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Mass Spectrometry and Proteomics

Director
Chad Nelson, PhD
chad.nelson@genetics.utah.edu
801-585-9865

The Mass Spectrometry and Proteomics (MSP) Shared Resource provides Huntsman Cancer Institute (HCI) members and the entire University of Utah research community a broad range of mass spectrometry services, including state-of-the-art instrumentation, consultation, and expertise, particularly for proteomics-based research. The hybrid Fourier-Transform mass spectrometer (model LTQ-FT, ThermoElectron) is the main proteomics instrument. It provides protein identification (ID) at levels as low as 50 attomole, high-mass accuracy (2ppm), and peptide sequencing by electron-capture dissociation (ECD), infrared multiphoton dissociation (IRMPD), and collision-induced dissociation (CID). Proteomics services include protein ID; characterization of post-translational modifications (e.g., phosphorylation); and analysis of intact proteins. The Resource also provides mass spectrometry services for a wide range of other research applications such as structural analysis of natural products, drugs and drug-polymer conjugates, nucleic acids, DNA amplification products (e.g., PCR), large biomolecules and polymers, peptides, and small synthetic molecules. The instrumentation and staff of the MSP Shared Resource are centrally located.

The MSP Shared Resource serves all HCI laboratory-based scientific Programs (Nuclear Control of Cell Growth and Differentiation, Cell Response and Regulation, and Experimental Therapeutics), characterizing molecules, particularly proteins and post-translational modifications, that play roles in cancer mechanisms. In addition, characterization of small compounds by the MSP Shared Resource, including natural products and drug-delivery polymers, contributes significantly to the developmental therapeutics activities of HCI.

For more information, please see the Mass Spectrometry and Proteomics webpage on the University of Utah HSC Core Facility website: http://www.cores.utah.edu/maincores/main-core-facilities/massspec.

Mass Spectrometry and Proteomics Governance

Director
Chad Nelson, PhD

HCI Senior Director Oversight
Bradley Cairns, PhD

Faculty Advisory Committee Members
Bradley Cairns, PhD
Darrell Davis, PhD
Annette Fleckenstein, PhD
Guy Zimmerman, MD

If use of this resource results in a publication, please acknowledge the Cancer Center Support Grant by using the following text: "The project described was supported by Award Number P30CA042014 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health."