The Cancer Control and Population Sciences (CCPS) Program is a comprehensive basic and applied research program that spans the cancer control continuum from etiology, primary prevention, screening, and early detection to continuing care, survivorship, and end-of-life care. The unifying long-range goals of the program are to prevent cancer and reduce cancer morbidity and mortality.
The work of the CCPS Program is organized around two central scientific themes 1) Translational Cancer Predisposition Genetics and 2) Cancer Behavioral and Outcomes Research, which are pursued using the following approaches:
Translational Cancer Predisposition Genetics (Theme 1)
CCPS Program Newsletters
CCPS 2014 Summer Newsletter
Cancer Behavioral and Outcomes Research (Theme 2)
Influence of Genetics on Behavior and Outcomes (intersection of Theme 1 and 2)
Program scientific discoveries and accomplishments include creation of a national resource linking genealogy to phenotype data, identification of two breast cancer susceptibility genes, demonstration of an interaction between smoking and alcohol consumption that can cause markedly elevated risk of upper aerodigestive tract cancers, and understanding cancer disparities in vulnerable populations within the catchment area.
The CCPS Program is co-led by Kathleen Mooney, PhD, RN, and Sean Tavtigian, PhD, who bring together members with a broad range of expertise including basic laboratory, epidemiological, socio-behavioral, clinical research on cancer risk factors and mechanisms, and intervention trial design and execution, under the shared belief that the maximal value of fundamental or basic discoveries is achieved only when research is translated into evidence-based clinical and public health strategies.
The Cancer Control and Population Sciences Program received $10.6 million in total research support from the National Institutes of Health, the American Cancer Society, the National Science Foundation, and other funding agencies in 2013, with 78% coming from the National Cancer Institute. Cancer-focused articles published between 2009-2013 total 525, of which 14% are inter-programmatic and 29% are intra-programmatic publications.
Sean V. Tavtigian, PhD
Kathleen Mooney, PhD
|Alter, Orly||Matrix and tensor modeling of large-scale molecular biological data which can be used to correctly predict previously unknown physical, cellular, and evolutionary mechanisms that govern the activity of DNA and RNA.|
|Aspinwall, Lisa||Psychological and behavioral response to genetic testing for mutations that increase cancer risk.|
Pain and symptom management; quality of life; cancer survivorship.
Diabetes, obesity, and body composition in colorectal cancer.
|Boucher, Kenneth||Cancer biostatistics||website|
Healthy levels of physical activity that might reduce trends toward overweight and risk of cancer.
|Buys, Saundra||Breast cancer genetics, cancer screening.|
Localizing genes for complex traits including increased cancer risks; evaluating genotype/phenotype relationship; developing statistical genetic methods.
Breast cancer susceptibility gene identification; disease predisposition genes with an emphasis on melanoma and prostate cancer.
|Caserta, Michael||How aspects of cancer caregiving influences health and well-being outcomes; intervening relationship with self-care practices.|
Cancer communications with breast cancer survivors.
Gene patenting, particularly the Myriad Genetics case involving the patenting of the BRCA 1/2 breast/ovarian cancer genes and alleles.
|Curtin, Karen||Genetic and epigenetic risk factors for cancer and their relationship to environmental influences.|
Substantive and methodological integration in the fields of acute and chronic pain, cancer, and quality of life in progressive disease
|Ellington, Lee||Patient-provider communication psycho- oncology.|
Methods to improve shared decision making regarding cancer screening and cancer treatment between patients and their physicians
|Fluchel, Mark||Oncology trials in pediatric patients|
Genetic studies of breast cancer and melanoma; clinical classification of BRCA1 and BRCA2.
|Hanson, Heidi||Promote healthy aging and longevity by understanding genetic and environmental determinants of health throughout the life course.|
|Hashibe, Mia||Global and molecular epidemiology of cancer||website|
|Hu, Nan||Statistical methodology in diagnostic/ prognostic study in clinical trials in survival analysis and their application to cancer diagnosis and screening.|
|Jensen, Jakob||Cancer communication; psychometric of key cancer constructs and the design and behavioral interventions.||website|
|Kaphingst, Kimberly||Communicating genetic and genomic information related to cancer risk.|
|Kepka, Deanna L.||Cervical cancer prevention and control; specifically HPV vaccination; prevention of cancer-related disparities among vulnerable populations.|
|Kirchhoff, Anne||Assessing how cancer affects social and economic outcomes for childhood cancer survivors.||website|
|LaStayo, Paul||Aging cancer patients and survivors|
|Leachman, Sancy||Melanoma genetics translation||website|
|Lee, Catherine||The evaluation of the expression and function of T cell immunoglobulin and mucin domain-3 (TIM-3), a candidate biomarker of acute myeloid leukemia stem cells.|
|Lee, Yuan-Chin (Amy)||Utilize etiological information; identify interventions; perform controlled trials; establish sustainable interventions in the population to improve cancer prevention measures and quality of life for cancer patients.|
|Leppert, Mark||Melanoma genetics translation, human genetics|
|Linder, Lauri||Symptom management for children and adolescents with an emphasis on the use of technology to support symptom assessment and interventions.|
|Collaborative research to inform access to care with a focus on integrative oncology.|
|Lowrance, William||Surgical treatment for urologic malignancies|
|Marth, Gabor||Computational biology; genomic variant identification and interpretation.|
|Matsen, Cindy||Clinical tools to address patient communication styles and methods for comprehensive risk profiling that incorporate biologic, genetic, and psychosocial risk assessment|
|Mineau, Geraldine||Epidemiology of cancer|
|Monroe, Marcus||Survivorship in head and neck and thyroid cancer; thyroid cancer risk stratification; HPV, head and neck cancers.|
|Mooney, Kathleen||Quality of life, prevention adherance behaviors, cancer symptom experience|
|Neklason, Deborah||Genetic etiology of colon cancer||website|
|Rothwell, Erin||Cancer support groups and biobehavioral models for improving quality of life for individuals diagnosed with cancer|
|Rupper, Randall||Cancer screening, diagnosis, and treatment decisions of older adults|
|Samadder, Jewel||Gastrointestinal cancer syndromes; endoscopic oncology|
|Samowitz, Wade||Colorectal cancer genetics|
|Slattery, Marty L.||Epidemiological methods, environmental and genetic factors affecting cancer development|
|Smith, Ken||Psychosocial consequences of genetic testing|
|Stenehjem, David||Oncology-related outcomes research to inform personalized health care decision-making.|
|Suneja, Gita||Identifying cancer treatment disparities in under- served populations; translating these scientific findings into health policy initiatives to improve cancer care in the U.S. and developing countries|
|Sweeney, Carol||Molecular epidemiology of cancer|
|Tavtigian, Sean V.||Identification and characterization of intermediate -risk and high-risk cancer susceptibility genes, primarily breast, ovarian and prostate.||website|
|Ulrich, Cornelia||Colorectal cancer, exercise and cancer||website|
|Wu, Yelena||Identifying the psychological and behavioral factors impacting health self-management within pediatric oncology populations, and designing interventions to improve self- management and health outcomes.||website|
Development of computational genomics tools for personalized medicine, cancer, infectious disease, population biology, agriculture, and forensics.