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Amnon Schlegel, M.D., Ph.D.

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Clinical Details

Phone Number Clinical Office Address
(801) 581-7761
Utah Diabetes Center
615 Arapeen Drive, Suite 100
Salt Lake City, UT 84108
(801) 582-1565
Veterans Administration Medical Center
500 S Foothill Blvd
Salt Lake City, UT 84149

Bio

Dr. Schlegel sees patients with lipid disorders and type 2 diabetes mellitus requiring complex medical therapy at the Utah Diabetes and Endocrinology Center. He sees patients with all endocrine and metabolic disorders at the Endocrinology clinic at the George E. Wahlen Department of Veterans Affairs Medical Center. Dr. Schlegel also serves as a General Medicine ward attending physician (annual fortnight) at the George E. Wahlen Department of Veterans Affairs Medical Center; and performs one month annually of in-patient Endocrinology consultations at the University of Utah Medical Center (including Huntsman Cancer Hospital and Neuropsychiatric Institute).

Board Certification and Academic Information

Academic Departments Internal Medicine - Associate Professor
Biochemistry - Adjunct Associate Professor
Academic Divisions Endocrinology and Metabolism
Board Certification American Board of Internal Medicine (Internal Medicine)
American Board of Internal Medicine (Sub: Endocrinology, Diabetes & Metabolism)

Academic Profile

Research Interests

  • Zebrafish
  • Lipids
  • Biochemistry
  • Hormones
  • Ketone Bodies
  • Kinase
  • Monocarboxylate Transporter
  • Molecular Genetics
  • Adipose Tissue
  • Diabetes Mellitus
  • Non-alcoholic Fatty Liver Disease
  • Obesity
  • Endocrinology

Board Certification and Academic Information

Academic Departments Internal Medicine - Associate Professor
Biochemistry - Adjunct Associate Professor
Academic Divisions Endocrinology and Metabolism
Board Certification American Board of Internal Medicine (Internal Medicine)
American Board of Internal Medicine (Sub: Endocrinology, Diabetes & Metabolism)

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 585-0730 George and Dolores Eccles Institute of Human Genetics
15 N 2030 E
Salt Lake City, UT 84112

Academic Bio

Dr. Schlegel was a trainee in the Medical Scientist Training Program of the Albert Einstein College of Medicine where he received his M.D. and Ph.D. He was an intern and resident physician at Beth Israel Deaconess Medical Center in Boston, MA, and was a Fellow in Medicine at Harvard Medical School. He was a clinical fellow in the Diabetes, Endocrine, and Metabolism Training Program at the University of California San Francisco, where he was subsequently a post-doctoral associate in the laboratory of Professor Didier Y.R. Stainier, Ph.D., in the Department of Biochemistry and Biophysics. It was there that he established a zebrafish molecular genetic system for studying lipid metabolism.

In 2010, Dr. Schlegel was recruited to the University of Utah as an investigator in the Molecular Medicine Program and as an Assistant Professor of Internal Medicine and Biochemistry. He was promoted to Associate Professor with award of tenure in 2016. He hosts graduate students in his lab through the Molecular Biology and Biological Chemistry Graduate programs. His laboratory uses model organisms (zebrafish and mice) to identify and characterize new genes that participate in lipid metabolism. The long-term goal of this work is to identify novel therapeutic targets for treating obesity, type 2 diabetes, and lipid disorders.

Research Statement

My laboratory takes a multi-pronged approach to identifying and characterizing novel genes involved in lipid and glucose metabolism. Starting with unbiased, forward genetic screens in zebrafish, we isolate mutants with lipid phenotypes of interested (e.g., inappropriate accumulation of lipids in the liver, altered adipose lipid mass). We then clone and characterize the affected genes. We also use modern genetic methods to delete or selectively express genes of therapeutic interest, with a particular emphasis on the control of intestinal lipid handling as a platform for treating dyslipidemia and atherosclerosis. We take similar approaches to elucidating the roles of gene identified in human population genetics studies in glucose metabolism and type 2 diabetes mellitus pathogenesis. Characterization of mutant and transgenic zebrafish involves a broad range of methods spanning sophisticated microscopy (confocal and transmission electron), biochemical techniques, and, where appropriate, pilot pharmacological studies. We use in vitro enzymology, cell culture (including primary culture of human hepatocytes), and rodent (mice and rats) physiology to complement our work in zebrafish.

Education

Education History

Type School Degree
Fellowship University of California, San Francisco
Diabetes, Endocrinology and Metabolism
Fellow
Residency Beth Israel Deaconess Medical Center
Internal Medicine
Resident
Internship Beth Israel Deaconess Medical Center
Internal Medicine
Intern
Doctoral Training Albert Einstein College of Medicine
Medical Scientist Training Program, Department of Molecular Pharmacology
Ph.D.
Professional Medical Albert Einstein College of Medicine
Medicine
M.D.
Undergraduate Hofstra University
Biochemistry
B.S.

Publications

Selected Provider Publications

Journal Article

  1. Karanth S, Zinkhan EK, Hill JT, Yost HJ, Schlegel A (2016). FOXN3 regulates hepatic glucose utilization. Cell Rep, 15(12), 2745-2755.
  2. Safavi-Hemami H, Gajewiak J, Karanth S, Robinson SD, Ueberheide B, Douglass A, Schlegel A, Imperial J, Watkins M, Bandyopadhyay PK, Yandell M, Li Q, Purcell AW, Norton RS, Ellgaard L, Olivera BM (2015). A specialized insulin is used for chemical warfare by fish-hunting cone snails. Proc Natl Acad Sci U S A, 112(6), 1743-1748.
  3. Cruz-Garcia L, Schlegel A (2014). Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids. J Lipid Res, 55(9), 1944-1958.
  4. Karanth S, Tran VM, Kuberan B, Schlegel A (2013). Polyunsaturated fatty acyl-Coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Dis Model Mech, 6(6), 1365-1377.
  5. Hugo SE, Cruz-Garcia L, Karanth S, Anderson RM, Stainier DYR, Schlegel A (2012). A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Genes Dev, 26(3), 282-293.

Review

  1. Schlegel A, Gut P (2015). Metabolic Insights from Zebrafish Genetics, Physiology, and Chemical Biology. [Review]. Cellular and Molecular Life Sciences, 72(12), 2249-2260.
  2. Schlegel, A (2012). Studying nonalcoholic fatty liver disease with zebrafish-- a confluence of optics, genetics, and physiology. [Review]. Cellular and Molecular Life Sciences, 69(23), 3965-3961.
  3. Schlegel A, Stainier DY (2007). Lessons from "lower" organisms: what worms, flies, and zebrafish can teach us about human energy metabolism. [Review]. PLoS Genet, 3(11), e199.

Global Impact

Global Impact

Selected Provider Publications

Journal Article

  1. Safavi-Hemami H, Gajewiak J, Karanth S, Robinson SD, Ueberheide B, Douglass A, Schlegel A, Imperial J, Watkins M, Bandyopadhyay PK, Yandell M, Li Q, Purcell AW, Norton RS, Ellgaard L, Olivera BM (2015). A specialized insulin is used for chemical warfare by fish-hunting cone snails. Proc Natl Acad Sci U S A, 112(6), 1743-1748.
    Global Impact: Australia.

Clinical Trials

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