Patient Rating:

4.7 out of 5

49 Patient Ratings
34 Patient Comments

K.C. Brennan, M.D.

Patient Rating:

4.7 out of 5

49 Patient Ratings
34 Patient Comments



  • English
  • French
  • Portuguese
  • Spanish

Clinical Details

Schedule An Appointment Clinical Office Address
(801) 585-7575 Imaging and Neurosciences Center
Headache Clinic
729 Arapeen Way
Salt Lake City, UT 84108


K.C. Brennan, MD, is a clinician scientist who specializes in the treatment of headache. disorders. His lab studies the basic mechanisms of migraine and post-traumatic headache.

Board Certification and Academic Information

Academic Departments Neurology - Assistant Professor
Neurobiology and Anatomy - Adjunct Assistant Professor
Academic Divisions Headache and Neuro-Ophthalmology
Board Certification American Board of Psychiatry & Neurology

Patient Ratings

The Patient Rating score is an average of all responses to care provider related questions on our nationally-recognized Press Ganey Patient Satisfaction Survey.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Likelihood of recommending care provider
My confidence in care provider
Time care provider spent with me
Care provider spoke using clear language
Care provider's effort to include me in decisions
Care provider's concern for questions & worries
Care provider's explanation of condition/problem
Wait time at clinic
Care provider's friendliness and courtesy

Patient Comments

Patient comments are gathered from our Press Ganey Patient Satisfaction Survey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

November 19, 2014

Excellent and caring doctor! I appreciate how concerned Dr. Brennan is with the botox treatments. He tries to make sure that each injection is placed where I can get the most pain relief from this treatment! ;)

September 08, 2014

dr Brennan was awesome. he talks to you in words that u can understand and makes sure that you do before proceeding. he is constantly asking if u r ok during the procedure. u have complete confidence in Dr. Brennan.

August 17, 2014

Dr. Brennan is a very kind, courteous and likeable person. He addressed my concerns and wanted to make sure that I was happy with the botox procedure and wanted to know of any areas in my head/neck/back that would benefit from the treatments that I needed for my migraines.

August 04, 2014

Dr Brennan is outstanding. He is so easy to communicate with and truly listens to what I have to say. I wish more doctors were like him.

July 05, 2014

Have all ready recommended DR BRENNAN

June 02, 2014

dr Brennan was awesome. he explained the procedure as he went. I was extremely happy with dr. Brennan.

April 28, 2014

I think Dr. Brennan is the best! He is awesome!

April 28, 2014

Dr Brennan is down to earth, easy to talk to. I rate him very highly.

April 14, 2014

Dr. Brennan seemed a bit rushed that day. I travel 5 hours each way and spend the night in a hotel each time I see Dr. Brennan since he is a specialist that I trust. It's important to me to have time to ask questions and discuss the treatment.

March 06, 2014

All Good

February 05, 2014

As an established patient of Dr. Digre's this wasn't my first visit to the clinic; however, it was my first visit with Dr. Brennan for Botox and he was very informative and answered all my questions very thoroughly.

January 27, 2014

had concerns about medication and felt like it wasn't addressed effectively

December 31, 2013

Dr. Brennan spent extra time with me to carefully go over my medications and PT to make sure that I'm doing all I can to improve my health. I really appreciate his attention and concern.

December 28, 2013

Dr. Brennan was incredibly caring and helpful. He always cares a great deal about my Botox injections and their efficacy, but he also made great efforts to help relieve my immediate pain.

December 21, 2013

extremely positive experience

October 21, 2013

Please introduce the role of the resident/fellow who comes into the room with scheduled physician. It was not clear to me that the physician that I was scheduled for is not the one who would perform the procedure.

October 14, 2013

he always takes great care to make sure that he places the injections the the best places

October 07, 2013

I thought the doctor was very good, very personable and knowledgeable. I felt very comfortable during my appointment.

September 09, 2013

Dr. Brennan was very nice and took the time to explain medications and other treatment options for my headaches. I was impressed with how long he spent with me and never seemed rushed. He took the time to answer any questions and throughly explained my treatment plan, and the other services the clinic provides. Thanks!

August 22, 2013


August 14, 2013

Dr. Brennan is knowledgeable, caring and genuine.

