The Graves Laboratory focuses on mechanistic questions in the area of transcriptional regulation. We use biochemical, biophysical, and molecular biology approaches to investigate how sequence-specific DNA binding transcription factors regulate gene expression. Current projects explore signaling pathways, DNA binding properties, and protein-protein interactions within the ETS family of regulatory transcription factors with a particular interest in family members associated with human cancers.
The Graves Lab is located at the University of Utah in the Department of Oncological Sciences and Huntsman Cancer Institute. Research programs in these units include cell biology, developmental biology, signal transduction, and regulation of gene expression. These programs provide a rich training environment for students and postdoctoral fellows who are interested in basic research performed within a cancer-focused research community.