Trimethobenzamide Hydrochloride Oral capsule

What is this medicine?

TRIMETHOBENZAMIDE (trye meth oh BEN za mide) helps to control nausea and vomiting after surgery. This medicine is also used to control nausea caused by stomach problems.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • an unusual or allergic reaction to trimethobenzamide, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

This medicine may also interact with the following medications:

  • alcohol

  • atropine, belladonna alkaloids, hyoscyamine, scopolamine

  • barbiturates, like phenobarbital

  • medicines for sleep or anxiety

  • medicines for pain

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

If your condition gets worse after taking this medicine, contact your health care professional immediately.

You may get drowsy or dizzy or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase side effects of this medicine. Avoid alcoholic drinks.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • shakiness or tremors

  • seizures

  • severe or continuing vomiting

  • sore throat or fever

  • swelling of the hands and feet

  • tightness in the chest

  • yellowing of the eyes or skin

  • unusually tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • headache

  • muscle cramps

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.


Trimethobenzamide Hydrochloride Rectal suppository

What is this medicine?

TRIMETHOBENZAMIDE (trye meth oh BEN za mide) helps to control nausea and vomiting after surgery. This medicine is also used to control nausea caused by stomach problems.

NOTE: This drug is no longer available in the United States. Patients currently using Trimethobenzamide suppositories should contact their prescriber about stopping this medicine and finding alternative therapies.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • an unusual or allergic reaction to trimethobenzamide, benzocaine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for rectal use only. Do not take by mouth. Wash your hands before and after use. Take off the foil wrapping. Wet the tip of the suppository with cold tap water to make it easier to use. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach. Lift upper buttock to expose the rectal area. Apply gentle pressure to insert the suppository completely into the rectum, pointed end first. Hold buttocks together for a few seconds. Remain lying down for about 15 minutes to avoid having the suppository come out. Do not use more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for certain conditions, precautions do apply. This medicine should not be used in infants or premature infants.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

This medicine may also interact with the following medications:

  • alcohol

  • atropine, belladonna alkaloids, hyoscyamine, scopolamine

  • medicines for pain

  • medicines for sleep or anxiety

  • phenobarbital or other barbiturates

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

If your condition gets worse after taking this medicine, contact your health care professional immediately.

You may get drowsy or dizzy or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase side effects of this medicine. Avoid alcoholic drinks.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • shakiness or tremors

  • seizures

  • severe or continuing vomiting

  • sore throat or fever

  • swelling of the hands and feet

  • tightness in the chest

  • yellowing of the eyes or skin

  • unusually tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • headache

  • muscle cramps

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused portion after the expiration date.


Trimethobenzamide Hydrochloride Solution for injection

What is this medicine?

TRIMETHOBENZAMIDE (trye meth oh BEN za mide) helps to control nausea and vomiting after surgery. This medicine is also used to control nausea caused by stomach problems.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • an unusual or allergic reaction to trimethobenzamide, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

This medicine may also interact with the following medications:

  • alcohol

  • atropine, belladonna alkaloids, hyoscyamine, scopolamine

  • barbiturates, like phenobarbital

  • medicines for pain

  • medicines for sleep or anxiety

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

You may get drowsy, dizzy, or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase possible dizziness or drowsiness. Avoid alcoholic drinks.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • shakiness or tremors

  • seizures

  • severe or continuing vomiting

  • sore throat or fever

  • swelling of the hands and feet

  • tightness in the chest

  • unusually tired

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • headache

  • muscle cramps

  • pain at site where injected

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.