Naproxen on Heterotopic Bone following Hip athroscopy

Principal Investigator: Stephen Aoki
Keywords: Naproxen , Hip Arthroplasty , Bone formation Department: Orthopedic Surgery
IRB Number: 00048961 Co Investigator:  
Specialty: Orthopaedic Surgery
Sub Specialties: Hip Arthroscopy
Recruitment Status: Enrolling by invitation

Contact Information

Deveree Partridge

Brief Summary

Primary Objective
1. The primary objective of this investigation is to evaluate the effectiveness of Naproxen in preventing radiographically detected heterotopic ossification following hip arthroscopy for the treatment of femoroacetabular impingment

Secondary Objectives
2. Document potential complications associated with NSAID therapy in the postoperative period including GI upset, GI bleed, femoral neck fractures
3. Classify the extent of HO when present following hip arthroscopy
4. Investigate functional clinical outcomes such as hip range of motion, pain, and need for repeat surgery of heterotopic bone formation following hip arthroscopy

Detailed Description

Heterotopic bone formation (HO) is a potentially serious complication of hip surgery. HO, defined as the formation of normal bone in an abnormal soft tissue location, results from alteration in the normal regulation of skeletogenesis. Although most patients remain asymptomatic despite HO development , two articles that included 10,826 patients from 37 studies suggest HO may be associated with substantial compromise of function and range of motion even at low grades [Vavken 10, 22]. In a large pooled incidence study, HO was estimated to be 43% in 59,121 patients undergoing total hip arthroplasty, and 51% in 998 patients after acetabular trauma [Neal, Brue]. Few studies have reported on the incidence of HO following hip arthroscopy. However, HO is an increasingly reported complication of arthroscopic treatment for femoroacetabular impingement (FAI). In a comparison of complications following arthroscopic treatment of FAI in 8 case-series, ectopic ossification occurred in up to 6% of cases and accounted for 10 of the 19 reported complications [Gedouin]. Additionally, one recent study reported an HO incidence of 33% following hip arthroscopy in patients not prophylaxed with NSAID therapy. In our experience, HO occurs at a comparable or higher rate of 10% in those undergoing this procedure. The formation of ectopic ossification is triggered as a result of muscle damage during introduction of hip portals and is potentially augmented by seeding of bone shavings in the soft tissues created during burring of the femoral neck. Prophylaxis of HO targets the biochemical mechanisms of heterotopic bone formation by: 1) Disrupting inductive signaling pathways, 2) Altering osteoprogenitor cells in target tissues, and 3) Modifying the environment conductive to formation of heteroptic bone. The two mainstays of therapy are low dose radiation treatment and non-steroidal anti-inflammatory medications (NSAIDs). The efficacies of these treatments were found to be equivalent by Burd et al in 166 randomized patients [Burd]. However, NSAID therapy was shown to be considerably more cost effective with lower rates of morbidity. Large randomized studies have subsequently shown large reductions in the incidence of HO using NSAID therapy in the perioperative period. The Cochrane review of 16 randomized trials in 5000 patients found one-half to two-thirds reduction in HO with indomethacin. Even less potent NSAID therapy has been effective in reducing rates of HO. Fransen et al reported a 30% reduction in HO during the HIPAID trial comparing perioperative ibuprofen with placebo in nearly 1000 patients. We hypothesize that NSAID prophylaxis of HO may have a role in hip arthroscopy for the treatment of femoroacetabular impingement. All NSAIDs tested, with the exception of aspirin, have resulted in significant decreases in the incidence of HO following hip surgery including less potent regimens such as ibuprofen 1200 mg/day [Fransen]. Naprosyn offers the advantage of twice daily dosing with similar potency to ibuprofen. It is readily available and inexpensive. Furthermore, in an unpublished series of 50 patients prescribed naprosyn following hip arthroscopy for FAI, we have had no cases of HO at 6 month follow up compared to a 5-10% rate in patients who received no prophylaxis. We propose testing our hypothesis that perioperative naproxen will reduce the incidence of HO following hip arthroscopy for femoroacetabular impingement in a placebo controlled, double-blinded, randomized controlled trial.

Inclusion Criteria

1. The patient is 18-80 years of age.
2. The patient has provided written informed consent.
3. The patient is scheduled for hip arthroscopy surgery for treatment of FAI
4. The patient has an ASA of I, II, or III.
5. The patients understands the explanation of the protocol.

Exclusion Criteria

1. The patient has history of a major GI bleeding event
2. The patients has a history of renal impairment or creatinine > 1.5
3. The patient has taken NSAIDs within 48 hours of surgery or in the perioperative period
4. The patient has a history of heterotopic ossification following surgery
5. The patient has a hypersensitivity reaction to Naproxen
6. The patient is undergoing a concomitant procedure in addition to treatment of FAI