Please note that this section reports on claims that have NOT yet been substantiated through scientific studies.
There is conflicting evidence that taking glycine orally in addition to conventional treatment seems to reduce negative symptoms of schizophrenia in patients who are resistant to monotherapy with conventional antipsychotics.
Applying a cream containing glycine, l-cysteine, and dl-threonine seems to reduce pain and slightly improve healing of leg ulcers.
Taking glycine sublingually may have neuroprotective effects if started within six hours after the onset of acute ischemic stroke. In addition, it is thought to be useful in treating depression, hyperactivity, and malnutrition associated with drug addiction.
Amino acids (AAs), such as glycine, are available as individual AAs or in proprietary AA combinations, as well as part of multi-vitamin formulas, proteins, and food supplements. The forms include tablets, fluids, and powders. However, adequate protein in the diet should provide a sufficient source of all amino acids.
There are no conditions that increase the nutritional requirements for glycine.
Side effects, toxicity, and interactions
The use of a single amino acid supplement may lead to a negative nitrogen balance, decreasing the metabolic efficiency and increasing the workload of the kidneys. In children, taking single amino acid supplements may also harmfully affect growth parameters.
Excessive glycine in the body has been linked to seizure disorders and developmental delays in children.
Always avoid taking individual amino acids in high dosage for prolonged periods.
Women who are pregnant or breastfeeding should not use glycine supplements.
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