Molecular Imaging Program

Grant Funding

Source: 

National Cancer Institute (NCI)

Number

R21 CA150381

Project Title

Preliminary Evaluation of FDG-PET with anti-IGF-1R Targeted Therapy in GISTs.

PI

Jeffrey T. Yap, PhD

The major goals of this multi PI project are:

  1. To test the novel therapeutic anti-IGF1R tyrosine kinase inhibitor OSI-906 in the treatment of patients with advanced GIST; 
  2. To test the ability of FDG-PET to evaluate the metabolic response to OSI-906 using FDG-PET and determine if tumor metabolic response predicts anatomic response; and
  3. To correlate levels of insulin and IGF family members and their endogenous regulators to changes in normal tissues and tumor metabolic activity as measured by FDG-PET.  This is a subcontract to
  4. Fox Chase Cancer Center.



Source: 

SARC Sarcoma SPORE

Number

 

Project Title

Project 4: Development of quantitative imaging biomarkers for assessing response to sarcoma therapy.

PI

Jeffrey T. Yap, PhD

This project seeks to develop new imaging approaches using MRI and PET to non-invasively measure various aspects of tumor biology and pathophysiology in response to conventional and experimental chemotherapies.  This will enable a powerful set of tools to evaluate treatment efficacy and ultimately improve the development of new drugs and clinical management of sarcoma patients.  This is a subcontract to SARC.



Source: 

National Institute of Biomedical Imaging and Bioengineering (NIH)

Number

R21 EB013795-01A1

Project Title

Voxelwise analysis of imaging response to therapy in neuro-oncology.

PI

Jeffrey T. Yap, PhD

The major goal of this project is to develop more objective methods for evaluation of oncology brain FDG-PET images that can indicate changes anywhere in the brain and correct for the confounding effects induced by global and regional changes in normal brain metabolism. This is achieved by a voxelwise comparison between the pre-treatment and post-treatment 3D scans, preceded by spatial registration, segmentation and background adjustment, and followed by statistical significance thresholding. This is a subcontract to North Carolina State University

 

Current Funding for CQCI Faculty

Source: 

National Cancer Institute (NIH)

Number

1-R21 CA167795-01

Project Title

Multi-tracer PET Assessment of Response to Novel Targeted Chemotherapy

PI

John M. Hoffman, MD (Morton Co-PI)

 

Source: 

National Cancer Institute (NCI)

Number

2R01CA135556-05

Project Title

Multi-tracer PET Tumor Imaging

PI

Dan Kadrmas, PhD

 

Source:

National Cancer Institute (NCI)

Number

1-R21-CA128228-01

Project Title

FDG-PET/CT in the evaluation of persistent febrile neutropenia in cancer patients

PI

John M. Hoffman, MD

 

Source: 

National Institute of Biomedical Imaging and Bioengineering (NIH)

Number

5 R03 EB014454 02

Project Title

Optimized PET Reconstruction for Cancer Detection

PI

Dan J Kadrmas, PhD

Recent Funding for CQCI Faculty

Source: 

National Cancer Institute (NIH)

Number

1 R01 CA135556-01A1

Project Title

Multi-tracer PET Tumor Imaging

PI

Dan J Kadrmas, PhD

 

Source: 

National Institute of Biomedical Imaging and Bioengineering (NIH)

Number

2 R01 EB000177-05

Project Title

Dynamic MRI for Myocardial Perfusion and Viability

PI

Edward VR DiBella, PhD

 

Source: 

University of Utah Synergy Grant Program

Number

N/A

Project Title

Development of an Integrated Molecular Biomarker of Early Prediction of Therapeutic Response to Targeted Therapy in Stage IIIB/IV or Recurrent  Lung Cancer Patients using Imaging Assessments and Genomic Modeling

PI

John M. Hoffman, MD

 

Source: 

National Cancer Institute (NIH)

Number

R01 CA121003-01

Project Title

FDG PET in cancer-associated venothromboembolic disease

PI

Kathryn A. Morton, M.D.