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Patient-Derived Xenograft Repository

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Patient derived xenografts, or PDX, are samples grafted directly from a patient into an immunodeficient mouse. Under these conditions, the tumor continues to grow and metastasize, allowing propagation of the human cancer.

At the PRR, we have a tissue bank of 15 breast cancers, with all common subtypes represented. Publications have shown that the breast PDX models maintain similar molecular profiles to the parent tumor meaning these tumorgrafts create an excellent model to test new chemotherapies and drug delivery systems in a preclinical setting.

We can help you use these tumor models to test your small molecule, including implantation of tumor tissue, tumor growth monitoring, drug dosing, and necropsy.

See the full list of available breast PDX models, including subtype and receptor status here.

In addition to the characterized breast PDX model, we work closely with the BMP to collect and transplant other cancer types, including melanoma. If there is a specific cancer you would like collected, we can work to facilitate your requests.