August 14, 2013

Dr Brennan was amazing and spent extra time with me explaining lots of different things. I appreciated it.

August 12, 2013

dr Brennan went above&beyond spending extra time explaining procedures and other related things.

July 16, 2013

Dr. Brennan and the staff are always excellent.

June 25, 2013

Dr. Brennan was very short with me when I was trying to give him my medical history. He kept saying he had to go and seemed very impatient. It took almost two years for me to finally get an appt. and I think he should have acted more patient with me. He seemed knowledgeable however.

March 11, 2013

First time meeting and having patient care with Dr. Brennan. Found him to be very likeable, professional, and informative. Was very at ease with his care during my procedure.

December 03, 2012

His confidence in his diagnosis was comforting but really threw us off balance because we did not think it would be so easy without an MRI.

November 27, 2012

He let me know exactly what he was doing and why. I felt very comfortable with the injections I was getting because he knew so much about them and informed me about as much as he knew. I would have to say it was the best doctors visit I have had.

October 04, 2012

Dr. Brennan has been an excellent provider throughout our experiences with him. He has provided the only lasting relief she has received after years of trying many treatments. We understand that her headaches are very complicated and impossible to cure, but Dr. Brennan has our complete confidence and has met with a good measure of success.

October 04, 2012

Very caring about my situation. Nice to have this experience with a doctor.

July 09, 2012

We are just grateful that you have accepted our case and hope you can resolve the problem so wecan get back to work and live a normal/productive life again.

May 18, 2012

EVerything was excellent. We appreciate being given the opportunity to participate in this experimental treatment.

February 14, 2012

Dr. Brennan was wonderful

February 03, 2012

Dr. Brennan was very clear and concise with what needs to happen and I appreciate him explains things so well on a level that I could understand.

Academic Profile

Research Interests

  • Cortical Spreading Depression
  • Migraine
  • Headache Disorders

Board Certification and Academic Information

Academic Departments Neurology - Assistant Professor
Neurobiology and Anatomy - Adjunct Assistant Professor
Academic Divisions Headache and Neuro-Ophthalmology
Board Certification American Board of Psychiatry & Neurology

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 581-8129 Brain Institute
383 Colorow Drive
Salt Lake City, UT 84108

Academic Bio

Dr. K.C. Brennan is Assistant Professor of Neurology at the University of Utah School of Medicine. He was educated at Georgetown University and the Columbia College of Physicians and Surgeons.

Dr. Brennan's clinical practice is dedicated to the headache disorders. These conditions, which include migraine, cluster headache, and post-traumatic headache, are disabling, often stigmatized, and poorly understood. It is becoming increasingly clear that these disorders are not 'just headache,' but complex disruptions of brain excitability and homeostasis.

Dr. Brennan spends much of his time examining the basic mechanisms of migraine and post-traumatic headache. His lab uses a variety of techniques, in animal models and in patients, to understand the neural circuit disruptions that cause an otherwise normal nervous system to produce pain.


Education History

Type School Degree
Other Training Cold Spring Harbor Laboratory Summer Course
Imaging Structure and Function in the Nervous System
Fellowship David Geffen School of Medicine at UCLA, Department of Neurology
Headache, Neurophysiology
Residency David Geffen School of Medicine at UCLA
Internship George Washington University Medical Center
Internal Medicine
Professional Medical Columbia University College of Physicians and Surgeons
Certification Georgetown University
Post-Baccalaureate Pre-Medical Sciences
Undergraduate Georgetown University
School of Foreign Service


