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Camille M. Fung

Camille M. Fung, MD

Languages spoken: English, Cantonese

Clinical Locations

Intermountain Medical Center

801-507-7000

Primary Children's Hospital

Newborn Intensive Care Unit
801-662-4100

University of Utah Hospital

Newborn Intensive Care Unit
801-581-2745
  • Camille Fung, M.D. is an Associate Professor in the Division of Neonatology, Department of Pediatrics, at the University of Utah School of Medicine. In addition to caring for sick newborns in 3 level III & IV NICUs in the Salt Lake valley as a neonatologist, she has a basic science research interest in determining the effects of intrauterine growth restriction (IUGR) on hippocampal neuronal development. This is important because IUGR infants are at increased risk for cognitive delays particularly affecting learning and memory, functions that are performed by the hippocampus, but the underlying mechanisms leading to such delays remain elusive. Due to inaccessibility of fetal/neonatal brain tissue, she uses a mouse model of IUGR that she developed in 2010, which mimics human pregnancy-induced hypertension, to study embryonic and postnatal hippocampal neurogenesis and synaptic development. In addition to understanding IUGR's effects on the central nervous system (CNS), she has collaborations both within and outside of the University of Utah investigating the mechanisms of IUGR-induced retinopathy, necrotizing enterocolitis, and chronic lung disease/pulmonary hypertension. She has held a NIH-sponsored co-Investigator R01 grant on the last complication. Relating to her basic science interest on CNS function, she has quality improvement and clinical research interests on neonatal opioid withdrawal syndrome (NOWS). The incidence of NOWS has skyrocketed across the U.S., attributed to prescription opioid use and misuse. She has worked closely with interdisciplinary teams both at Intermountain and University Healthcare systems to implement a care process model on NOWS management. Working with the Utah Department of Health, she has also extended this care process model to other healthcare systems across Utah such that a standardized practice exists for infants suffering from NOWS. She is also a Principal Investigator and a co-Investigator on two NIH-funded clinical projects relating to NOWS. Lastly, recognizing the concurrent use of other substances along with prescription opioids, Dr. Fung has incepted a CME course to address the opioid epidemic since 2014 and has helped incept another course in 2020 to address the increasing use of cannabis in pregnant women. The first course satisfies the Utah Division of Professional Licensing (DOPL) requirement for opioid education mandated at each license cycle renewal and the second course satisfies the requirement to become a medical cannabis prescriber. These courses are accessible year round through the Substance Education Institute at substanceei.com. She has also mentored pediatric residents, neonatal-perinatal fellows, undergraduate and graduate students both in basic science and in clinical research.

    Specialties

    Board Certification

    American Board of Pediatrics (Pediatrics)
    American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine)
  • Camille Fung, M.D. is an Associate Professor in the Division of Neonatology, Department of Pediatrics, at the University of Utah School of Medicine. In addition to caring for sick newborns in 3 level III & IV NICUs in the Salt Lake valley as a neonatologist, she has a basic science research interest in determining the effects of intrauterine growth restriction (IUGR) on hippocampal neuronal development. This is important because IUGR infants are at increased risk for cognitive delays particularly affecting learning and memory, functions that are performed by the hippocampus, but the underlying mechanisms leading to such delays remain elusive. Due to inaccessibility of fetal/neonatal brain tissue, she uses a mouse model of IUGR that she developed in 2010, which mimics human pregnancy-induced hypertension, to study embryonic and postnatal hippocampal neurogenesis and synaptic development. In addition to understanding IUGR's effects on the central nervous system (CNS), she has collaborations both within and outside of the University of Utah investigating the mechanisms of IUGR-induced retinopathy, necrotizing enterocolitis, and chronic lung disease/pulmonary hypertension. She has held a NIH-sponsored co-Investigator R01 grant on the last complication. Relating to her basic science interest on CNS function, she has quality improvement and clinical research interests on neonatal opioid withdrawal syndrome (NOWS). The incidence of NOWS has skyrocketed across the U.S., attributed to prescription opioid use and misuse. She has worked closely with interdisciplinary teams both at Intermountain and University Healthcare systems to implement a care process model on NOWS management. Working with the Utah Department of Health, she has also extended this care process model to other healthcare systems across Utah such that a standardized practice exists for infants suffering from NOWS. She is also a Principal Investigator and a co-Investigator on two NIH-funded clinical projects relating to NOWS. Lastly, recognizing the concurrent use of other substances along with prescription opioids, Dr. Fung has incepted a CME course to address the opioid epidemic since 2014 and has helped incept another course in 2020 to address the increasing use of cannabis in pregnant women. The first course satisfies the Utah Division of Professional Licensing (DOPL) requirement for opioid education mandated at each license cycle renewal and the second course satisfies the requirement to become a medical cannabis prescriber. These courses are accessible year round through the Substance Education Institute at substanceei.com. She has also mentored pediatric residents, neonatal-perinatal fellows, undergraduate and graduate students both in basic science and in clinical research.

