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Publications

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Preoperative dynamic contrast-enhanced MRI correlates with molecular markers of hypoxia and vascularity in specific areas of intratumoral microenvironment and is predictive of patient outcome.
Jensen RL, Mumert ML, Gillespie DL, Kinney AY, Schabel MC, Salzman KL.
Neuro Oncol. 2014 Jan;16(2):280-91.

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Experimental validation of 5 in-silico predicted glioma biomarkers.
Towner RA, Jensen RL, Vaillant B, Colman H, Saunders D, Giles CB, Wren JD.
Neuro Oncol. 2013 Dec;15(12):1625-34.

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Differential scanning calorimetry of gliomas: a new tool in brain cancer diagnostics?
Chagovetz AA, Quinn C, Damarse N, Hansen LD, Chagovetz AM, Jensen RL.
Neurosurgery. 2013 Aug;73(2):289-95.

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Treatment-related brain tumor imaging changes: So-called "pseudoprogression" vs. tumor progression: Review and future research opportunities.
Tran DK, Jensen RL.
Surg Neurol Int. 2013 Apr 17;4(Suppl 3):S129-35.

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Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007.
Towner RA, Gillespie DL, Schwager A, Saunders DG, Smith N, Njoku CE, Krysiak RS 3rd, Larabee C, Iqbal H, Floyd RA, Bourne DW, Abdullah O, Hsu EW, Jensen RL.
Neuro Oncol. 2013 Mar;15(3):330-40.

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ELTD1, a potential new biomarker for gliomas.
Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F, Giles CB, Wren JD.
Neurosurgery. 2013 Jan;72(1):77-91.

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Hypoxia-inducible factor-1-regulated protein expression and oligodendroglioma patient outcome: comparison with established biomarkers and preoperative UCSF low-grade scoring system.
Abraham S, Hu N, Jensen R.
J Neurooncol. 2012 Jul;108(3):459-68.

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Predicting outcomes of patients with intracranial meningiomas using molecular markers of hypoxia, vascularity, and proliferation.
Jensen R, Lee J.
Neurosurgery. 2012 Jul;71(1):146-56.

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In vivo characterization of several rodent glioma models by 1H MRS.
Doblas S, He T, Saunders D, Hoyle J, Smith N, Pye Q, Lerner M, Jensen RL, Towner RA.
NMR Biomed. 2012 Apr;25(4):685-94.

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Preliminary use of differential scanning calorimetry of cerebrospinal fluid for the diagnosis of glioblastoma multiforme.
Chagovetz AA, Jensen RL, Recht L, Glantz M, Chagovetz AM.
J Neurooncol. 2011 Dec;105(3):499-506.

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Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1alpha.
Chintala S, Tóth K, Cao S, Durrani FA, Vaughan MM, Jensen RL, Rustum YM.
Cancer Chemother Pharmacol. 2010 Oct;66(5):899-911.

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Direct DNA methylation profiling using methyl binding domain proteins.
Yu Y, Blair S, Gillespie D, Jensen R, Myszka D, Badran AH, Ghosh I, Chagovetz A.
Anal Chem. 2010 Jun 15;82(12):5012-9.

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Multiinstitutional validation of the University of California at San Francisco Low-Grade Glioma Prognostic Scoring System. Clinical article.
Chang EF, Clark A, Jensen RL, Bernstein M, Guha A, Carrabba G, Mukhopadhyay D, Kim W, Liau LM, Chang SM, Smith JS, Berger MS, McDermott MW.
J Neurosurg. 2009 Aug;111(2):203-10.

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Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target.
Jensen RL.
J Neurooncol. 2009 May;92(3):317-35. Review.

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Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice.
Wang XL, Xu R, Wu X, Gillespie D, Jensen R, Lu ZR.
Mol Pharm. 2009 May-Jun;6(3):738-46.

Silencing of HIF-1alpha by RNA interference in human glioma cells in vitro and in vivo.
Gillespie DL, Flynn JR, Ragel BT, Arce-Larreta M, Kelly DA, Tripp SR, Jensen RL.
Methods Mol Biol. 2009;487:283-301.

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Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme.
Flynn JR, Wang L, Gillespie DL, Stoddard GJ, Reid JK, Owens J, Ellsworth GB, Salzman KL, Kinney AY, Jensen RL.
Cancer. 2008 Sep 1;113(5):1032-42.

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A comparison of the cell lines used in meningioma research.
Ragel BT, Couldwell WT, Gillespie DL, Wendland MM, Whang K, Jensen RL.
Surg Neurol. 2008 Sep;70(3):295-307.

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A novel model of intracranial meningioma in mice using luciferase-expressing meningioma cells. Laboratory investigation.
Ragel BT, Elam IL, Gillespie DL, Flynn JR, Kelly DA, Mabey D, Feng H, Couldwell WT, Jensen RL.
J Neurosurg. 2008 Feb;108(2):304-10.

