Cell Response and Regulation

CRR Membership Directory

cell response and regulation research programCell Response and Regulation (CRR) program conducts basic research on the fundamental cellular mechanisms that are deregulated in cancer cells. This discovery science provides new insight into cancer pathways and potential biomarkers.

The CRR program brings together scientists with shared research interests in two main thematic areas:

  • Mechanisms underlying cell turnover, including control of cell division, checkpoints, and cell death and their dysregulation in cancer in order to identify and characterize cancer targets.
  • Aberrant signaling in cancer and mechanisms of drug resistance, including signaling molecules and pathways relevant to drug resistance and cancer treatment.
  • Mechanisms and pathways mediating cell adhesion, motility, and metastasis, including developing an understanding of how cancer cells acquire the capability to reach distant sites and grow in those environments, which is critical for eventual therapeutic or preventative targeting.

CRR Program Newsletters

CRR 2013 Winter Newsletter
CRR 2013 Summer Newsletter
CRR 2012 Winter Newsletter
CRR 2012 Summer Newsletter

Program achievements include an improved understanding of the machinery that executes cell division, elucidation of signaling pathways involved in epithelial homeostasis and migration, and identification of a new biomarker for breast cancer, a critical mediator of drug resistance in myeloma, and factors that drive brain tumor and melanoma metastasis. A major asset of the CRR Program is the development of robust high-fidelity preclinical models of cancer. Basic CRR Program discoveries are leading to early phase clinical trials in breast cancer and melanoma and have impacted a chemoprevention trial in colon cancer.

The CRR Program is co-lead by Douglas Grossman, MD, PhD, and Katharine Ullman, PhD, and draws its members from many academic units on campus, providing a forum for interdepartmental communication among individuals who share a common interest in understanding the cellular basis of cancer. The CRR Program stimulates scientific exchange and promotes cancer-focused transdisciplinary research by capitalizing on opportunities to link the diverse expertise in techniques and model systems in synergistic projects. This extends across Cancer Center Programs and is further promoted by the interface with disease focus groups.

The Cell Response and Regulation Program received $9.8 million in total research support from the National Institutes of Health, the American Cancer Society, the National Science Foundation, and other funding agencies in 2013, with 34% coming from the National Cancer Institute. Cancer-focused articles published between 2009-2013 total 212, of which 37% are inter-programmatic and 18% are intra-programmatic publications.

Douglas Grossman, MD, PhD

Katharine S. Ullman, PhD

doug grossman katherine ullman

HCI, Room 5262
801-585-7477 FAX                                    

HCI, Room 5345

CRR Membership Directory 


Name E-mail Research Interests Website
Baron, Riccardo e-mail Addressing fundamental questions on the molecular origins of anticancer drug resistance; develop and apply computational chemistry to investigate the coupling among biomolecular structure, (thermo)dynamics, and function at diverse spatiotemporal scales
Beckerle, Mary e-mail Cell adhesion, cell migration, Ewing's sarcoma website
Factor, Rachel e-mail Breast cancer pathology
Frost, Adam e-mail Basic mechanisms of cellular physiology and to understand how malignancy changes these mechanisms
Fults, Daniel e-mail Defective signaling in medulloblastoma
Grossman, Douglas e-mail Apoptotic mechanisms underlying skin cancer development, with a focus on the apoptosis and cell cycle regulator, Survivin; oxidative stress in melanoma website
Holmen, Sheri e-mail Identifying and validating novel molecular targets for cancer therapy website
Li, Dean e-mail Signaling in angiogenesis; targeting angiogenesis in cancer
Lim, Carol e-mail Targeting apoptotic mechanisms in cancer cells
Moos, Philip e-mail Redox dysregulation in cancer, selenoprotein function in cancer
Murtaugh, L. Charles e-mail Pancreatic development and cancer
O'Hare, Thomas e-mail Target discovery and inhibitor development for chronic and acute leukemias; mechanism-based targeting of leukemic cells, including leukemia stem cells; design, validation, and coordination of function-first profiling for new therapeutic targets in leukemia website
Oliver, Trudy e-mail Mouse models of lung cancer; chemotherapeutic resistance; p53 regulation website
Rosenblatt, Jody e-mail Mechanisms and regulation of cell death and division. Novel mechanisms for initiating tumor cell metastasis website
Sigman, Matthew e-mail Synthesis and biological evaluation of novel small molecule platforms; mechanism of action studies of the resultant hits
Spangrude, Gerald e-mail Stem cell biology
Stafforini, Diana e-mail Role of inflammation in cancer website
Stewart, Rodney e-mail Cell survival and migration during embryogenesis and cancer website
Sundquist, Wesley e-mail Membrane trafficking and cytokinesis
Topham, Matthew e-mail Lipid signaling in cancer website
Ullman, Katharine e-mail Cell division, biomarkers and tumor suppressors in breast cancer website
VanBrocklin, Matthew e-mail Identifying novel molecular targets that can be developed for therapeutic intervention strategies website
Welm, Alana e-mail Tumor inflammation and cancer, particularly breast cancer website
Welm, Bryan e-mail Breast cancer stem cells, cancer drug screening website
Williams, Matthew e-mail Understanding of the cellular and molecular signals that regulate the differentiation and cell fate decisions of activated T cells in vivo
Zimmerman, Guy e-mail Cell adhesion and inflammation, thrombosis in cancer