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Publications

Selected Publications from the Grossman Lab:

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Aspirin and other NSAIDs as chemoprevention agents in melanoma.
Goodman J, Grossman D.
Cancer Prev Res (Phila). 2014 Apr 2.

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Survivin promotion of melanoma metastasis requires upregulation of α5 integrin.
McKenzie JA, Liu T, Jung JY, Jones BB, Ekiz HA, Welm AL, Grossman D.
Carcinogenesis. 2013 Sep;34(9):2137-44.

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Familial melanoma-associated mutations in p16 uncouple its tumor-suppressor functions.
Jenkins NC, Jung J, Liu T, Wilde M, Holmen SL, Grossman D.
J Invest Dermatol. 2013 Apr;133(4):1043-51.

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Role of melanin in melanocyte dysregulation of reactive oxygen species.
Jenkins NC, Grossman D.
Biomed Res Int. 2013;2013:908797.

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The dysplastic nevus: from historical perspective to management in the modern era: part II. Molecular aspects and clinical management.
Duffy K, Grossman D.
J Am Acad Dermatol. 2012 Jul;67(1):19.e1-12; quiz 31-2.

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The dysplastic nevus: from historical perspective to management in the modern era: part I. Historical, histologic, and clinical aspects.
Duffy K, Grossman D.
J Am Acad Dermatol. 2012 Jul;67(1):1.e1-16; quiz 17-8.

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Role of the apoptotic and mitotic regulator survivin in melanoma.
McKenzie JA, Grossman D.
Anticancer Res. 2012 Feb;32(2):397-404. Review.

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The p16(INK4A) tumor suppressor regulates cellular oxidative stress.
Jenkins NC, Liu T, Cassidy P, Leachman SA, Boucher KM, Goodson AG, Samadashwily G, Grossman D.
Oncogene. 2011 Jan 20;30(3):265-74.

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Survivin enhances motility of melanoma cells by supporting Akt activation and {alpha}5 integrin upregulation.
McKenzie JA, Liu T, Goodson AG, Grossman D.
Cancer Res. 2010 Oct 15;70(20):7927-37.

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Comparative analysis of total body and dermatoscopic photographic monitoring of nevi in similar patient populations at risk for cutaneous melanoma.
Goodson AG, Florell SR, Hyde M, Bowen GM, Grossman D.
Dermatol Surg. 2010 Jul;36(7):1087-98.

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Low rates of clinical recurrence after biopsy of benign to moderately dysplastic melanocytic nevi.
Goodson AG, Florell SR, Boucher KM, Grossman D.
J Am Acad Dermatol. 2010 Apr;62(4):591-6.

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Use of oral N-acetylcysteine for protection of melanocytic nevi against UV-induced oxidative stress: towards a novel paradigm for melanoma chemoprevention.
Goodson AG, Cotter MA, Cassidy P, Wade M, Florell SR, Liu T, Boucher KM, Grossman D.
Clin Cancer Res. 2009 Dec 1;15(23):7434-40.

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Strategies for early melanoma detection: Approaches to the patient with nevi.
Goodson AG, Grossman D.
J Am Acad Dermatol. 2009 May;60(5):719-35; quiz 736-8. Review.

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Survivin repression by p53, Rb and E2F2 in normal human melanocytes.
Raj D, Liu T, Samadashwily G, Li F, Grossman D.
Carcinogenesis. 2008 Jan;29(1):194-201.

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N-acetylcysteine protects melanocytes against oxidative stress/damage and delays onset of ultraviolet-induced melanoma in mice.
Cotter MA, Thomas J, Cassidy P, Robinette K, Jenkins N, Florell SR, Leachman S, Samlowski WE, Grossman D.
Clin Cancer Res. 2007 Oct 1;13(19):5952-8.

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Digital dermoscopic monitoring of atypical nevi in patients at risk for melanoma.
Fuller SR, Bowen GM, Tanner B, Florell SR, Grossman D.
Dermatol Surg. 2007 Oct;33(10):1198-206; discussion 1205-6.