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A multifunctional and reversibly polymerizable carrier for efficient siRNA delivery.
Wang XL, Nguyen T, Gillespie D, Jensen R, Lu ZR.
Biomaterials. 2008 Jan;29(1):15-22.

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A novel environment-sensitive biodegradable polydisulfide with protonatable pendants for nucleic acid delivery.
Wang XL, Jensen R, Lu ZR.
J Control Release. 2007 Jul 31;120(3):250-8.

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Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis.
Ragel BT, Couldwell WT, Gillespie DL, Jensen RL.
Neurosurg Rev. 2007 Jul;30(3):181-7.

Peritumoral edema after stereotactic radiosurgery for intracranial meningiomas and molecular factors that predict its development.
Kan P, Liu JK, Wendland MM, Shrieve D, Jensen RL.
J Neurooncol. 2007 May;83(1):33-8.

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Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo.
Gillespie DL, Whang K, Ragel BT, Flynn JR, Kelly DA, Jensen RL.
Clin Cancer Res. 2007 Apr 15;13(8):2441-8. Erratum in: Clin Cancer Res. 2008 Jan 1;14(1):326.

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Celecoxib inhibits meningioma tumor growth in a mouse xenograft model.
Ragel BT, Jensen RL, Gillespie DL, Prescott SM, Couldwell WT.
Cancer. 2007 Feb 1;109(3):588-97.

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Calcium channel antagonists augment hydroxyurea- and ru486-induced inhibition of meningioma growth in vivo and in vitro.
Ragel BT, Gillespie DL, Kushnir V, Polevaya N, Kelly D, Jensen RL.
Neurosurgery. 2006 Nov;59(5):1109-21.

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Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms.
Rong Y, Hu F, Huang R, Mackman N, Horowitz JM, Jensen RL, Durden DL, Van Meir EG, Brat DJ.
Cancer Res. 2006 Jul 15;66(14):7067-74.

Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas.
Jensen RL, Ragel BT, Whang K, Gillespie D.
J Neurooncol. 2006 Jul;78(3):233-47.

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Hypoxia in the tumorigenesis of gliomas and as a potential target for therapeutic measures.
Jensen RL.
Neurosurg Focus. 2006 Apr 15;20(4):E24. Review.

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Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factors.
Layfield LJ, Willmore C, Tripp S, Jones C, Jensen RL.
Appl Immunohistochem Mol Morphol. 2006 Mar;14(1):91-6.

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Ubiquitous expression of cyclooxygenase-2 in meningiomas and decrease in cell growth following in vitro treatment with the inhibitor celecoxib: potential therapeutic application.
Ragel BT, Jensen RL, Gillespie DL, Prescott SM, Couldwell WT.
J Neurosurg. 2005 Sep;103(3):508-17.

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Endolymphatic sac tumors in patients with and without von Hippel-Lindau disease: the role of genetic mutation, von Hippel-Lindau protein, and hypoxia inducible factor-1alpha expression.
Jensen RL, Gillespie D, House P, Layfield L, Shelton C.
J Neurosurg. 2004 Mar;100(3):488-97.

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Expression of hypoxia inducible factor-1 alpha and correlation with preoperative embolization of meningiomas.
Jensen RL, Soleau S, Bhayani MK, Christiansen D.
J Neurosurg. 2002 Sep;97(3):658-67.

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Calcium channel antagonists inhibit growth of subcutaneous xenograft meningiomas in nude mice.
Jensen RL, Wurster RD.
Surg Neurol. 2001 May;55(5):275-83.

Calcium channel antagonist effect on in vitro meningioma signal transduction pathways after growth factor stimulation.
Jensen RL, Petr M, Wurster RD.
Neurosurgery. 2000 Mar;46(3):692-703.

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Growth factor-mediated angiogenesis in the malignant progression of glial tumors: a review.
Jensen RL.
Surg Neurol. 1998 Feb;49(2):189-96. Review.

Matrigel augments xenograft transplantation of meningioma cells into athymic mice.
Jensen RL, Leppla D, Rokosz N, Wurster RD.
Neurosurgery. 1998 Jan;42(1):130-6.

Inhibition of in vitro meningioma proliferation after growth factor stimulation by calcium channel antagonists: Part II--Additional growth factors, growth factor receptor immunohistochemistry, and intracellular calcium measurements.
Jensen RL, Lee YS, Guijrati M, Origitano TC, Wurster RD, Reichman OH.
Neurosurgery. 1995 Nov;37(5):937-47.

In vitro growth inhibition of growth factor-stimulated meningioma cells by calcium channel antagonists.
Jensen RL, Origitano TC, Lee YS, Weber M, Wurster RD.
Neurosurgery. 1995 Feb;36(2):365-74.

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