The post-genomic era holds many promises for addressing fundamental questions about biology and improving patient outcome through personalized medicine. As a molecular and computational scientist I make use of microarray and next generation sequencing (NGS) technologies to address these exciting challenges. This involves forming collaborations with biostatisticians to create award winning NGS software tools (ChIP/RNA/Bis-Seq: http://useq.sourceforge.net), working closely with researchers to answer fundamental questions about chromatin and transcriptional regulatory networks (Hammoud et.al, Dutrow et. al, ENCODE), and leading a team of computer scientists to develop software applications critical to the effective use of NGS technology in the laboratory and clinic. These include the first open source Genomic LIMS and Analysis Project Center (GNomEx: http://gnomex.sourceforge.net) and an archetype genomic data annotation and distribution server (GenoPub: http://bioserver.hci.utah.ed/BioInfo/index.php/Software:DAS2) that we recently published. As a research assistant professor in Oncological Sciences and co-director of the University of Utah’s Bioinformatics Shared Resource, I embrace this work whole-heartedly, with passion and dedication. It is an honor to be able to participate in these “game changing” endeavors.