biorepository and molecular pathology core banner
slider

Services

  • Project Registration
    This required registration reserves biospecimens for specific projects as defined by the investigator or disease group.  The Biorepository manages these registrations using the itBioPath tracking system.  

 

  • HCI Centralized Protocol
    Investigators may use the centralized protocol, Molecular Classifications of Cancer (IRB# 10924), to procure, process and store biospecimens for cancer research.

 

  • Project Coordination
    Research team meetings and training sessions are provided to define the key procurement activities for each staff member involved in the process.

 

  • Informed Patient Consent
    The Biorepository coordinators provide consent training to the clinic and surgery staff.  They are also available to assist consenting patients as needed.  Written informed consent from each donor is in accordance with the Department of Health and Human Services (HHS) regulations. 

 

  • Consent Management
    Consents are validated, uploaded and linked to the biospecimen collection events using the itBioPath tracking system while following HIPAA regulations and maintaining protected health information.

 

  • Blood and Body Fluid Procurement, Processing and Storage
    Project specific blood collection kits are prepared and stocked in the clinic and surgery areas.  Blood and body fluids are procured, de-identified, processed, stored and assigned to a registered project using the itBioPath tracking system.

 

  • Tissue Procurement, Processing and Storage
    Tissue collection kits are prepared prior to the surgical event.  Tissues are transported from the operating rooms to Pathology where surplus tissue is verified for research after the clinical diagnosis.  The tissues are then de-identified, processed, stored and assigned to a registered project using the itBioPath tracking system. 

 

  • Biospecimen Distribution
    Blood, body fluids, tissues and their derivatives stored in the Biorepository are available upon request.  Tissues distributed for research are confirmed by the Biorepository or collaborating pathologist prior to release.  Permissions to release specimens may require investigator or group approval. 

 

  • itBioPath Tracking System
    This robust system developed by the HCI Research Informatics shared resource is used by the Biorepository to track all biospecimen activities from the patient consent to distribution.  Patient information is de-identified and specimens are annotated and tracked in the itBioPath (Integrative Transdisciplinary Biospecimen and Pathology Annotation Translational Health) system enabling associated links to important clinical and pathological information. 

The itBioPath tracking system links to the following clinical and research databases:

-Enterprise Data Warehouse (clinical records link; pathology, medicine and radiology)

-Oncolog and Tumor Registry (cancer stage, outcomes, vital statistics)

-Cancer Clinical Research-CCR (Subject Registry, cohort Studies, medical events, clinical pathology)

-Utah Population Database (genealogy, birth and death certificates)

-Genomix (molecular data)

 

  • Quality Management
    The Biorepository accreditation from the College of American Pathologists (CAP) ensures quality biospecimens by implementing and monitoring best practices thus improving research outcomes.
BIOSPECIMEN PREP/TYPES
Blood (whole) Nails
Blood Panel (Whole Blood + PL1 + BUF) Paxgene RNA
Buccal Cells Plasma, Single Spin
Buffy Coat, Unficolled Viable Plasma, Double Spin
Cerebrospinal Fluid RNA
Consent Management Saliva, Oragene
Consent Patient Serum
Disbursement Stool
DNA Tissue, All
Mononuclear Cells (MNC) -CPT/Ficoll, Viable Urine
STORAGE/TRANSPORT PREPS TEMPERATURE RANGES
(Ambient, 40C, -200C, -800C, -1350C)
Freeze RNAlater®
Cryopreserve, DMSO or Glycerol RNAprotect Cell Reagent
Formalin, 10% NBF to Histology (FFPE) RPMI
ICE Shipping
OCT Specimen Acquisition