    Board Certification and Academic Information

    Academic Departments Pediatrics -Primary
    Academic Divisions Neonatology
    Board Certification
    American Board of Pediatrics (Pediatrics)
    American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine)

    Education history

    Fellowship Neonatology - UCLA Mattel Children's Hospital Clinical Fellow
    Developmental Biology - UCLA David Geffen School of Medicine Postdoctoral Research Fellow
    Residency Pediatrics - St. Christopher's Hosp. for Children Resident
    Pediatrics - St. Christopher's Hospital for Children Intern
    Professional Medical Jefferson Medical College M.D.
    Graduate level Cell Physiology - University of San Francisco
    Undergraduate Biology major and Chemistry minor - Santa Clara University B.S.

    Selected Publications

    Journal Article

    1. Young LW, Ounpraseuth ST, Merhar SL, Hu Z, Simon AE, Bremer AA, Lee JY, Das A, Crawford MM, Greenberg RG, Smith PB, Poindexter BB, Higgins RD, Walsh MC, Rice W, Paul DA, Maxwell JR, Telang S, Fung CM, Wright T, Reynolds AM, Hahn DW, Ross J, McAllister JM, Crowley M, Shaikh SK, Puopolo KM, Christ L, Brown J, Riccio J, Wong Ramsey K, Akshatha, Braswell EF, Tucker L, McAlmon KR, Dummula K, Weiner J, White JR, Howell MP, Newman S, Snowden JN, Devlin LA, ACT NOW Collaborative (2023). Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal. N Engl J Med.
    2. Nugent M, St Pierre M, Brown A, Nassar S, Parmar P, Kitase Y, Duck SA, Pinto C, Jantzie L, Fung C, Chavez-Valdez R (2023). Sexual dimorphism in the closure of the hippocampal postnatal critical period of synaptic plasticity after intrauterine growth restriction - link to oligodendrocyte and glial dysregulation. Dev Neurosci.
    3. Fung C, Cung T, Nelson C, Wang H, Bretz C, Ramshekar A, Brown A, Stoddard GJ, Hartnett ME (2023). Retinopathy of prematurity protection conferred by uteroplacental insufficiency through erythropoietin signaling in an experimental Murine Model. Pediatr Res.
    4. St Pierre M, Duck SA, Nazareth M, Fung C, Jantzie LL, Chavez-Valdez R (2023). Unbiased Quantitative Single-Cell Morphometric Analysis to Identify Microglia Reactivity in Developmental Brain Injury. Life (Basel), 13(4).
    5. Fung CM (2023). Effects of intrauterine growth restriction on embryonic hippocampal dentate gyrus neurogenesis and postnatal critical period of synaptic plasticity that govern learning and memory function. Front Neurosci, 17, 1092357.
    6. Chang J, Bashir M, Fung CM, Dettman R, Dizon M (2021). Intrauterine growth restriction followed by oxygen support uniquely interferes with genetic regulators of myelination. eNeuro, DOI: https://doi.org/10.1523/ENEURO.0263-20.2021.
    7. Bushati C, Chan B, Harmeson Owen A, Woodbury A, Yang M, Fung C, Lechtenberg E, Baserga M (2021). Implementing exclusive human milk diet to extremely low birth weight infants in a level III NICU. Nutr Clin Pract, doi: 10.1002/ncp.10625. Online ahead of print.
    8. Morris E, Bardsley T, Schulte K, Seidel J, Shakib JH, Buchi KF, Fung CM (2020). Hospital Outcomes of Infants with Neonatal Opioid Withdrawal Syndrome at a Tertiary Care Hospital with High Rates of Concurrent Nonopioid (Polysubstance) Exposure. Am J Perinatol, 2020 Sep 6. doi: 10.1055/s-0040-1716490. Online ahead of print.
    9. Chang JL, Santiago C, Farrow K, Fung C, Brown AS, Dettman RW, Dizon MLV (2018). Intrauterine growth restriction and hyperoxia as a cause of white matter injury. Dev Neurosci, 40(4), 344-357.
    10. Gibbins KJ, Gibson-Corley KN, Brown AS, Wieben M, Law RC, Fung CM (2017). Effects of excess thromboxane A2 on placental development and nutrient transporters in a Mus musculus model of fetal growth restriction. Biol Reprod, 98(5), 695-704.
    11. Xie Y, Kaufmann D, Moulton M, Panahi S, Gaynes JA, Zhou D, Xue H, Fung C, Levine EM, Letsou A, Brennan KC, Dorsky RI (2017). Lef1-dependent hypothalamic neurogenesis inhibits anxiety. PLoS Biol, 15(8), e2002257.
    12. McKnight RA, Yost CC, Zinkhan EK, Fu Q, Callaway CW, Fung CM (2016). Intrauterine growth restriction inhibits expression of eukaryotic elongation factor 2 kinase, a regulator of protein translation. Physiol Genomics, 48(8), 616-25.
    13. Fung CM, White JR, Brown AS, Gong H, Weitkamp JH, Frey MR, McElroy SJ equal contribution (2016). Intrauterine growth restriction alters mouse intestinal architecture during development (PMID 26745886). PLoS One, 11(1), e0146542.
    14. McKnight RA, Yost CC, Yu X, Wiedmeier JE, Callaway CW, Brown AS, Fung CM (2015). Intrauterine growth restriction perturbs nucleosome depletion at a growth hormone responsive element in the mouse IGF1 gene (PMID 26487705). Physiol Genomics, Epub.
    15. Fung CM, Yang Y, Fu Q, Brown AS, Yu B, Callaway CW, Li J, Lane RH, McKnight RA equal contribution (2015). IUGR prevents IGF-1 upregulation in juvenile male mice by perturbing postnatal IGF-1 chromatin remodeling (PMID 25826117). Pediatr Res.
    16. Zinkhan EK, Lang BY, Yu B, Wang Y, Jiang C, Fitzhugh M, Dahl MJ, Campbell MS, Fung C, Malleske D, Albertine KH, Joss-Moore L, Lane RH (2014). Maternal tobacco smoke increased visceral adiposity and serum corticosterone levels in adult male rat offspring (PMID 24727947). Pediatr Res, 76(1), 17-23.
    17. Fung C, Ke X, Brown AS, Yu X, McKnight RA, Lane RH equal contribution (2012). Uteroplacental insufficiency alters rat hippocampal cellular phenotype in conjunction with ErbB receptor expression (PMID 22367251). Pediatr Res, 71(4-2), 1-8.
    18. Fung C, Brown A, Cox J, Callaway CW, McKnight RA, Lane RH (2011). Novel thromboxane A2 analog-induced IUGR mouse model (PMID 25141265). J Dev Orig Health Dis, 2(5), 291-301.
    19. Fung C, Shin D, Shin BC, Sankar R, Chaudhuri G, Devaskar SU (2010). Hypoxic-ischemic brain injury exacerbates neuronal apoptosis and precipitates spontaneous seizures in glucose transporter Isoform 3 heterozygous null mice (PMID 20857507). J Neurosci Res, 88(15), 3386-3398.
    20. Fung C, Zhao Y, Shin D, Shin BC, Thamotharan S, Sankar R, Ehninger D, Silva A, and Devaskar SU equal contribution (2010). Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders (PMID 19506559). Mol Psychiatry, 15(3), 286-299.

