Phenylpropanolamine extended-release tablets or capsules

What are phenylpropanolamine extended-release tablets or capsules?

PHENYLPROPANOLAMINE (Prolamine®, Phenyldrine®, Dexatrim®, Acutrim®) is a decongestant. It can help relieve nasal or sinus congestion (stuffiness). Combined with a reduced calorie diet, it can help you to lose weight by decreasing your appetite. Generic phenylpropanolamine extended-release tablets and capsules are available.

NOTE: This drug is discontinued in the United States.

What should my health care professional know before I take phenylpropanolamine?

They need to know if you have any of the following conditions:

  • blood vessel disease

  • diabetes

  • difficulty urinating (urinary retention)

  • glaucoma

  • heart disease or heart rhythm problems

  • high blood pressure

  • kidney disease

  • over active thyroid

  • prostate trouble

  • an unusual or allergic reaction to phenylpropanolamine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I take this medicine?

Take phenylpropanolamine extended-release tablets or capsules by mouth. Follow the directions on the prescription label. Swallow whole with a drink of water; do not crush or chew. Take your doses at regular intervals. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Elderly patients over 60 years old may have a stronger reaction to this medicine and need smaller doses.

What if I miss a dose?

If you miss a dose, and you are taking it on a regular schedule, take it as soon as you can. If it is almost time for your next dose (less than 2 hours), take only that dose. Do not take double or extra doses.

What drug(s) may interact with phenylpropanolamine?

  • ammonium chloride

  • amphetamine or other stimulant drugs

  • bicarbonate, citrate, or acetate products (such as sodium bicarbonate, sodium acetate, sodium citrate, sodium lactate, and potassium citrate)

  • bromocriptine

  • caffeine

  • cocaine

  • furazolidone

  • indomethacin

  • linezolid

  • medicines for colds and breathing difficulties

  • medicines for diabetes

  • medicines known as MAO inhibitors, such as phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), and selegiline (Carbex®, Eldepryl®)

  • medicines for mental depression

  • medicines for migraine

  • procarbazine

  • some medicines for chest pain, heart disease, high blood pressure or heart rhythm problems

  • some medicines for weight loss (including some herbal products, ephedrine, dextroamphetamine)

  • St. John's wort

  • theophylline

  • thyroid hormones

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check before starting or stopping any of your medicines.

What should I watch for while taking phenylpropanolamine?

If you are taking phenylpropanolamine for a cold, check with your prescriber or health care professional if your condition has not improved within 7 days, or if you have a high fever.

If nervousness, dizziness, sleeplessness, or palpitations occur, stop using phenylpropanolamine and consult a health care professional.

If phenylpropanolamine extended-release products make it difficult for you to sleep at night; take your last dose at least 12 hours before bedtime.

What side effects may I notice from taking phenylpropanolamine?

Side effects that you should report to your prescriber or health care professional as soon as possible:

Rare or Uncommon:

  • chest pain

  • confusion

  • dizziness, or fainting spells

  • numbness or tingling in the hands or feet

  • rapid or troubled breathing

  • seizures (convulsions)

  • severe, persistent, or worsening headache

More Common:

  • anxiety

  • fast or irregular heartbeat, palpitations

  • increased blood pressure

  • increased sweating

  • pain or difficulty passing urine

  • sleeplessness (insomnia)

  • tremor

  • vomiting

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • difficulty sleeping

  • dry mouth

  • headache (mild)

  • loss of appetite

  • nausea, stomach upset

  • restlessness or nervousness

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Most products should be stored below 30 degrees C (86 degrees F). Follow manufacturer's advice on storage of specific products. Throw away any unused medicine after the expiration date.


Phenylpropanolamine tablets or capsules

What are phenylpropanolamine tablets or capsules?

PHENYLPROPANOLAMINE (Propagest®, Acutrim®, Dexatrim®, and others) is a decongestant. It can help relieve nasal or sinus congestion (stuffiness). Combined with a reduced calorie diet, it can help you to lose weight by decreasing your appetite. Generic phenylpropanolamine tablets and capsules are available.

NOTE: This drug is discontinued in the United States.

What should my health care professional know before I take phenylpropanolamine?

They need to know if you have any of the following conditions:

  • blood vessel disease

  • diabetes

  • difficulty urinating (urinary retention)

  • glaucoma

  • heart disease or heart rhythm problems

  • high blood pressure

  • kidney disease

  • over active thyroid

  • prostate trouble

  • an unusual or allergic reaction to phenylpropanolamine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I take this medicine?

Take phenylpropanolamine tablets or capsules by mouth. Follow the directions on the prescription label. Swallow with a drink of water. Take your doses at regular intervals. Do not take your medicine more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Elderly patients over 60 years old may have a stronger reaction to this medicine and need smaller doses.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose (less than 2 hours), take only that dose. Do not take double or extra doses.

What drug(s) may interact with phenylpropanolamine?

  • ammonium chloride

  • amphetamine or other stimulant drugs

  • bicarbonate, citrate, or acetate products (such as sodium bicarbonate, sodium acetate, sodium citrate, sodium lactate, and potassium citrate)

  • bromocriptine

  • caffeine

  • cocaine

  • furazolidone

  • indomethacin

  • linezolid

  • medicines for colds and breathing difficulties

  • medicines for diabetes

  • medicines known as MAO inhibitors, such as phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), and selegiline (Carbex®, Eldepryl®)

  • medicines for mental depression

  • medicines for migraine

  • procarbazine

  • some medicines for chest pain, heart disease, high blood pressure or heart rhythm problems

  • some medicines for weight loss (including some herbal products, ephedrine, dextroamphetamine)

  • St. John's wort

  • theophylline

  • thyroid hormones

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check before starting or stopping any of your medicines.

What should I watch for while taking phenylpropanolamine?

If you are taking phenylpropanolamine for a cold, check with your prescriber or health care professional if your condition has not improved within 7 days, or if you have a high fever.

If nervousness, dizziness, sleeplessness, or palpitations occur, stop using phenylpropanolamine and consult a health care professional.

If phenylpropanolamine (regular-release product) makes it difficult for you to sleep at night; take the last dose of the day a few hours before bedtime.

What side effects may I notice from taking phenylpropanolamine?

Side effects that you should report to your prescriber or health care professional as soon as possible:

Rare or Uncommon:

  • chest pain

  • confusion

  • dizziness, or fainting spells

  • numbness or tingling in the hands or feet

  • rapid or troubled breathing

  • seizures (convulsions)

  • severe, persistent, or worsening headache

More Common:

  • anxiety

  • fast or irregular heartbeat, palpitations

  • increased blood pressure

  • increased sweating

  • pain or difficulty passing urine

  • sleeplessness (insomnia)

  • tremor

  • vomiting

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • difficulty sleeping

  • dry mouth

  • headache (mild)

  • loss of appetite

  • nausea, stomach upset

  • restlessness or nervousness

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Most products should be stored below 30 degrees C (86 degrees F). Follow manufacturer's advice on storage of specific products. Throw away any unused medicine after the expiration date.