Granulomatosis with polyangiitis (Wegener's granulomatosis)

Wegener’s Granulomatosis

Wegener’s granulomatosis is a condition of the immune system that causes swelling and irritation in blood vessels and other tissues.

This inflammation reduces or stops the flow of blood to organs in the body. The condition most often affects the respiratory tract–the sinuses, nose, windpipe, and lungs–and the kidneys, but it can damage any organ in the body.

Wegener’s granulomatosis is uncommon. It occurs in about one out of 20,000 to 30,000 people. It can strike at any age. The cause of Wegener’s granulomatosis is still unknown.

Signs and symptoms

Most people with Wegener’s granulomatosis first report vague symptoms that may include:

  • Tiredness or exhaustion
  • Joint pain
  • Upper respiratory symptoms that don’t respond to treatments for allergies or colds:
    • Runny nose
    • Bloody discharge
    • Sinus pain
    • Congestion
    • Blockage of the eustachian tubes in the ears
    • Cough
    • Cough that produces blood
    • Shortness of breath
  • Eye infections, redness, burning, or pain
  • Weakness
  • Skin sores or ulcers
  • Hoarseness
  • Fever
  • Night sweats

When to call a doctor

Call your doctor if you are experiencing the symptoms listed above, especially if you have tried over-the-counter treatments that seem appropriate, such as allergy medications, with no success.

Always call your doctor if you have changes in vision or a cough that produces bloody mucus, which may be symptoms of Wegener’s granulomatosis or another serious health condition.


Your doctor visit may include:

  • Taking your medical history
  • Physical exam
  • Review of your symptoms
  • Blood tests. These can’t diagnose Wegener’s granulomatosis, but they can rule out other causes of your symptoms.
  • Antineurtophil cytoplasmic antibody (ANCA) blood test. In addition to routine blood tests, health care providers will often look for this specific antibody, but a positive or negative test does not confirm the diagnosis. 
  • Imaging tests, such as chest X-rays or CT scans of the lungs or sinus
  • Biopsy, or taking a sample of tissue from an affected organ to see whether the condition is present. This is the only way to know for sure if it’s
  • Wegener’s granulomatosis.
  • Urine tests


Most people with Wegener’s granulomatosis will find relief. But the drugs used to treat this condition all have potential side effects of their own. Be sure to discuss these side effects in detail with your doctor.

University Hospital
Clinic 2
50 N Medical Drive East
Salt Lake City, UT 84132
Phone number:
(801) 581-7724