Selected Provider Publications

Journal Article

  1. Chang J, Brennan K, He D, Huang H, Miura R, Wilson P, Wylie J (Summer 2013). A Mathematical Model of the Metabolic and Perfusion Effects on Cortical Spreding Depression. PLoS ONE.
  2. Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptacek LJ (2013). Casein kinase 1 delta mutations in familial migraine and advanced sleep phase. Sci Transl Med, 1(5), 1-11.
  3. Clarkson AN, Lopez-Valdes HE, Overmann JJ, Charles AC, Brennan KC, Thomas Carmichael S (2013). Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model. J Cereb Blood Flow Metab, 33(5), 716-723.
  4. Bogdanov VB, Bogdanov OV, Koulchitsky SV, Chauvel V, Multon S, Makarchuk MY, Brennan KC, Renshaw PF, Schoenen J (01/01/2013). Behavior in the open field predicts the number of KCl-induced cortical spreading depression in rats. Behav Brain Res, 236, 90 - 93.
  5. Theriot JJ, Toga AW, Prakash N, Ju, YS, Brennan KC (In Press). Cortical sensory plasticity in a model of migraine with aura. J Neurosci, 32(44), 15252-61.
  6. Ahn AH, Brennan KC (2012). Unanswered questions in headache: how does a migraine attack stop? Headache, 52(1), 186-7.
  7. Chang JC, Brennan KC, Chou T (2011). Tracking monotonically advancing boundaries in image sequences using graph cuts and recursive kernel shape priors. IEEE Trans Med Imaging, PMC2215697.
  8. Tang YT, Kim J, Lopez-Valdes HE, Brennan KC, Ju YS (2011). Development and characterization of a microfluidic chamber incorporating fluid ports with active suction for localized chemical stimulation of brain slices. Lab Chip, 11(13), 2247-54.
  9. Chang JC, Shook LL, Biag J, Nguyen EN, Toga AW, Charles AC, Brennan KC (2010). Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression. Brain, 133(Pt 4), 996-1012.
  10. Bates EA, Nikai T, Brennan KC, Fu YH, Charles AC, Basbaum AI, Ptacek LJ, Ahn AH (2010). Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia, 30(2), 170-8.
  11. Lopez-Valdes HE, Beltran-Parrazal L, Brennan KC, Charles AC (2010). Bradykinin increases resensitization of purinergic receptor signaling in glioma cells. Cancer Cell Int, 10, 35.
  12. Charles A, Flippen C, Romero Reyes M, Brennan KC (2007). Memantine for prevention of migraine: a retrospective study of 60 cases. J Headache Pain , 8(4), 248-50.
  13. Brennan KC, Beltran-Parrazal L, Lopez-Valdes HE, Theriot J, Toga AW, Charles AC (2007). Distinct vascular conduction with cortical spreading depression. J Neurophysiol, 97(6), 4143-51.
  14. Brennan KC, Romero Reyes M, Lopez Valdes HE, Arnold AP, Charles AC (2007). Reduced threshold for cortical spreading depression in female mice. Ann Neurol, 61(6), 603-6.
  15. Beltran-Parrazal L, Lpez-Valds HE, Brennan KC, Daz-Muoz M, de Vellis J, Charles AC (2006). Mitochondrial transport in processes of cortical neurons is independent of intracellular calcium. Am J Physiol Cell Physiol, 291(6), C1193-7.
  16. Brennan KC, Jurewicz EC, Ford B, Pullman SL, Louis ED (2002). Is essential tremor predominantly a kinetic or a postural tremor? A clinical and electrophysiological study. Mov Disord, 17(2), 313-6.
  17. Sakai N, Brennan K, Weiss L, Matile S (1997). Toward Biomimetic Ion Channels Formed by Rigid-Rod Molecules: Length-Dependent Ion-Transport Activity of Oligo(p-Phenylene)s. J Am Chem Soc, 119, 8726-8727.


  1. Digre KB, Brennan KC (In press). Shedding light on photophobia. [Review]. Journal of Neuro-Ophthalmology.
  2. Brennan KC, Charles A (2010). An update on the blood vessel in migraine. [Review]. Current Opinion in Neurology, 23(3), 266-74.
  3. Charles A, Brennan KC (2010). The neurobiology of migraine. [Review]. Handb Clin Neurol, 97, 99-108.
  4. Charles A, Brennan K (2009). Cortical spreading depression-new insights and persistent questions. [Review]. Cephalalgia, 29(10), 1115-24.
  5. Brennan KC, Charles A (2009). Sleep and headache. [Review]. Semin Neurol, 29(4), 406-18.
  6. Matsumoto J, Saver JL, Brennan KC, Ringman JM (2005). Mitochondrial encephalomyopathy with lactic acidosis and stroke (MELAS). [Review]. Reviews in Neurological Diseases, 2(1), 30-4.

