Beta Blocker Effect on Remodeling and Gene Expression (BORG)
Study Description
This study examines changes myocardial gene expression associated with related alterations in myocardial function and remodeling, and specifically with carvedilol, metoprolol or metoprolol plus doxazosin-related reversal of myocardial dysfunction and remodeling.
Contact Information
Status:
Name, Phone, Email:
Kirk Volkman, NP
Jerri Housley, Research Coordinator
801-585-5122
Kirk.volkman@hsc.utah.edu
Jerri.housley@hsc.utah.edu
Principle Investigator:
Edward Michael Gilbert, M.D.
Please Note:
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Although the studies described on this Web site may have potential benefits as described, the University of Utah and its physicians and affiliated hospitals cannot and do not guarantee or promise that you will receive any benefits from participating in a study.
Participant Eligibility
Inclusion Criteria:- Age Range: > 18 years
- Patients with idiopathic dilated cardiomyopathy must have symptoms of New York Heart Association (NYHA) Class II, III or IV congestive heart failure (CHF) at the time of randomization. Left ventricular diastolic diameter index (LVIDd) should be greater than 3.0 cm/m as measured by two-dimensional echocardiography (2-D Echo). Patients must have a coronary arteriogram performed within at least two years of enrollment that does not exhibit occlusive (> 50 % narrowing of any major epicardial coronary artery) and be free of a clinical history consistent with coronary artery disease (CAD)
Patients currently treated with carvedilol > 3.125 mg bid.
How long does the study run?
Until 14 patients are enrolledLocation(s) of the Clinical Trial
University of Utah Health Sciences Outpatient Clinic #10