    Review

    1. Fung C, McKnight RA, Lane RH (2013). Environmental influences on epigenetic gene regulation. [Review]. Neoreviews, 14(3), e121-e127.

    Book Chapter

    1. Fung C, Zinkhan E (2021). Short and long term implications of small for gestational age. In Blue N.R. and Silver R. (Eds.), Obstetrics and Gynecology Clinics (https://doi.org/10.1016/j.ogc.2021.02.004, pp. 311-323). Elsevier.
    2. Fung CM, Devaskar SU (2006). Nutrient Regulation In Brain Development: Glucose and Alternate Fuels. In Hay W (Ed.), Neonatal Nutrition and Metabolism (Second Edition). Cambridge University Press.

    Case Report

    1. Malone Jenkins S, Cipriano S, Fung C (2016). Rash under phototherapy in a two day old preterm male. Neoreviews.

    Video/Film/CD/Web/Podcast

    1. Fung C, Buchi KF (2020). Marijuana Use During Pregnancy and Breastfeeding [Web].
    2. Fung C (03/06/2018). Mitigating the Opioid Epidemic in Pregnant Women and Newborn Infants on a Shoestring Budget [Web]. Philadelphia: ReachMD. Available: https://reachmd.com/programs/lifelong-learning/mitigating-the-opioid-epidemic-in-pregnant-women-and-newborn-infants-on-a-shoestring-budget/10021/.
    3. Munson K (10/31/2017). A State of Addiction: Utah's Opioid Epidemic. A 13-part series on Utah Public Radio. Interview with Dr. Camille Fung [Podcast]. Logan: Utah State University. Available: https://www.upr.org/programs/state-addiction-utahs-opioid-epidemic.