graves lab banner

Publications

View results from PubMed.

Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of Ets-1.
Desjardins G, Meeker CA, Bhachech N, Currie, SL, Graves, BJ, McIntosh LP.
Proc Natl Acad Sci USA (in press) 2014.

adobe PDF logo

Dual views of SRF: a genomic exposure.
Clark KA, Graves BJ.
Genes Dev. 2014 May 1;28(9):926-8.

adobe PDF logo

Steric mechanism of auto-inhibitory regulation of specific and non-specific DNA binding by the ETS transcriptional repressor ETV6.
De S, Chan AC, Coyne HJ 3rd, Bhachech N, Hermsdorf U, Okon M, Murphy ME, Graves BJ, McIntosh LP.
J Mol Biol. 2014 Apr 3;426(7):1390-406.

adobe PDF logo

Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain.
Coyne HJ 3rd, De S, Okon M, Green SM, Bhachech N, Graves BJ, McIntosh LP.
J Mol Biol. 2012 Aug 3;421(1):67-84.

adobe PDF logo

Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1.
Ramirez K, Chandler KJ, Spaulding C, Zandi S, Sigvardsson M, Graves BJ, Kee BL.
Immunity. 2012 Jun 29;36(6):921-32.

adobe PDF logo

Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells.
Hollenhorst PC, Ferris MW, Hull MA, Chae H, Kim S, Graves BJ.
Genes Dev. 2011 Oct 15;25(20):2147-57.

Genomic and biochemical insights into the specificity of ETS transcription factors.
Hollenhorst PC, McIntosh LP, Graves BJ.
Annu Rev Biochem. 2011;80:437-71. Review.

adobe PDF logo

The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells.
Hollenhorst PC, Paul L, Ferris MW, Graves BJ.
Genes Cancer. 2011 Jan 1;1(10):1044-1052.

adobe PDF logo

ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans.
Thyagarajan B, Blaszczak AG, Chandler KJ, Watts JL, Johnson WE, Graves BJ.
PLoS Genet. 2010 Sep 16;6(9):e1001125.

adobe PDF logo

DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association.
Green SM, Coyne HJ 3rd, McIntosh LP, Graves BJ.
J Biol Chem. 2010 Jun 11;285(24):18496-504.

adobe PDF logo

Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.
Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ.
Proc Natl Acad Sci USA. 2010 Jun 1;107(22):10026-31.

adobe PDF logo

Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors.
Oler AJ, Alla RK, Roberts DN, Wong A, Hollenhorst PC, Chandler KJ, Cassiday PA, Nelson CA, Hagedorn CH, Graves BJ, Cairns BR.
Nat Struct Mol Biol. 2010 May;17(5):620-8.

adobe PDF logo

The GNUMAP algorithm: unbiased probabilistic mapping of oligonucleotides from next-generation sequencing.
Clement NL, Snell Q, Clement MJ, Hollenhorst PC, Purwar J, Graves BJ, Cairns BR, Johnson WE.
Bioinformatics. 2010 Jan 1;26(1):38-45.

adobe PDF logo

DNA specificity determinants associate with distinct transcription factor functions.
Hollenhorst PC, Chandler KJ, Poulsen RL, Johnson WE, Speck NA, Graves BJ.
PLoS Genet. 2009 Dec;5(12):e1000778.

adobe PDF logo

Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family.
Hollenhorst PC, Shah AA, Hopkins C, Graves BJ.
Genes Dev. 2007 Aug 1;21(15):1882-94.

adobe PDF logo

Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region.
Pufall MA, Lee GM, Nelson ML, Kang HS, Velyvis A, Kay LE, McIntosh LP, Graves BJ.
Science. 2005 Jul 1;309(5731):142-5.

adobe PDF logo

The structural and dynamic basis of Ets-1 DNA binding autoinhibition.
Lee GM, Donaldson LW, Pufall MA, Kang HS, Pot I, Graves BJ, McIntosh LP.
J Biol Chem. 2005 Feb 25;280(8):7088-99.

adobe PDF logo

Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.
Foulds CE, Nelson ML, Blaszczak AG, Graves BJ.
Mol Cell Biol. 2004 Dec;24(24):10954-64.

adobe PDF logo

Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors.
Hollenhorst PC, Jones DA, Graves BJ.
Nucleic Acids Res. 2004 Oct 21;32(18):5693-702.

adobe PDF logo

Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships.
Garvie CW, Pufall MA, Graves BJ, Wolberger C.
J Biol Chem. 2002 Nov 22;277(47):45529-36.

adobe PDF logo

Autoinhibitory domains: modular effectors of cellular regulation.
Pufall MA, Graves BJ.
Annu Rev Cell Dev Biol. 2002;18:421-62. Review.

adobe PDF logo

An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors.
Seidel JJ, Graves BJ.
Genes Dev. 2002 Jan 1;16(1):127-37.

adobe PDF logo

Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition.
Cowley DO, Graves BJ.
Genes Dev. 2000 Feb 1;14(3):366-76.

adobe PDF logo

Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1).
Gu TL, Goetz TL, Graves BJ, Speck NA.
Mol Cell Biol. 2000 Jan;20(1):91-103.

adobe PDF logo

Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.
Goetz TL, Gu TL, Speck NA, Graves BJ.
Mol Cell Biol. 2000 Jan;20(1):81-90.

adobe PDF logo

Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site.
Slupsky CM, Gentile LN, Donaldson LW, Mackereth CD, Seidel JJ, Graves BJ, McIntosh LP.
Proc Natl Acad Sci USA. 1998 Oct 13;95(21):12129-34.

Specificity within the ets family of transcription factors.
Graves BJ, Petersen JM.
Adv Cancer Res. 1998;75:1-55. Review.

adobe PDF logo

Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helix.
Petersen JM, Skalicky JJ, Donaldson LW, McIntosh LP, Alber T, Graves BJ.
Science. 1995 Sep 29;269(5232):1866-9.

adobe PDF logo

Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif.
Nye JA, Petersen JM, Gunther CV, Jonsen MD, Graves BJ.
Genes Dev. 1992 Jun;6(6):975-90.

adobe PDF logo

Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus.
Gunther CV, Nye JA, Bryner RS, Graves BJ.
Genes Dev. 1990 Apr;4(4):667-79.

These publications can be downloaded for personal use and are not intended for redistribution.