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Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in vivo.
Cotter MA, Florell SR, Leachman SA, Grossman D.
J Invest Dermatol. 2007 Oct;127(10):2469-71.

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Predominant formation of heavily pigmented dermal melanocytomas resembling 'animal-type' melanomas in hepatocyte growth factor (C57BL/6 x C3H)F1 mice following neonatal UV irradiation.
Florell SR, Thomas J, Grossman D.
J Cutan Pathol. 2007 Sep;34(9):667-74.

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Melanocyte expression of survivin promotes development and metastasis of UV-induced melanoma in HGF-transgenic mice.
Thomas J, Liu T, Cotter MA, Florell SR, Robinette K, Hanks AN, Grossman D.
Cancer Res. 2007 Jun 1;67(11):5172-8.

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Induction of melanoma cell apoptosis and inhibition of tumor growth using a cell-permeable Survivin antagonist.
Yan H*, Thomas J*, Liu T, Raj D, London N, Tandeski T, Leachman SA, Lee RM, Grossman D.
Oncogene. 2006 Nov 2;25(52):6968-74. *Equal contribution

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Activation of dual apoptotic pathways in human melanocytes and protection by survivin.
Liu T, Biddle D, Hanks AN, Brouha B, Yan H, Lee RM, Leachman SA, Grossman D.
J Invest Dermatol. 2006 Oct;126(10):2247-56.

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Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase.
Yan H*, Brouha B*, Liu T, Raj D, Biddle D, Lee R, Grossman D.
J Dermatol Sci. 2006 Sep;43(3):189-200. *Equal contribution

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Keratinocyte apoptosis in epidermal development and disease.
Raj D, Brash DE, Grossman D.
J Invest Dermatol. 2006 Feb;126(2):243-57. Review.

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UVB-induced apoptosis drives clonal expansion during skin tumor development.
Zhang W*, Hanks AN*, Boucher K, Florell SR, Allen SM, Alexander A, Brash DE, Grossman D.
Carcinogenesis. 2005 Jan;26(1):249-57. *Equal contribution

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Proliferation, apoptosis, and survivin expression in a spectrum of melanocytic nevi.
Florell SR, Bowen AR, Hanks AN, Murphy KJ, Grossman D.
J Cutan Pathol. 2005 Jan;32(1):45-9.

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Proliferation, apoptosis, and survivin expression in keratinocytic neoplasms and hyperplasias.
Bowen AR, Hanks AN, Murphy KJ, Florell SR, Grossman D.
Am J Dermatopathol. 2004 Jun;26(3):177-81.

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Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells.
Liu T, Brouha B, Grossman D.
Oncogene. 2004 Jan 8;23(1):39-48.

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Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression.
Allen SM, Florell SR, Hanks AN, Alexander A, Diedrich MJ, Altieri DC, Grossman D.
Cancer Res. 2003 Feb 1;63(3):567-72.

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Apoptosis regulators and responses in human melanocytic and keratinocytic cells.
Bowen AR, Hanks AN, Allen SM, Alexander A, Diedrich MJ, Grossman D.
J Invest Dermatol. 2003 Jan;120(1):48-55.

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Amifostine aminothiols and protection of keratinocyte apoptosis and DNA damage.
Diedrich MJ, Warters RL, Grossman D.
J Invest Dermatol. 2002 Sep;119(3):707-8.

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Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.
Grossman D, Kim PJ, Blanc-Brude OP, Brash DE, Tognin S, Marchisio PC, Altieri DC.
J Clin Invest. 2001 Oct;108(7):991-9.

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Inhibition of melanoma tumor growth in vivo by survivin targeting.
Grossman D, Kim PJ, Schechner JS, Altieri DC.
Proc Natl Acad Sci USA. 2001 Jan 16;98(2):635-40.
PMID:

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Drug resistance in melanoma: mechanisms, apoptosis, and new potential therapeutic targets.
Grossman D, Altieri DC.
Cancer Metastasis Rev. 2001;20(1-2):3-11. Review.

These publications can be downloaded for personal use and are not intended for redistribution.