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Evan Dale Abel, M.B.B.S., D.Phil.
Chief, Division of Endocrinology, Metabolism & Diabetes
Bio
Locations
| Schedule An Appointment | Clinical Office Address |
|---|---|
| (801) 581-7763 | Utah Diabetes Center 615 Arapeen Drive, Suite 100 Salt Lake City, UT 84108 |
Board Certification and Academic Information
| Academic Departments | Internal Medicine - Professor Biochemistry - Adjunct Professor Human Genetics - Adjunct Professor |
| Academic Divisions | Endocrinology and Metabolism |
| Board Certification | American Board of Internal Medicine (Sub: Endocrinology, Diabetes & Metabolism) |
Board Certification and Academic Information
| Academic Departments | Internal Medicine - Professor Biochemistry - Adjunct Professor Human Genetics - Adjunct Professor |
| Academic Divisions | Endocrinology and Metabolism |
| Board Certification | American Board of Internal Medicine (Sub: Endocrinology, Diabetes & Metabolism) |
Academic Office Locations
| Academic Office Phone Number | Academic Office Address |
|---|---|
| (801) 585-0727 | George and Dolores Eccles Institute of Human Genetics 15 N 2030 E Salt Lake City, UT 84112 |
Academic Bio
Education History
| Type | School | Degree |
|---|---|---|
| Fellowship | Harvard Medical School, Beth Israel Deaconess Medical Center Endocrinology/Metabolism |
Fellow |
| Chief Resident | Northwestern University Medical School Internal Medicine |
Chief Resident |
| Residency | Northwestern University Internal Medicine |
Resident |
| Doctoral Training | University of Oxford Physiology |
D.Phil. |
| Internship | University of the West Indies Surgery, Medicine, OBGYN, Peds, ER |
Intern |
| Professional Medical | University of the West Indies Medicine |
M.B.B.S. |
| Undergraduate | Wolmers Boys School Pre-Medicine |
Pre Med |
Selected Provider Publications
- Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. - Diabetes, 2012
- Cytosolic, but not mitochondrial, oxidative stress likely contributes to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice. 2012 - The FEBS Journal, 2012
- Early Mitochondrial Adaptations in Skeletal Muscle to Diet-Induced Obesity are Strain Dependent and Determine Oxidative Stress and Energy Expenditure but not Insulin Sensitivity - Endocrinology, 2012
- Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. - Cardiovascular Research, 2012
- Genetic Loss of Insulin Receptors Worsens Cardiac Efficiency in Diabetes - Journal of Molecular and Cellular Cardiology, 2012
- Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c,Tbx5. In Press. - Circulation Research, 2012
- NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes - Journal of Biological Chemistry, 2012
- Receptor activator of nuclear factor-κB ligand (RANKL) is a novel inducer of myocardial inflammation - Cardiovascular Research, 2012
- Regional muscle glucose uptake remains elevated 1 week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes. Journal of Endocrinological Investigation - Journal of Endocrinological Investigation, 2012
- Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. - Diabetes, 2011
- Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload. - American Journal of Physiology: Heart and Circulatory Physiology, 2011
- Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia. - Journal of Molecular and Cellular Cardiology, 2011
- Oxidative phosphorylation flexibility in the liver of mice resistant to high-fat diet-induced hepatic steatosis. - Diabetes, 2011
- PGC-1beta deficiency accelerates the transition to heart failure in pressure overload hypertrophy. - Circulation Research, 2011
- Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo. - PLoS ONE, 2011
- The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts. - IEEE Transactions on Biomedical Engineering, 2011
- Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. - Diabetes, 2011
- Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric restricted ob/ob mice. - Diabetes, 2011
- Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function. - Endocrine Journal, 2011
- Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. - Molecular and Cellular Biology, 2010
- Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. - Circulation Research, 2010
- Aberrant water homeostasis detected by stable isotope analysis. - PLoS ONE, 2010
- PPARgamma-induced cardiolipotoxicity in mice is ameliorated by PPARalpha deficiency despite increases in fatty acid oxidation. - Journal of Clinical Investigation, 2010
- Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice. - Experimental Biology and Medicine (Maywood), 2010
- Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through LXR signaling. - Diabetes, 2010
- An APPL1-AMPK Signaling Axis Mediates Beneficial Metabolic Effects of Adiponectin in the Heart. - American Journal of Physiology: Endocrinology and Metabolism, 2010
- Dietary iron restriction or iron chelation protect from diabetes and loss of beta cell function in the obese (ob/ob lep-/-) mouse. Am J Physiol Endocrinol Metab. 2010: In Press. - American Journal of Physiology: Endocrinology and Metabolism, 2010
- Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload. - Journal of Clinical Investigation, 2010
- Loss of Bradykinin Signaling Does Not Accelerate the Development of Cardiac Dysfunction in Type 1 Diabetic Akita Mice. Endocrinology. 2010: In Press. - Endocrinology, 2010
- Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding. - Cardiovascular Research (electronic), 2009
- The role of mPer2 clock gene in glucocorticoid and feeding rhythms. - Endocrinology, 2009
- Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. - Circulation, 2009
- Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction. - Journal of Molecular and Cellular Cardiology, 2009
- Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. - Circulation Research, 2009
- Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. - Journal of Neuroscience Online, 2009
- Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases. - The Journal of Physiology, 2009
- Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. - Diabetes, 2009
- Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy. - Journal of Molecular and Cellular Cardiology, 2009
- Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. - Hypertension, 2009
- Insulin signaling regulates mitochondrial function in pancreatic beta-cells. - PLoS ONE, 2009
- Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. - American Journal of Physiology: Heart and Circulatory Physiology, 2008
- Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. - Experimental Neurology, 2008
- Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. - Circulation, 2008
- Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts. - Endocrinology, 2008
- Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. - Drug Metabolism and Disposition (electronic), 2008
- The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. - American Journal of Physiology: Heart and Circulatory Physiology, 2008
- Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. - Journal of Lipid Research, 2008
- Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. - American Journal of Physiology: Heart and Circulatory Physiology, 2008
- Reversal of oxidative stress in endothelial cells by controlled release of adiponectin. - Journal of Controlled Release, 2008
- Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. - Diabetes, 2008
- Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism. - Cell Cycle, 2008
- Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. - Molecular Endocrinology, 2008
- Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis - Molecular Medicine, 2008
- Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. - Cell Metabolism, 2007
- Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. - Diabetes, 2007
- Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling. - Endocrinology, 2007
- CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. - American Journal of Physiology: Heart and Circulatory Physiology, 2007
- PAS kinase is required for normal cellular energy balance. - Proceedings of the National Academy of Sciences of the United States of America, 2007
- A Conserved Role for Phosphatidylinositol 3-Kinase but Not Akt Signaling in Mitochondrial Adaptations that Accompany Physiological Cardiac Hypertrophy. - Cell Metabolism, 2007
- Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. - Journal of Biological Chemistry, 2006
- Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin. - American Journal of Physiology: Heart and Circulatory Physiology, 2006
- Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. - Journal of Cardiac Failure, 2006
- Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. - P L o S Biology Online, 2006
- Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1. - Cardiovascular Research, 2005
- PGC-1α deficient mice exhibit multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. - PL o S Biology, 2005
- The intrinsic circadian clock within the cardiomyocyte. - American Journal of Physiology: Heart and Circulatory Physiology, 2005
- Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action. - Journal of Biological Chemistry, 2005
- Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. - Endocrinology, 2005
- Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density. - Journal of Molecular and Cellular Cardiology, 2005
- Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. - Circulation, 2005
- Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice. - The Journal of Physiology, 2004
- Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. - Journal of Clinical Investigation, 2004
- Regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes. - Molecular Endocrinology, 2004
- Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. - American Journal of Physiology: Endocrinology and Metabolism, 2004
- Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. - Diabetes, 2004
- Optical mapping of propagation changes induced by elevated extracellular potassium ion concentration in genetically altered mouse hearts. - Journal of Electrocardiology, 2004
- Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload. - American Journal of Physiology: Heart and Circulatory Physiology, 2003
- Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone. - Molecular Endocrinology, 2003
- Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. - Journal of Clinical Investigation, 2002
- Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. - Journal of Biological Chemistry, 2002
- Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. - Endocrinology, 2001
- Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. - Nature, 2001
- An unliganded thyroid hormone receptor causes severe neurological dysfunction. - Proceedings of the National Academy of Sciences of the United States of America, 2001
- Critical role for thyroid hormone receptor beta2 in the regulation of TRH neurons in the paraventricular hypothalamus. - Journal of Clinical Investigation, 2001
- Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis. - Circulation, 2001
- Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor. - Circulation Research, 2000
- Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. - Nature Medicine, 2000
- Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. - Journal of Clinical Investigation, 1999
- Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. - Journal of Clinical Investigation, 1999
- Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin. - Journal of Clinical Investigation, 1999
- Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements. - Diabetes, 1998
- Impaired glucose tolerance in hypertension is associated with impaired insulin release independently of changes in insulin sensitivity. - Journal of Hypertension, 1994
- Leukocyte sodium content and sodium pump activity in overweight and lean hypertensives. - Clinical Endocrinology, 1989
- Mechanisms of leukocyte sodium influx in essential hypertension. - Clinical Science, 1988








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