The Spectrum of Iron Overload in End-stage Liver Disease and Its Impact Upon Transplant Morbidity and Mortality
This study seeks to identify patients that may be at risk for iron overload, both pre and post transplantation; as well as clarify the etiology, and examine the prevalence of post transplant morbidity in these patients.
The following objectives are being examined:
- The prevalence and spectrum of iron overload in patients with ESLD and its post-transplant impact on morbidity and mortality.
- Pre- and post-transplant cardiac pathophysiology and morbidity.
- Pre-and post-transplant infectious morbidity.
- Pre-and post-transplant metabolic pathophysiology and morbidity.
- Recurrent and de novo malignancies post-transplant.
- All consecutive patients with end-stage liver disease (ESLD) presenting as candidates for liver transplant with cirrhosis, will be offered the opportunity to participate in this study. Patients must be over 18 years of age.
Guidelines for Ineligibility:
- Patients under 18 years of age.
- Patients undergoing liver transplants without cirrhosis (eg; Fulminant liver failure, malignancies in non-cirrhotics and re-transplantations).
- Patients undergoing a re-transplantation.
- Mentally handicapped individuals.
- Patients that are incarcerated.
- Pregnant females.
How long does it run?
Approximately 120 patients will be enrolled over the next ten years
Location(s) of clinical trial
University of Utah Hospital
Salt Lake City, Utah, United States, 84105
Principal Investigator: Tim Gayowski, M.D.
Status: Open Enrollment
Name, Phone, Email
Contact: Tim Gayowski, M.D. 801-585-3740
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