morphogenesis: implications for the etiology of cavernous malformation. Development, 131(6), 1437-48.
  58. Park KW, Crouse D, Lee M, Karnik S, Sorenson L, Kuo C, Li DY (2004). The axonal attractant, netrin-1, is a potent angiogenic factor. Proc Natl Acad Sci U S A, 101, 16210-5.
  59. Karnik SK, Brooke BS, Bayes-Genis A, Sorensen L, Wythe JD, Schwartz RS, Keating MT, Li DY (2003). A critical role for elastin signaling in vascular morphogenesis and disease. Development, 130(2), 411-23.
  60. Sorensen LK, Brooke BS, Li DY, Urness LD (2003). Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor. Dev Biol, 261(1), 235-50.
  61. Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY (2003). Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev Biol, 261(1), 251-67.
  62. Faury G, Pezet M, Knutsen RH, Boyle WA, Heximer SP, McLean SE, Minkes RK, Blumer KJ, Kovacs A, Kelly DP, Li DY, Starcher B, Mecham RP (2003). Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. J Clin Invest, 112(9), 1419-28.
  63. Karnik S, Wythe J, Sorenson L, Li DY (2003). Elastin induces myofibrillinogenesis in vascular smooth muscle cells. Matrix Biol, 22 (5), 409-425.
  64. Harris KM, Li DY, LEcuyer P, Moon KET, German M, Fraser V, Barzilai B (2003). The prospective role of tranesophageal echocardiography in the diagnosis and management of patients with suspected infective endocarditis. Echocardiography, 20, 576-62.
  65. Urness LD, Sorensen LK, Li DY (2000). Arteriovenous malformations in mice lacking activin-like kinase receptor 1. Nat Genet, 26, 328-331.
  66. Wendel D, Taylor D, Keating AK, Li DY (2000). Elastin maintains branching morphogenesis in the lung. Am J Respir Crit Care Med, 23, 320-326.
  67. Li DY, Brooke B, Davis EC, LK Sorensen, Boak BB, Eichwald E, Mecham RP, Keating MT (1998). Elastin is an essential determinant of arterial morphogenesis. Nature, 393, 276-280.
  68. Davila V, Wong AK, Li DY, Shelton M, Lasala J, Hopkins WE, Feinberg MS, Perez JE (1995). Dobutamine stress echocardiography predicts the physiologic significance and the need for revascularization by PTCA in patients with moderate severity coronary lesions. Am J Cardiol, 76, 245-249.
  69. Bejcek BE, Li DY, Deuel TF (1989). Transformation by v-sis occurs by an internal autocrine mechanism.l. Science, 245, 1496-1499.
  70. Davis CT, Zhu W, Gibson CC, Bowman-Kirgin J, Sorensen L, Ling J, Sun H, Navankasattusas S, Li DY (In Press). ARF6 inhibition stabilizes the vasculature and enhances survival during endotoxic shock. J Immunol, 192(12), 6045-52.
  71. Ranganathan P, Jayakumar C, Li DY, Ramesh G (In Press). UNC5B receptor deletion exacerbates DSS-induced colitis in mice by increasing epithelial cell apoptosis. J Cell Mol Med, 10, doi: 10.1111.

Review

  1. Whitehead KJ, SMith MC, Li DY (2013). Arteriovenous malformations and other vascular malformation syndromes. [Review]. Cold Spring Harbor Perspectives in Medicine, 3(2).
  2. Drakos SG, Kfoury AG, Stehlik J, Selzman CH, Reid BB, Terrovitis JV, Nanas JN, Li DY (2012). Bridge to recovery: understanding the disconnect between clinical and biological outcomes. [Review]. Circulation, 126(2), 230-41.
  3. Larrieu-Lahargue F, Thomas KR, Li DY (2012). Netrin Ligands and receptors: lessons from neurons to the endothelium. [Review]. Trends in Cardiovascular Medicine, 22(2), 44-7.
  4. Drakos SG, Kfoury AG, Selzman CH, Verma DR, Nanas JN, Li DY, Stehlik J (2011). Left ventricular assist device unloading effects on myocardial structure and function: current status of the field and call for action. [Review]. Current Opinion in Cardiology, 26(3), 245-55.
  5. London NR, Li DY (2011). Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm. [Review]. Current Opinion in Hematology, 18(3), 186-90.
  6. Chan AC, Li DY, Berg MJ, Whitehead KJ (2010). Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype. [Review]. FEBS J, 277(5), 1076-83.
  7. Smith MC, Li DY, Whitehead KJ (2010). Mechanisms of vascular stability and the relationship to human disease. [Review]. Curr Opin Hematol, 17(3), 237-44.
  8. Li DY, Whitehead KJ (2010). Evaluating strategies for the treatment of cerebral cavernous malformations. [Review]. Stroke, 41(10), S92-4.

Patent

  1. Li DY (2002). Elastin Prevents Occlusion of Body Vessels by Vascular Smooth Muscle Cells. U.S. Patent No. 60/368,084. Washington, D.C.:U.S. Patent and Trademark Office.
  2. Li DY (2001). Manipulation of Arterial-Venous Identity. U.S. Patent No. 09/921,771. Washington, D.C.:U.S. Patent and Trademark Office.
  3. Li DY (2000). Elastin-Based Compositions. U.S. Patent No. 09/554,996. Washington, D.C.:U.S. Patent and Trademark Office.

Clinical Trials

Video & News