All Labs

Basic Science population science clinical research


Angus-Hill lab

Research in the Angus-Hill Lab has broad relevance to the study of human colorectal cancer. We use mouse genetics and molecular methods to identify and characterize candidate cancer genes to provide new insights into the etiology of colorectal cancer.


Ayer Lab

The Ayer Lab focuses on how cells communicate information about their metabolic state to the nucleus to drive adaptive changes in gene expression. We are interested in how these metabolic signals coordinate with the signals that control cell growth, division, and death of normal and cancer cells.


The primary focus of research in the Beckerle Lab is examining how cells change their behavior in response to extrinsic and intrinsic signals. These studies should clarify the basic mechanisms underlying cell behavior and lead to a better understanding of cancer and other diseases.


Bernard Lab The Bernard Lab is a translational research lab committed to the discovery and clinical implementation of biomarkers for classifying, detecting, and monitoring cancer in humans.

Bhaskara Lab

In the Bhaskara Lab, we work to understand how chromatin-modifying enzymes, specifically histone deacetylases (HDACs), control genome stability. HDAC inhibitors target certain cancers, and a better understanding of HDAC function would enable development of improved cancer treatments.


Burt-Neklason Lab

The Burt-Neklason Lab is focused on studying genes and pathways involved in familial colorectal cancers syndromes.


The Cairns Lab studies how gene transcription is regulated by chromatin structure, which is often altered in cancer cells. We also study how chromatin structure and DNA methylation/demethylation poise the genome for development (germ cells), and guide developmental processes (embryos).


Chandrasekharan Lab

The goal of the Chandrasekharan Lab is to understand the regulation and functions of histone and non-histone protein modifications during gene transcription as well as in genome stability maintenance, which is often compromised in cancer cells.


Deininger Lab

The Deininger/O'Hare Lab has a long-standing interest in the biology and therapy of leukemia, cancer of white blood cells, specifically chronic myeloproliferative neoplasms (CMPN), including chronic myeloid leukemia (CML) and Philadelphia chromosome (Ph)-negative CMPN.


edgar lab thumb

The Edgar Lab researches the mechanisms that control cell growth and proliferation in the fruit fly, Drosophila melanogaster. 


The Engel Lab researches acute leukemias and lymphomas and the role of Notch signaling in these cancers. Understanding Notch protein function and regulation in normal and malignant hematopoiesis will allow us to develop new diagnostic tools and treatment strategies for leukemia and lymphoma.


evason lab

The overarching goal of the Evason Lab is to investigate mechanisms involved in liver tumorigenesis in order to develop improved therapies to treat this deadly cancer.


gertz lab thumb

The research goal of the Gertz Lab is to understand how transcription factors choose their genomic binding sites, how binding events lead to gene expression changes, and how the actions of transcription factors are altered in cancer.


Graves Lab

The Graves Lab focuses on mechanistic questions in the area of transcriptional regulation. We strive to understand the biology and biochemistry of ETS proteins which are altered in prostate cancer, sarcoma, and hematological malignancies.


Grossman Lab

The Grossman Lab aims to understand molecular mechanisms underlying the development and progression of skin cancers. Past work has focused on survivin, a recognized inhibitor of cell death, as a model paradigm to address the role of cell death in melanoma and non-melanoma skin cancer.


Holmen Lab

The Holmen Lab aims to define critical targets in cancer cells that can become the focus for therapeutic intervention. Because of the high cost of developing new therapies, it is essential that we first identify which genetic alterations can be targeted productively.


Jensen Lab

The Jensen Lab is interested in benign and malignant brain tumor angiogenesis and biology and in developing novel treatment modalities for these tumors. Our hope is to provide cutting-edge approaches to treat brain cancer and to transition these to Phase I human clinical trials.


The K.B. Jones Lab studies the underpinnings of cancer initiation--sometimes called transformation or oncogenesis--using sarcomas as model diseases and the mouse as host. At the intersection of developmental biology and cancer, we seek to develop new therapeutic strategies to improve patient survival and quality of life.


Mendoza Lab

The Mendoza Lab seeks to understand how extracellular signals impinge on cytoskeletal dynamics and how oncogenic pathway hyperactivation impacts cancer invasion.


Oliver Lab

The Oliver Lab seeks to understand mechanisms of therapeutic response and resistance in cancer to personalize therapies based on a given tumor. We integrate human genomic/sequencing data with mechanistic data from cell culture systems and biological data from mouse models of cancer.


The Rosenblatt Lab studies both cell death and cell division and the roles that the actin and microtubule cytoskeletons play in both processes. Our lab investigates if epithelial extrusion could drive cell death in order to control cell numbers, and whether this process malfunctions in cancer.


Rosenblatt Lab

The Rutter Lab studies cellular metabolic homeostasis—the concept that cells must constantly monitor their nutrient, metabolic and hormonal environments and adjust their behavior accordingly.


SARC Lab

The SARC Lab, a division of Huntsman Cancer Institute's Sarcoma Services, is a translational and basic science research laboratory specializing in the molecular genetics of sarcomas, a connective tissue cancer, and related diseases.


Schiffman Lab

The Schiffman Lab studies pediatric hereditary cancer syndromes with a special interest in genetic susceptibility to childhood cancers.


Sharma Lab

The aim of the Sharma Lab  is to identify new drug candidates for cancer chemotherapy and to develop them to the point where they can enter clinical testing (Phase 1) in humans.  We combine medicinal chemistry of small molecule compounds with novel cell and cancer biology to achieve this goal.


Snyder Lab

Research in the Snyder Lab involves determining how the loss of cellular identity and acquisition of alternative differentiation states contributes to cancer progression and alters therapeutic response.


Spike Lab

The Spike Lab is working to decipher mechanisms underlying cellular plasticity and heterogeneity in complex tissues, including those that govern individual stem cells and cancer cells in the context of integrated multicellular systems.


Stewart Lab

Research in the Stewart Lab involves identifying genes and signaling pathways that regulate cell migration during embryonic development. We translate these findings to animal models to determine if these mechanisms are “reactivated” in the spreading of cancer.


Tavtigian Lab

The Tavtigian Lab concentrates on two areas of genetic susceptibility to cancer: identification and characterization of intermediate- and high-risk susceptibility genes and analysis of unclassified variants that are observed during the clinical testing of high-risk cancer susceptibility genes.


Ullman Lab

In the Ullman Lab, we investigate how morphological rearrangements in cell form are coordinated during cell division. We also study a protein interaction that we discovered confers aggressive tumor growth and our goal is to discover more effective cancer drug targets.


VanBrocklin Lab

The VanBrocklin Lab focuses on identifying and validating novel therapeutic targets in melanoma and lung cancer.


Varley Lab

In the Varley Lab, our goals are to answer fundamental questions about how epigenetic gene regulation is disrupted in cancer cells as well as to discover pathways and biomarkers that may have a more immediate impact on breast cancer treatment.