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Our Research

The Cannon-Albright lab is active in many disease areas, with a major focus on cancer. We have two major areas of concentration. The first area is the creation and analysis of large genealogical databases to explore the genetics of health-related phenotypes.  We are currently funded by the VHA to build a U.S. genealogy and link to the VHA patient database of 25 million. The second area is the study of high-risk pedigrees to identify disease predisposition genes or variants.

We ascertain and recruit high-risk pedigrees identified in the Utah Population Database, or UPDB, which combines computerized genealogies of Utah with statewide medical data (e.g. Utah Cancer Registry from 1966, Utah Death Certificates from 1904, UUHSC diagnosis and procedure coding from 1994). We are active in gene identification efforts for prostate cancer, colon cancer, melanoma, Ewing sarcoma, pancreas cancer, and lung cancer.  We have stored over 35,000 DNAs from informative members of thousands of high-risk pedigrees for many phenotypes. The entire lab is funded almost exclusively by external funding agencies including NIH, NCI, VHA, AACR, and Alex’s Lemonade Stand.