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Matthew K. Topham, M.D.

Specialties

Languages

  • English
  • Spanish

Clinical Details

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Bio

Dr. Topham has special expertise in pulmonary diseases and is board certified in pulmonary medicine. He sees inpatients at the University of Utah hospital and directs an NIH-funded laboratory at the Huntsman Cancer Institute. In the laboratory, he studies lung, colon, and prostate cancers hoping to identify new ways to treat these diseases by finding undiscovered drug targets and by developing new ways to treat cancer using existing medications.

Board Certification and Academic Information

Academic Departments Internal Medicine - Professor
Oncological Sciences - Adjunct Professor
Academic Divisions Pulmonary
Board Certification American Board of Internal Medicine (Sub: Pulm Diseases)
Cancer Center Programs Cell Response & Regulation

Academic Profile

Research Interests

  • Lipids
  • Cancer Biology

Board Certification and Academic Information

Academic Departments Internal Medicine - Professor
Oncological Sciences - Adjunct Professor
Academic Divisions Pulmonary
Board Certification American Board of Internal Medicine (Sub: Pulm Diseases)
Cancer Center Programs Cell Response & Regulation

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 585-0304 Huntsman Cancer Institute
2000 Circle of Hope
Salt Lake City, UT 84112

Academic Bio

Dr. Topham is an investigator at the Huntsman Cancer Institute where he directs a laboratory that studies lipid signaling in an effort to understand how to interrupt abnormal signaling events that may lead to cancer. Projects in his laboratory range from the discovery of potential cancer therapy targets to pre-clinical studies using mouse models of lung, colon, and prostate cancer. His goal is to take projects from bench to bedside and have a track record of success. Dr. Topham also sees patients with pulmonary diseases at the University of Utah Hospital . His clinical work provides an opportunity to link the clinical aspects of disease to his laboratory projects and allows him to teach residents and medical students. Dr. Topham also teaches and mentors a variety of clinical and basic science trainees in his laboratory. He is also a member of the Cell Response and Regulation Program. Finally, Dr. Topham is heavily involved in the classroom where he provides basic science lectures for medical and PhD students and directs courses for graduate and medical students.

Education

Education History

Type School Degree
Fellowship University of Utah School of Medicine
Pulmonary Medicine
Fellow
Residency Duke University
Internal Medicine
Resident
Professional Medical University of Utah
Medicine
M.D.
Undergraduate Stanford University
Chemistry
B.S.
Undergraduate Northwestern University

Publications

Selected Provider Publications

Journal Article

  1. Diacylglycerol kinase eta modulates oncogenic properties of lung cancer cells.Nakano T, Iravani A, Kim M, Hozumi Y, Lohse M, Reichert E, Crotty TM, Stafforini DM, Topham MK (2014). Diacylglycerol kinase eta modulates oncogenic properties of lung cancer cells. Clin Transl Oncol, 16(1), 29-35.
  2. Diacylglycerol Kinase delta Modulates Akt Phosphorylation through Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 2 (PHLPP2).Crotty TM, Nakano T, Stafforini DM, Topham MK (2013). Diacylglycerol Kinase delta Modulates Akt Phosphorylation through Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 2 (PHLPP2). J Biol Chem, 288(3), 1439-47.
  3. Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice.Xu C, Reichert EC, Nakano T, Lohse M, Gardner AA, Revelo MP, Topham MK, Stafforini DM (2013). Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice. Cancer Res, 73(9), 2806-16.
  4. Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-epsilon expression.Matsumiya T, Xing F, Ebina M, Hayakari R, Imaizumi T, Yoshida H, Kikuchi H, Topham MK, Satoh K, Stafforini DM (2013). Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-epsilon expression. J Immunol, 191(4), 1907-15.
  5. Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.Shulga YV, Anderson RA, Topham MK, Epand RM (2012). Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator. J Biol Chem, 287(43), 35953-63.
  6. Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8.Cai J, Crotty TM, Reichert E, Carraway KL 3rd, Stafforini DM, Topham MK (2010). Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8. J Biol Chem, 285(10), 6952-9.
  7. Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.Monaco ME, Creighton CJ, Lee P, Zou X, Topham MK, Stafforini DM (2010). Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity. Translational Oncology, 3(2), 91-8.
  8. Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression.Al-Salihi MA, Terrece Pearman A, Doan T, Reichert EC, Rosenberg DW, Prescott SM, Stafforini DM, Topham MK (2009). Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. Cancer Lett, 273(2), 225-32.
  9. Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.Abramovici H, Mojtabaie P, Parks RJ, Zhong XP, Koretzky GA, Topham MK, Gee SH (2009). Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. Mol Biol Cell, 20(7), 2049-59.
  10. The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha.Matsumiya T, Imaizumi T, Yoshida H, Satoh K, Topham MK, Stafforini DM (2009). The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha. J Immunol, 182(5), 2717-25.
  11. Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol.Lung M, Shulga YV, Ivanova PT, Myers DS, Milne SB, Brown HA, Topham MK, Epand RM (2009). Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol. J Biol Chem, 284(45), 31062-73.

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