Book Chapter

  1. Charles A, Brennan KC (2010). The neurobiology of migraine. In Handb Clin Neurol (97, pp. 99-108).
  2. Brennan KC, Toga AW (2009). Intraoperative optical imaging. In Frostig R (Ed.), Methods for in vivo Optical Imaging of the Central Nervous System. CRC Press.
  3. CharlesAC, Brennan KC (2008). Glial cell calcium signaling. In Squire L (Ed.), Encyclopedia of Neuroscience. Elsevier Press.
  4. Brennan KC, Charles AC (2008). Mechanisms of cortical spreading depression as targets for migraine therapy. In OlesenJ, Ramadan N (Ed.), Frontiers in Headache Research: Innovative Drug Development for Headache Disorders. Oxford University Press.

Conference Proceedings

  1. Tang YT, Kim J, Lopez-Valdes H, Brennan KC, Ju YS (January 24th-28th, 2010). Microfluidic Chamber with Active Suction Ports for Localized Chemical Stimulation of Brain Slices. Proceedings of IEEE 23rd International Conference on Micro Electro Mechanical Systems. Hong Kong, China, 304-307.


  1. Brennan KC, Ahn AH (2013). Unanswered questions in headache: So what is photophobia, anyway? Headache, 53(10), 1673-4.
  2. Brennan KC (2011). Turn down the lights! An irritable occipital cortex in migraine without aura. Neurology, 76(3), 206-7.
  3. Charles A, Brennan KC (2008). A touch of increased pain: cutaneous allodynia in migraine. Ann Neurol, 63(2), 130-2.
  4. Charles A, Brennan KC (2007). Sumatriptan-naproxen combination for acute migraine. Nat Clin Pract Neurol, 3(11), 604-5.


  1. Brennan KC, Kaufmann D, Bates EA, Bahr S, and White HS (11/02/2012). Anti-migraine properties of Sec-butyl propylacetamide (SPD): a novel valproic acid amide analogue. Annual Snowbird Neuroscience Symposium. Salt Lake City, UT [Abstract].
  2. KC Brennan, MD, Theriot J, Prakash N, Toga A (9/27/2012). Potentiation and sharpening of sensory maps after spreading depression: a possible mechanism for altered sensorium in migraine [Abstract].
  3. Bogdanov VB, Misyura AG, Mammilov S, Multon S, Schoenen J, Brennan KC (06/24/2012). Differential susceptibility and propagation of spreading depression by cortical depth. American Headache Society 54th Annual Meeting. Los Angeles, CA [Abstract].
  4. Brennan KC, Chang JC, Chou T, He D, Huang H, Miura RM, Wilson PL, and Wylie J (6/24/12). Interconnected neural, vascular, and metabolic dysfunction during cortical spreading depression: a mathematical model. American Headache Society 54th Annual Scientific Meeting. Los Angeles, CA [Abstract].
  5. Brennan KC, Tanga YT, Lpez-Valdsb HE, Charles A, and Ju YS (06/24/2012). Minimum conditions for the induction of cortical spreading depression American Headache Society 54th Annual Scientific Metting. Los Angeles, CA [Abstract].
  6. Brennan KC, Theriot J, Toga A, Prakash N, Ju YS (2011). Increased signal-to-noise in the sensory cortex after spreading depression: a possible mechanism for altered sensory perception in migraine. 15th Annual Congress of the International Headache Society, Berlin, Germany. Selected for Platform Presentation [Abstract].
  7. KC Brennan, Bogdanov V, Chang J, Multon S, Schultz N, Zyuzin J, van den Maagdenberg Arn, Charles A, Schoenen J (2010). Anisotropy of cortical spreading depression: implications for migraine. 52nd Annual Meeting of the American Headache Society. Los Angeles, CA. Selected for Platform Presentation [Abstract].
  8. Brennan KC, Chang J, Shook L, Biag J, Nguyen E, Toga AW, Charles AC (2009). Biphasic DC shift, hemoglobin desaturation, and neurovascular uncoupling in cortical spreading depression. 134th Annual Meeting of the American Neurological Association, Baltimore MD. Selected for Platform Presentation [Abstract].


  1. Brennan K, Digre K, Baggaley S (2012). Headache- A Patient's Guide.

Clinical Trials

Clinical Trials

Video & News